DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8051 and Slc16a12

DIOPT Version :9

Sequence 1:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001178566.1	Gene:	Slc16a12 / 309525	RGDID:	1311468	Length:	486	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	103/524 - (19%)
Similarity:	180/524 - (34%)	Gaps:	128/524 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PDGGWGWLVSVASGVNILVTFALAQQFGILFRDRMAGLGISSSELTTIINTQIAVSAFTGLLNGP 144
            |||||||::.....:..:.|.|:.:...|.|.:.........|:...|.:....::.....|...
  Rat    13 PDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSV 77

  Fly   145 LFRRYTYRVVALVGSVLTFLGLFWMVFADTFAVYIMSFSILYGFGRGLTVSASSLAVNTYFKVKR 209
            :..:.:.:...::|.:|...||....||.:.....:|..:|.|.|..|..|.:...|..||..::
  Rat    78 VSNQLSCQAGIMLGGLLASTGLILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRK 142

  Fly   210 RTATAFQFGVA----GLGPIVCPYFATYMLYEFGVQGTTLLFAGASLHTIACSLIYQPVKWHVVK 270
                ||.:|:|    |:|..:.......::.:|..:|..|:..|..|:...|..:.:|:   .:|
  Rat   143 ----AFAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPI---TLK 200

  Fly   271 RDRDAEALQQVQPLAEREDQDEDIIKNVVEPETPVLPRANDGWFGSRASLNSVGTRNRLNTWEKS 335
            .|          |....:..|.|..:...:..:|..|...: |           |..||
  Rat   201 ED----------PSGPEKSHDRDAQREDCKQASPYSPLTKE-W-----------TETRL------ 237

  Fly   336 DSNGHVELKRLSSKDSNPGRQLRSISVSHSIKEEEATGYNSDHEVQHTELTEKEKQELEDEKERQ 400
                                       ..|:::    ||.
  Rat   238 ---------------------------CCSLQQ----GYG------------------------- 246

  Fly   401 RRKKLPFYMKVVIFFDMDLLRDITYVNLAVGITLINF-VEINFAILTPFILSDLGFNKDQIALAM 464
                         |.   |:.|  :|.|||.:..:.: ....|..|.|:.|| :|.:..|.|..|
  Rat   247 -------------FL---LMSD--FVVLAVSVLFMAYGCSPLFVYLVPYALS-VGVSHHQAAFLM 292

  Fly   465 STLGFFDLVVRFLIPLITAKINLSNRTF----FVVGILGMCIGRMFLSMTSNFYVMMAIFLWLG- 524
            |.||..|:|.......:|.:..|.|..:    |.|.:.|:|.  :.|.|..:|.:::......|
  Rat   293 SILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCY--LCLPMLQSFPLLVPFSCTFGY 355

  Fly   525 LNKAFRTVFWSLIIPSYVPLKRLPAAAGLQLLMSGTFSMIFGPLIGLIRDHT-SYAVTLNLLNAL 588
            .:.|:.|:. .::....|....|.:|.|:...:.....::..|:.|.:.|.| ||....    .|
  Rat   356 FDGAYVTLI-PVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAF----LL 415

  Fly   589 CVMA 592
            |..|
  Rat   416 CGFA 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	36/183 (20%)
		MFS	<428..598	CDD:119392	43/172 (25%)
		MFS_1	440..>572	CDD:284993	33/136 (24%)
Slc16a12	NP_001178566.1	2A0111	12..451	CDD:331689	103/524 (20%)
Slc16a12	NP_001178566.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..221		4/29 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850