Protein Alignment nAChRalpha7 and chrnb1

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001240739.1
• Gene: chrnb1 / 100006941
• ZFINID: ZDB-GENE-070821-4
• Length: 492
• Species: Danio rerio
• Alignment Length: 530
• Identity: 174/530 - (32%)
• Similarity: 273/530 - (51%)
• Gaps: 80/530 - (15%)

  Fly    50 IMIPACAAG--------PHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106
            |:|..|..|        ..|.:|:..|...|||..||..|..:.:.:..|:.|...:.::.|::.
Zfish     7 IIITCCLCGLGAMTGATEMEDKLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMKDEE 71

  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNG 171
            :.|.:.:.|||||..|.||..::|||..|||...::|.||:::.|:.|..|......:|...:||
Zfish    72 MNTIVMMNLEWNDYRLSWNPKDYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVHVQAYSNG 136

  Fly   172 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQ-LQDEAGGDI------SSFI 229
            ...:.||.::||:|.:.:|:||||.|.|.|.|.|:|||..::||| ..|:.|.:|      :.|.
Zfish   137 RVTWTPPALYKSSCGVKVTYFPFDWQNCTMVFRSYTYDSSEVDLQHALDKRGKEIKEIILDTGFS 201

  Fly   230 TNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPP 294
            .:|||.:.....::     |...:.|.||||.::|.||.::|..|:::||:||..:|:..|.|||
Zfish   202 ESGEWHIRHKVSRK-----NVREDLYEDITFYLIIERKPMFYVVNIVLPCILITIIAIFNFYLPP 261

  Fly   295 DSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRN 359
            |:|||:.|.:.:||:|||||.::|..:|.||..||::..|....|.:|..||:.::::||.|||:
Zfish   262 DAGEKMGLSINVLLTLTVFLLLLANKIPETSLGVPIIVNYLMITMILVTFSVILSVVVLNLHHRS 326

  Fly   360 PDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECP---PPPSSSSSSASGEKKQQIQNVE----- 416
            |:||:|..|:|.||::.||..|.|.||   ..|.|   ..|:         ||:.||.:.
Zfish   327 PNTHQMPLWVRKIFIHMLPPYLGMLRP---KVETPLFLEKPA---------KKENIQAINRVADE 379

  Fly   417 --LKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGR 479
              :::.|:.:.|         |...||       :||....|..|:              .:||.
Zfish   380 YFIRKPSNMNFL---------FPKPHR-------YQPDGQCTDLRK--------------FIDGP 414

  Fly   480 LHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTI 544
            .|      .||...|.:.|  ::.:.:|.|||:.|.:...:..||::.|||.|||.|.||.:||.
Zfish   415 SH------YLTLPPELKTA--VEAITYIAEQLQAEKDYEALKEDWQYVAMVADRLFLWIFVIFTT 471

  Fly   545 IATLAVLFSA 554
            :.||.:...|
Zfish   472 LGTLGIFTDA 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	167/505 (33%)
chrnb1	NP_001240739.1	LGIC_ECD	26..235	CDD:475126	72/213 (34%)
		Neur_chan_memb	242..478	CDD:460753	94/285 (33%)