DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8051 and Slc16a7

DIOPT Version :9

Sequence 1:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_058998.2	Gene:	Slc16a7 / 29735	RGDID:	3691	Length:	489	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	119/559 - (21%)
Similarity:	196/559 - (35%)	Gaps:	151/559 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SIAAASVPQKVPAKKKRDKSDLGEDFVAPDGGWGWLVSVASGVNILVTFALAQQFGILFRDRMAG 116
            |:.|.:.|...|              :.|||||||:|..||.::|..::|..:...:.|.|....
  Rat     6 SVKATAAPPPFP--------------LPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFNDIKDI 56

  Fly   117 LGISSSELTTIINTQIAVSAFTGLLNGPLFRRYTYRVVALVGSVLTFLGLFWMVFADTFAVYIMS 181
            ...:||::..|.:..:||....|.::..|...|..|.|.:||.:|...|:....|:.:.....::
  Rat    57 FKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLT 121

  Fly   182 FSILYGFGRGLTVSASSLAVNTYFKVKRRTATAFQFGVAGLGPI----VCPYFATYMLYEFGVQG 242
            ...:.|.|....:..:...:..||..||..|..  |.:|| .|:    :.| |..::...:|.:|
  Rat   122 VGFIGGLGLAFNLQPALTIIGKYFYRKRPLANG--FAMAG-SPVFLSTLAP-FNQFLFNSYGWKG 182

  Fly   243 TTLLFAGASLHTIACSLIYQPVKWHVVKRDRDAEALQQVQPLAEREDQDEDIIKNVVEPETPVLP 307
            :.|:.....||:.....:.:|                                   |.|.    |
  Rat   183 SFLILGAIFLHSCVAGCLMRP-----------------------------------VGPS----P 208

  Fly   308 RANDGWFGSRASLNSVGTRNRLNTWEKSDSNGHVELKRLSSKDSNPGRQLRSISVSHSIKEEEAT 372
            ||       ..|.:.||:|...:|            ||||           .:|.:..|..
  Rat   209 RA-------AKSKSKVGSRQDSST------------KRLS-----------KVSTAEKINR---- 239

  Fly   373 GYNSDHEVQHTELTEKEKQELEDEKERQRRKKLPFYMKVVIFFDMDLLRD---ITYVNLAVGITL 434
                                                     |.|..|...   :.|::..|.:.|
  Rat   240 -----------------------------------------FLDFGLFTHRGFLIYLSGNVVLFL 263

  Fly   435 INFVEINFAILTPFILSDLGFNKDQIALAMSTLGFFDLVVRFLIPLI--TAKINLSNRTFFVVGI 497
            ..|..|.|  |.|: ..|.|.:....|..:|.:.|.|:..|..:.||  |:.|....:..|.|.|
  Rat   264 GMFAPIIF--LAPY-AKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAI 325

  Fly   498 L--GMCIGRMFLSMTSNFYVMMAIFLWLGLNKAFRTVFWSLIIPSYVPLKRLPAAAGLQLLMSGT 560
            :  |:|.....|:.:....|:..||..:|.......:|..|:  ..|...|..:|.||..::. .
  Rat   326 MFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLM--DQVGASRFSSAVGLVTIVE-C 387

  Fly   561 FSMIFG-PLIGLIRDHTSYAVTLNLLNALCVMAFAGWYL 598
            ..::|| ||.|.:.|.|.....|.:.:.:.|:: :|.||
  Rat   388 CPVLFGPPLAGKLLDITGQYKYLYIASGIVVLS-SGIYL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	42/183 (23%)
		MFS	<428..598	CDD:119392	45/174 (26%)
		MFS_1	440..>572	CDD:284993	37/136 (27%)
Slc16a7	NP_058998.2	2A0113	21..436	CDD:273325	114/530 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..227		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850