Protein Alignment out and SLC16A8

DIOPT Version :9

• Sequence 1: NP_001285435.1
• Gene: out / 32926
• FlyBaseID: FBgn0259834
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_037488.2
• Gene: SLC16A8 / 23539
• HGNCID: 16270
• Length: 504
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 124/639 - (19%)
• Similarity: 197/639 - (30%)
• Gaps: 244/639 - (38%)

  Fly    24 PKRRDKSDLGPDFVAPDGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDA--KQTTTI 86
            |:|.:    ||    |||||||||..|..:...|.:...:...:.:|..|:.  |||  ..|..:
Human     6 PRRGE----GP----PDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRD--FDAGYSDTAWV 60

  Fly    87 VNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGL 151
            .::::|:....|.|:..:..||..|.|.|.|..||..|:.|::|.|...:..:....:.|:||.|
Human    61 SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLAL 125

  Fly   152 AMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTV---LLGYYGAQGTILIYAGIAMNA 213
            ....:.:.:..||:.:|..|.|.:   ....|:|...:|.:   ||..:|.:|..|:..|:.::.
Human   126 NFQPSLIMLGLYFERRRPLANGLA---AAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHC 187

  Fly   214 ILCALTLQPVLWHVKKPEKPVHNTIEGIAETEKLQPELLEANGNLLSPSNDPWKDYECKYCQYQK 278
            ..|...::|
Human   188 CACGAVMRP-------------------------------------------------------- 196

  Fly   279 RSKRGLFSSQYLFNVDDPERPGYEITEPGTPMLARANDGWFGSKLSLTSESAGGARSRTRQALMR 343
                             |..||        |...|              :|||
Human   197 -----------------PPGPG--------PRPRR--------------DSAG------------ 210

  Fly   344 QVSSRSRENLDRLEQNRHDQGPDTPSAAALYKPNYFNREREDLDRYASKTSVYSRPGQDELLRCT 408
                              |:..|.|..|
Human   211 ------------------DRAGDAPGEA------------------------------------- 220

  Fly   409 CAEDKALLQKTAESLQVNLFNNSADNTEAEEEAKRRMTFFQKVSKFFDLDLLRDFTFVNLAVGMS 473
             ..|.|.||....|.:|              ..:||:         .||.:..|..|...||...
Human   221 -EADGAGLQLREASPRV--------------RPRRRL---------LDLAVCTDRAFAVYAVTKF 261

  Fly   474 IMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVR----FLAPLALEKVKLDNRVLFA 534
            :|..|....::|........|..||..:.::|::..:||..|    .||.||    :|...|.:.
Human   262 LMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLA----RLRPHVPYL 322

  Fly   535 FGILCIAVGRVVVAFTD-------SYEIMIGVFLLIGFGKAFRTI----FSPLIIPSYVPLNRLP 588
            |.:..:|.|     .||       ||..::.  ..:.||.::..:    |..|:.....|  |.|
Human   323 FSLALLANG-----LTDLSSARARSYGALVA--FCVAFGLSYGMVGALQFEVLMAAVGAP--RFP 378

  Fly   589 AASGLQLIFNTIFSFAMGPILGILTEAYGYAATIHTINALTLLALLLWLAESVV 642
            :|.||.|:..........|..|.|            ::.|....::.:||.|.|
Human   379 SALGLVLLVEAAAVLIGPPSAGRL------------VDVLKNYEIIFYLAGSEV 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
out	NP_001285435.1	MFS	45..>225	CDD:119392	46/184 (25%)
		MFS	<464..621	CDD:119392	40/171 (23%)
		MFS_1	468..>621	CDD:284993	39/167 (23%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	124/639 (19%)
		MFS	19..429	CDD:119392	114/618 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..224		13/190 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..504

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850