DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8051 and SLC16A5

DIOPT Version :9

Sequence 1:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_005257847.1	Gene:	SLC16A5 / 9121	HGNCID:	10926	Length:	545	Species:	Homo sapiens

Alignment Length:	578	Identity:	117/578 - (20%)
Similarity:	207/578 - (35%)	Gaps:	133/578 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PKNGSAGQTKIAPPTHTHSIAAASVPQKVPAKKKRDKSDLGEDFVAPDGGWGWLVSVASGVNILV 98
            |..|....::...|:.|....||:.....|.::::.:  :.:.....||.|.|:|.:|:.|...:
Human     4 PTRGPLATSQGWCPSVTPGTWAAATLAVRPWQRRQQR--MPQALERADGSWAWVVLLATMVTQGL 66

  Fly    99 TFALAQQFGILFRDRMAGLGISSSELTTIINTQIAVSAFTGLLNGPLFRRYTYRVVALVGSVLTF 163
            |.......||.|.:.......|:||.:...:...||....|.|...|..|:..||..::|.||..
Human    67 TLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLAS 131

  Fly   164 LGLFWMVFADTFAVYIMSFSILYGFGRGLTVSASSLAVNTYFKVKRRTATAFQFGVAGLGPIVCP 228
            ||:....|:...:....:...:.|.|...:..:|...:..||..:|..|.|.......||..:.|
Human   132 LGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWP 196

  Fly   229 YFATYMLYEFGVQGTTLLFAGASLHTIACSLIYQPVKWHVVKRDRDAEALQQVQPLAEREDQDED 293
            ..:.|:|...|.:||.|:|.|..||...|..|.:||...|....::...
Human   197 LLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPP---------------- 245

  Fly   294 IIKNVVEPETPVLPRANDGWFGSRASLNSVGTRNRLNTWEKSDSNGHVELKRLSSKDSNPGRQLR 358
                 ..||||.|        |..|:.                                 ||.:
Human   246 -----PPPETPAL--------GCLAAC---------------------------------GRTI- 263

  Fly   359 SISVSHSIKEEEATGYNSDHEVQHTELTEKEKQELEDEKERQRRKKLPFYMKVVIFFDMDLLRDI 423
                                                       ::.|.|          |:||..
Human   264 -------------------------------------------QRHLAF----------DILRHN 275

  Fly   424 T----YVNLAVGITLINFVEINFAILTPFILSDLGFNKDQIALAMSTLGFFDLVVRFLIPLITAK 484
            |    |: |.|..:::.| .:....|.|:.:.. ..::.|.||.:|.:||.::.:|.|..|:..:
Human   276 TGYCVYI-LGVMWSVLGF-PLPQVFLVPYAMWH-SVDEQQAALLISIIGFSNIFLRPLAGLMAGR 337

  Fly   485 -INLSNRTF-FVVGILGMCIGRMFLSMTSNFYVMMAIFLWLGLNKAFRTVFWSLIIPSYVPLKRL 547
             ...|:|.: |.:.:|...:..:..:.:.:|:|::...|...::.:........::...||:.:.
Human   338 PAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQF 402

  Fly   548 PAAAGLQLLMSGTFSMIFGPLIGLIRDHTS------YAVTLNLLNALCVMAFAGWYLE 599
            |.|.||..::.|...:|..||.||:.|.|:      |..:..|::|...|..:.:.|:
Human   403 PRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQ 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	50/179 (28%)
		MFS	<428..598	CDD:119392	39/177 (22%)
		MFS_1	440..>572	CDD:284993	29/133 (22%)
SLC16A5	XP_005257847.1	2A0113	41..493	CDD:273325	110/539 (20%)
SLC16A5	XP_005257847.1	MFS	54..452	CDD:119392	105/516 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145487
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850