Protein Alignment nAChRalpha7 and chrna10

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_031753261.1
• Gene: chrna10 / 100487976
• -ID: -
• Length: 501
• Species: Xenopus tropicalis
• Alignment Length: 525
• Identity: 182/525 - (34%)
• Similarity: 293/525 - (55%)
• Gaps: 54/525 - (10%)

  Fly    49 LIMIPAC--AAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNI 111
            |.::|..  |.|....:|::.|..||::..|||.:....:.::..:||.||||:||:||:|:..:
 Frog    11 LCLLPGVQGAQGRFAYKLMNDLFANYSNALRPVEDMDKAMNVTLQVTLSQIIDMDERNQILMAYL 75

  Fly   112 WLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYV 176
            |::..|.|..||||..::.|:..:|||...:|:||:::||:||:.|.|:..||||:|.:|..::.
 Frog    76 WIRQVWFDAYLRWNKEDYDGLDTIRIPSSYVWRPDIVLYNNADDQFTGSMETNVVIRYDGQIMWD 140

  Fly   177 PPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPG 241
            .|.|.||:||:|:::||||.|:|.:.||||||:|.|:|: |.....||::.|:.|.||::||:|.
 Frog   141 SPAITKSSCKVDVSFFPFDGQQCRLTFGSWTYNGNQIDI-LNHLDTGDLTDFVENVEWEILGMPA 204

  Fly   242 KRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTI 306
            |::.|.|.||.|||.|:|:.::::|:..:|.|||::|||:|:.:|.|||.||.|||||:|||||:
 Frog   205 KKSVITYGCCSEPYPDVTYTLILKRRASFYIFNLLLPCVMISFLAPLGFYLPADSGEKVSLGVTV 269

  Fly   307 LLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRV 371
            ||:||||..:|||:|| .|:.|||:|.|:...|.|:.:|...||.|:|.||..|:...:.:|.:.
 Frog   270 LLALTVFQLLVAESMP-PSENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEAKPVPQWAKK 333

  Fly   372 IFLYWLPCILRMQRPGQVGYEC------PPPPSSSSSSASG----EKKQQIQNVELKERSSKSLL 426
            ..|.::..|..:.   :||..|      |.|.|..:|...|    .|::.|.:|
 Frog   334 FILQYMSRIFFVY---EVGESCRRPRTEPEPNSERTSKVPGIDGQAKREDIADV----------- 384

  Fly   427 ANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDG-------RLHEAI 484
              |.|..:......:.|...|.|      :.|....:.....|...|.|..|       ::|
 Frog   385 --VKDCPEKLSPKDKEAKEELEH------SKYAHSQESGKYYVSEQGGVGKGFGYEECPKIH--- 438

  Fly   485 SHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLA 549
               ||..:..     :||.:.:|....:.:..|...|.:||..|.|:||..:.:|.:...:.::.
 Frog   439 ---CLCHNER-----LLKNIEYIANCFRDQRATQKRTGEWKKVAKVMDRFFMWVFFIMVFLMSVL 495

  Fly   550 VLFSA 554
            ::..|
 Frog   496 IMGKA 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	177/505 (35%)
		Neur_chan_LBD	61..268	CDD:280998	87/206 (42%)
		Neur_chan_memb	275..552	CDD:280999	87/293 (30%)
chrna10	XP_031753261.1	LIC	27..496	CDD:273305	177/503 (35%)
		LGIC_ECD_nAChR_A10	50..230	CDD:349824	79/180 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920