DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment out and SLC16A2

DIOPT Version :9

Sequence 1:	NP_001285435.1	Gene:	out / 32926	FlyBaseID:	FBgn0259834	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_006508.2	Gene:	SLC16A2 / 6567	HGNCID:	10923	Length:	539	Species:	Homo sapiens

Alignment Length:	202	Identity:	48/202 - (23%)
Similarity:	84/202 - (41%)	Gaps:	22/202 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FVAPDGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQ-------SLGFDAKQTTTI-VNVVMA 92
            |..|:||:||||..||...|..:|......|::|.:.::       .:.|.|.....: :.::..
Human    92 FQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFF 156

  Fly    93 ISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATS 157
            .|.:|.|....:..|.|    |..|.::||:|:..|:|.::..........:||.|...|...:.
Human   157 CSPIVSIFTDRLGCRIT----ATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSL 217

  Fly   158 LAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYG-----AQGTILIYAGIAMNAILCA 217
            :.:..||    :|..|.:..:...|...|......|:...|     || |..:.:......:|.:
Human   218 VILGHYF----QRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQ-TFQVLSTFMFVLMLLS 277

  Fly   218 LTLQPVL 224
            ||.:|:|
Human   278 LTYRPLL 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
out	NP_001285435.1	MFS	45..>225	CDD:119392	43/193 (22%)
		MFS	<464..621	CDD:119392
		MFS_1	468..>621	CDD:284993
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		48/202 (24%)
		2A0113	86..513	CDD:273325	48/202 (24%)
		MFS	101..498	CDD:119392	43/193 (22%)
		DUF1564	<286..>334	CDD:284922
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750