DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and chrna9

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_012811629.2	Gene:	chrna9 / 100493319	XenbaseID:	XB-GENE-983401	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	180/500 - (36%)
Similarity:	285/500 - (56%)	Gaps:	36/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDM 120
            |.|.:.:.|...|.::|::..|||.:....|.:|..:||.||.||||:||:|...:|::|.|.|.
Frog    27 AKGKYAQMLFRDLFEDYSNALRPVEDTDKALNVSLQITLSQIKDVDERNQILTAYLWIRLSWYDA 91

  Fly   121 NLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTC 185
            .|:|:..|:.|:..:|||.:.:|:||:::||.||:.|.....||||:|.:|...:..|.|.||:|
Frog    92 YLKWDRDEYDGLDSIRIPSNMVWRPDIVLYNKADDEFSEPVNTNVVLRYDGKITWDSPAITKSSC 156

  Fly   186 KIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNC 250
            .:|:::||||:|:|.:.||||||:|.|:|: :.....||:|.|:.|.||::.|:|..:|.|.|.|
Frog   157 VVDVSYFPFDNQQCNLTFGSWTYNGNQVDI-INTMDSGDLSDFVENVEWEMQGMPAVKNVITYGC 220

  Fly   251 CPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLN 315
            |.|||.||||.::::|::.:|.|||::|||:|:.:|.|||.||.|||||:|||||:||:||||..
Frog   221 CSEPYPDITFTLILKRRSSFYIFNLLIPCVMISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQL 285

  Fly   316 MVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCI 380
            ||||:|| .|::|||:|.|:...|.|:.:|...||:|:|.|...|:...:..|.|::.|.::..|
Frog   286 MVAESMP-PSESVPLIGKYYIATMTMITASTALTIIIMNIHLCGPEAKPIPRWARIVILDYMSKI 349

  Fly   381 LRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASA 445
            ..:.   .||..|..|.|.|.:.::| .....::.| ||:...|.|...|....:|.|:......
Frog   350 FFVY---DVGENCTSPQSDSDTKSNG-SVPSYEDYE-KEQEPYSSLGCPLSGSGNFSCDIDTNKK 409

  Fly   446 TLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHT-CLTSSAEYELALILKELRWITE 509
            ...|...:|                        .|.:.||.| |......|.  ::...:.:||.
Frog   410 LNGHLGGHY------------------------ALQKEISETHCCAHCNRYR--VLTNNIEYITN 448

  Fly   510 QLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSA 554
            ..:::...|....:||..|.|:||..:.:|  |:::..:::|..|
Frog   449 WYREQKAISAKGIEWKKVAKVMDRFFMWVF--FSMVFFMSILIIA 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	176/489 (36%)
		Neur_chan_LBD	61..268	CDD:280998	87/206 (42%)
		Neur_chan_memb	275..552	CDD:280999	86/277 (31%)
chrna9	XP_012811629.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920