Protein Alignment nAChRalpha7 and LOC100487782

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_031759268.1
• Gene: LOC100487782 / 100487782
• -ID: -
• Length: 512
• Species: Xenopus tropicalis
• Alignment Length: 513
• Identity: 246/513 - (47%)
• Similarity: 336/513 - (65%)
• Gaps: 53/513 - (10%)

  Fly    58 GPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNL 122
            |.::::|...||.|||.|||||||:|.||.:...|||:||||||||||:||||.||::.|||..|
 Frog    31 GQYQRKLYRELLRNYNRLERPVVNDSQPLLVELQLTLLQIIDVDEKNQVLITNAWLQITWNDFYL 95

  Fly   123 RWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKI 187
            .|:.:|:.||:.||.|...:|.||:|:||||||.||.|:.|||:|.:.|:|.|:||||.||||.|
 Frog    96 TWDQAEYPGVQTLRFPADHIWVPDILLYNSADERFDATFHTNVLVNSTGACQYIPPGILKSTCYI 160

  Fly   188 DITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCP 252
            |:.|||||.|:|::||||||::|:.||||:.:   .||||:|.||||||:||||||||:||.||.
 Frog   161 DVRWFPFDVQKCKLKFGSWTHNGWLLDLQMME---ADISSYIPNGEWDLVGVPGKRNELYYECCK 222

  Fly   253 EPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMV 317
            |||.|:|:.:.:||:||||..||::|||||:.:|||.|.||.|||||:|||:|:|||||||:.:|
 Frog   223 EPYPDVTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADSGEKISLGITVLLSLTVFMLLV 287

  Fly   318 AETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILR 382
            ||.||||||:|||:..||..||.:|..|||.|:|:|.:||.:|...:|.:.:|||.|.|....||
 Frog   288 AEIMPATSDSVPLIAQYFASIMVIVGLSVVVTVLVLQFHHHDPQAGKMPKMVRVILLNWCAWFLR 352

  Fly   383 MQRPGQVGYECPPP-----PSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCN-HR 441
            |::||:  .:.|.|     |:..||.:|.|     .|:....:|:.   .|::      .|. |.
 Frog   353 MRKPGE--NKRPIPCKYIYPNHHSSISSIE-----MNIAPGHQSTN---GNIV------YCGYHT 401

  Fly   442 CASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLH-------EAISHTCLTSSAEYELAL 499
            ..|...|                   |...:| |:..|::       :.|....|..|.. |:..
 Frog   402 LESPCCP-------------------PNSDSG-VMCARVNCPSLEDSDLIQKKSLKESMP-EIVK 445

  Fly   500 ILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHF 557
            ||:|:::|..:.:::|...:|..:|||||.|:|||||:.|:||.||||..:|.|||:|
 Frog   446 ILEEVQYIARRFREQDAGEEICSEWKFAAAVIDRLCLVAFSLFAIIATFTILMSAPNF 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	239/501 (48%)
		Neur_chan_LBD	61..268	CDD:280998	124/206 (60%)
		Neur_chan_memb	275..552	CDD:280999	111/289 (38%)
LOC100487782	XP_031759268.1	LIC	16..500	CDD:273305	242/508 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1510
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134707
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1318
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm9339
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010