Protein Alignment out and SLC16A1

DIOPT Version :10

• Sequence 1: NP_573378.1
• Gene: out / 32926
• FlyBaseID: FBgn0259834
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_003042.3
• Gene: SLC16A1 / 6566
• HGNCID: 10922
• Length: 500
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 121/641 - (18%)
• Similarity: 217/641 - (33%)
• Gaps: 216/641 - (33%)

  Fly    33 GP-DFVAPDGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSL 96
            || .:..|||||||.|.:.|.::..|.:...:...:.::...........:.:.|.::::|:...
Human     7 GPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYG 71

  Fly    97 VGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVN 161
            .|.::..:..::..|.|.:.|..|:..|:..::||.|..|..:|:..|.|:||...:......:.
Human    72 GGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIG 136

  Fly   162 TYFKLKRRRATG--------FSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAILCAL 218
            .||..:|..|.|        |..|:..|..:||        |.:|.:|:.||..|:.:|   |.:
Human   137 KYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFF--------GIFGWRGSFLILGGLLLN---CCV 190

  Fly   219 TLQPVLWHVKKPEKPVHNTIEGIAETEKLQPELLEANGNLLSPSNDPWKDYECKYCQYQKRSKRG 283
                                                                             
Human   191 ----------------------------------------------------------------- 190

  Fly   284 LFSSQYLFNVDDPERPGYEITEPGTPMLARANDGWFGSKLSLTSESAGGARSRTRQALMRQVSSR 348
                                                          ||        ||||.:
Human   191 ----------------------------------------------AG--------ALMRPI--- 198

  Fly   349 SRENLDRLEQNRHDQGPDTPSAAALYKPNYFNREREDLDRYASKTSVYSRPGQDELLRCTCAEDK 413
                           ||         ||                    ::.|:|        :.|
Human   199 ---------------GP---------KP--------------------TKAGKD--------KSK 211

  Fly   414 ALLQKTAES-LQVNLFNNSADNTEAEEEAKRRMTFFQKVSKFFDLDLLRDFTFVNLAVGMSIMMF 477
            |.|:|..:| ::.:|.:.:.|......:.::| :.||.:::|.||.|.....|:....|..||.|
Human   212 ASLEKAGKSGVKKDLHDANTDLIGRHPKQEKR-SVFQTINQFLDLTLFTHRGFLLYLSGNVIMFF 275

  Fly   478 GEMNFSVLTPFI-LNSFG----YTDTQISLVMSLLACMDISVRFLAPLALEKVKLDNRVLFAFGI 537
            |     :..|.: |:|:|    |:..:.:.::|:||.:|:..|....|......:..|:.:.|..
Human   276 G-----LFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAA 335

  Fly   538 LCIAVG--RVVVAFTDSYEIMIGVFLLIG-FGKAFRTIFSPLI--IPSYVPLNRLPAASGLQLIF 597
            ..:|.|  .::...:.:|   :|..:..| ||.||..:.|.|.  :...|...|..:|.||..|.
Human   336 SVVANGVCHMLAPLSTTY---VGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIV 397

  Fly   598 NTIFSFAMGPILGILTEAYG-YAATIHTINALTLLA-LLLWLAESVVRRILGIPSK 651
            .........|:||.|.:.|| |..|......:.::: :.|::...:..|:|....|
Human   398 ECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQK 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
out	NP_573378.1	MFS	44..>221	CDD:475125	40/184 (22%)
		MFS	<459..626	CDD:475125	45/177 (25%)
SLC16A1	NP_003042.3	2A0113	1..455	CDD:273325	121/641 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..500		121/641 (19%)