Protein Alignment out and SLC16A14

DIOPT Version :10

• Sequence 1: NP_573378.1
• Gene: out / 32926
• FlyBaseID: FBgn0259834
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_689740.2
• Gene: SLC16A14 / 151473
• HGNCID: 26417
• Length: 510
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 128/646 - (19%)
• Similarity: 218/646 - (33%)
• Gaps: 192/646 - (29%)

  Fly    27 RDKSDLGPDFVAP--DGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNV 89
            :||..|.|.   |  ||||.|::.|::...:..:..:....|::....::........|..:.::
Human    17 KDKKTLKPH---PNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSL 78

  Fly    90 VMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMA 154
            .|.|:.:||...|........||.|:.|..:..||..|||:........|......|:|.|:|..
Human    79 SMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYL 143

  Fly   155 ATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGY----YGAQGTILIYAGIAMNAIL 215
            ...:.|..||:.:|..|.|.|.|.||.|..    :.||||.|    ||.:..:||...:::|..:
Human   144 PAVVMVGRYFQKRRALAQGLSTTGTGFGTF----LMTVLLKYLCAEYGWRNAMLIQGAVSLNLCV 204

  Fly   216 CALTLQPVLWHVKKPEKPVHNTIEGIAETEKLQPELLEANGNLLSPS---NDPWKDYECKYCQYQ 277
            |...::|                                    |||.   |||           .
Human   205 CGALMRP------------------------------------LSPGKNPNDP-----------G 222

  Fly   278 KRSKRGLFSSQYLFNVDDPERPGYEITEPGTPMLARANDGWFGSKLSLTS-------ESAGGARS 335
            ::..|||           |......:...|........||..|::.:|..       :.||..::
Human   223 EKDVRGL-----------PAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKN 276

  Fly   336 RTRQALMRQVSSRSRENLDRLEQNRHDQGPDTPSAAALYKPNYFNREREDLDRYASKTSVYSRPG 400
            .....:::.||..:.    |:.:...|           :...||.
Human   277 MCALRILKTVSWLTM----RVRKGFED-----------WYSGYFG-------------------- 306

  Fly   401 QDELLRCTCAEDKALLQKTAESLQVNLFNNSADNTEAEEEAKRRMTFFQKVSKFFDLDLLRDFT- 464
                              ||     :||.|            |....|    .|:.|.....|.
Human   307 ------------------TA-----SLFTN------------RMFVAF----IFWALFAYSSFVI 332

  Fly   465 -FVNLAVGMSIMMFGEMN-----FSVLTPFILNSFGYTDTQISLVMSLLACMDI-SVRFLAPLAL 522
             |::|...:::....|.|     .|::.  |::.||..   |..|::.|.|:.: :|..||...|
Human   333 PFIHLPEIVNLYNLSEQNDVFPLTSIIA--IVHIFGKV---ILGVIADLPCISVWNVFLLANFTL 392

  Fly   523 EKVKLDNRVLFAFGILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRL 587
                    ||..|          ::....:|..:..:..||||...:.::. |::....|.:..|
Human   393 --------VLSIF----------ILPLMHTYAGLAVICALIGFSSGYFSLM-PVVTEDLVGIEHL 438

  Fly   588 PAASGLQLIFNTIFSFAMGPILG---ILTEAYGYAATIHTINALTLLALLLWLAESVVRRI 645
            ..|.|:.:..|.|.:....|..|   .:|:.|.:  :.:....|.::.:|..|.:..:|.|
Human   439 ANAYGIIICANGISALLGPPFAGWIYDITQKYDF--SFYICGLLYMIGILFLLIQPCIRII 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
out	NP_573378.1	MFS	44..>221	CDD:475125	45/180 (25%)
		MFS	<459..626	CDD:475125	36/177 (20%)
SLC16A14	NP_689740.2	MFS_MCT14	33..492	CDD:340987	117/620 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..255		11/62 (18%)