Protein Alignment out and SLC16A4

DIOPT Version :10

• Sequence 1: NP_573378.1
• Gene: out / 32926
• FlyBaseID: FBgn0259834
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 113/641 - (17%)
• Similarity: 208/641 - (32%)
• Gaps: 224/641 - (34%)

  Fly    40 DGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAI----SSLVGIV 100
            ||||||::.:...|.|.|:....:.:.:.:.|..:.....::|...|.:::.::    ..||.|:
Human    16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAII 80

  Fly   101 NGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFK 165
            ...:..:.|    ::.|..:...|..:|::.|:.....:.:..:.|:|........::....|||
Human    81 CDILGEKTT----SILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFK 141

  Fly   166 LKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAILCALTLQPVLWHVKKP 230
            .:...:|..:.:..||..:..| .:..|:..|...|.::::..||:|.:..::.|:|:  |:|
Human   142 KRLALSTAIARSGMGLTFLLAP-FTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPI--HIK-- 201

  Fly   231 EKPVHNTIEGIAETEKLQPELLEANGNLLSPSNDPWKDYECKYCQYQKRSKRGLFSSQYLFNVDD 295
                                         |.:|...||.
Human   202 -----------------------------SENNSGIKDK-------------------------- 211

  Fly   296 PERPGYEITEPGTPMLARANDGWFGSKLSLTSESAGGARS---RTRQALMR----QVSSRSRENL 353
                                    ||.||.....|....:   .|.::.::    |.:....:||
Human   212 ------------------------GSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNL 252

  Fly   354 DRLEQNRHDQGPDTPSAAALYKPNYFNREREDLDRYASKTSVYSRPGQDELLRCTCAE-DKALLQ 417
             .:.||:.::                               .|:.|.::.||..:..| ||.:..
Human   253 -TVSQNQSEE-------------------------------FYNGPNRNRLLLKSDEESDKVISW 285

  Fly   418 KTAESLQVNLFNNSADNTEAEEEAKRRMTFFQKVSKFFDLDLLRDF--TFVNLA----VGMSIMM 476
            ...:...::||.|               .||...:..|.|..|..|  ||..:|    :|:.||.
Human   286 SCKQLFDISLFRN---------------PFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMD 335

  Fly   477 FGEMNFSVLTPFILNSFGYTDTQISLVMS------------------LLACMDISVRFLAPLALE 523
                     ..::::..|..:| :|.::|                  |:.|.  ....|||||.
Human   336 ---------ASYLVSVAGILET-VSQIISGWVADQNWIKKYHYHKSYLILCG--ITNLLAPLAT- 387

  Fly   524 KVKLDNRVLFAFGILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLP 588
                      .|.:|        :.:|..:.|..|.:|             .||:|..|.|.|..
Human   388 ----------TFPLL--------MTYTICFAIFAGGYL-------------ALILPVLVDLCRNS 421

  Fly   589 AAS---GLQLIFNTIFSFAMGPILGILTEAYGYAATIHTINALTLLALLLWLAESV 641
            ..:   ||...|..:...:..||.|.|   |.|.   .|.|.....:.:.:|..||
Human   422 TVNRFLGLASFFAGMAVLSGPPIAGWL---YDYT---QTYNGSFYFSGICYLLSSV 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
out	NP_573378.1	MFS	44..>221	CDD:475125	31/180 (17%)
		MFS	<459..626	CDD:475125	41/193 (21%)
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	109/637 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		9/93 (10%)