DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment out and gem-1

DIOPT Version :9

Sequence 1:	NP_001285435.1	Gene:	out / 32926	FlyBaseID:	FBgn0259834	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001379120.1	Gene:	gem-1 / 181458	WormBaseID:	WBGene00008214	Length:	771	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	148/749 - (19%)
Similarity:	251/749 - (33%)	Gaps:	229/749 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EKSSLTEKNHTQVYNDTTKPK--------KPKRRDKSD------LGPDFVAPDGGWGWVVCLAAG 52
            |..|...:::.|.::.:.:|:        ...|.|.||      |....|..|||:||:|.||:.
Worm    16 EDVSCWVEHNQQPFSPSDEPRVRFEAPAPVSARSDDSDAESVESLTERPVYKDGGYGWLVVLASF 80

  Fly    53 LNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVM------AISSLVGIVNGAMFRRFTFR 111
            |.:.....|...:|::: |::|. .|...:..:::...|      .:|.:.|||:..:..|.:.
Worm    81 LMHAVCDGASFCFGIVF-VKIQE-HFQCGRFVSMITASMFLSLPLIMSPVAGIVSDILGCRMSI- 142

  Fly   112 QVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMA----ATSLAVNTYFKLKRRRAT 172
               :.|.|:..:...::.||:..:.::|.    ||:|.|:.|:    |..:.|..||:.:|..||
Worm   143 ---IIGASICTVSCIIAMFCSHIFFFMIS----FGLGCGVGMSFIYNAAIVIVTYYFEKRRGLAT 200

  Fly   173 GFSWTITGLGPIFFP---QVSTVLLGYYGAQGTILIYAGIAMNAILCAL--TLQPVLWH------ 226
            .|:.:.||:|.:.:|   .:|.:.|..:.:...|::.....|..::..:  .::.|.|.
Worm   201 SFAVSGTGVGTVIYPILLNLSMIYLASFVSDIRIILIFFAVMYFVIAVIGFFIKDVEWESDKTDF 265

  Fly   227 ---------VKKPEKPVHNT-------------------------IEGIAETEKLQ--------- 248
                     .|..::..:||                         |:.|.:..|.:
Worm   266 KLRKFQKYIAKMDDEKENNTNPTDAFMRHAISLPNLNILNNHSGSIQSICDAAKAERKSDKPTRS 330

  Fly   249 ---------------PELLEANGNL-------LSPSNDPWKDYECKYCQYQKR------------ 279
                           ||....|.||       |..:|.|     |...:.|:|
Worm   331 KSVALFDNKHQMSSIPEYSMLNTNLANLEHLDLELANSP-----CTTVRAQRRRVISKVSMSVDQ 390

  Fly   280 ---------------------------------SKRGLFSSQYLF--NVDDP---------ERPG 300
                                             |..|..||..|.  |:|:|         |...
Worm   391 INELEDEAFHINLFQSSTESESDDESSSDDSEMSNDGDSSSSELSEKNLDEPTTKLINKNLENVA 455

  Fly   301 YEITEPGTPMLARANDGWFGSKLSLTSESAGGARSRTRQALMRQVSSRSRENLDRLEQNRHDQGP 365
            :..|. ..|..||.|.   .|..:.||...||     |......:.||...||..:.:
Worm   456 FRATS-SVPNSARMNR---NSVAAGTSNMFGG-----RVIASNAIQSRHATNLIAMGK------- 504

  Fly   366 DTPSAAALY-KPNYFNREREDLDRYASKTSVYSRPGQDELLRCTCAEDKAL----LQKTAESLQV 425
             .|||..|. :.|..:...:.:..:..|.....:|...|::.|......||    |....:...|
Worm   505 -IPSAPMLVARKNRKSMIGKPIQGFYKKWLETEKPIYQEVIHCRAYIYLALSVLCLYFILDVPYV 568

  Fly   426 NLFNNSADNTEAEEEAKRRMTFFQKVSKFFDLDL---LRDFTFVNL---------AVGMSIMMFG 478
            ..:..|.|..:.||.....:.:...:|.|..:.|   |.|:|..::         .||::||...
Worm   569 CFYEYSIDTLKMEESEANYIYYSIGISNFISVLLFGTLADWTRKHITTIYASSMVGVGITIMFST 633

  Fly   479 EMNFSVLTPFILNSFGYTDTQ------------------ISLVMSLLACMDISVRFLAP----LA 521
            .:|..|....:...||.|.|.                  ..:..||:|.::.....:.|    |.
Worm   634 RINSLVELVIVGVCFGVTITSNYVLQSILVTICFEDVNLFQVAYSLIAMIEGVASLIGPPIFALV 698

  Fly   522 LEKVKLDNRVLFAFGILCIAVGRVVVAFTDSYEI 555
            .|.......|.|..||..:|.|  ...|..|||:
Worm   699 REATGGYTVVFFISGIFALASG--FFGFMFSYEM 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
out	NP_001285435.1	MFS	45..>225	CDD:119392	43/194 (22%)
		MFS	<464..621	CDD:119392	27/123 (22%)
		MFS_1	468..>621	CDD:284993	26/119 (22%)
gem-1	NP_001379120.1	MFS	72..>254	CDD:421695	43/191 (23%)
gem-1	NP_001379120.1	MFS	<543..727	CDD:421695	38/185 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820