DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8051 and Slc16a1

DIOPT Version :9

Sequence 1:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_036848.1	Gene:	Slc16a1 / 25027	RGDID:	3690	Length:	494	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	117/553 - (21%)
Similarity:	200/553 - (36%)	Gaps:	164/553 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 FVAPDGGWGWLVSVASGVNILVTFALAQQFGILFRDRMAGLGISSSELTTIINTQIAVSAFTGLL 141
            :..|||||||.|.|.:.::|..::|..:...:.|::.......::||::.|.:..:||....|.:
  Rat    11 YTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPI 75

  Fly   142 NGPLFRRYTYRVVALVGSVLTFLGLFWMVFADTFAVYIMSFSILYGFGRGLTVSASSLAVNTYFK 206
            :..|..:|..|.|.:.|..|:..||....|.:|.........::.|.|....::.:...:..||.
  Rat    76 SSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFY 140

  Fly   207 VKRRTATAFQFGVAG-------LGPIVCPYFATYMLYEFGVQGTTLLFAGASLH-TIACSLIYQP 263
            .||..|..  ..:||       |.|:...:|..     ||.:|:.|:..|..|: .:|.||
  Rat   141 KKRPLANG--LAMAGSPVFLSTLAPLNQAFFGI-----FGWRGSFLILGGLLLNCCVAGSL---- 194

  Fly   264 VKWHVVKRDRDAEALQQVQPLAEREDQDEDIIKNVVEPETPVLPRANDGWFGSRASLNSVGTRNR 328
                             ::|:..::.:.|.:                    .|:.||...|
  Rat   195 -----------------MRPIGPQQGKVEKL--------------------KSKESLQEAG---- 218

  Fly   329 LNTWEKSDSNGHVELKRLSSKDSNPGRQLRSISVSHSIKEEEATGYNSDHEVQHTELTEKEKQEL 393
                 |||:|..:                    :..|.|.|
  Rat   219 -----KSDANTDL--------------------IGGSPKGE------------------------ 234

  Fly   394 EDEKERQRRKKLPFYMKVVIFFDMDLLRDITYVNLAVGITLINFVEINFAILTPFI-LSDLG--- 454
                      ||..:..|..|.|:.|     :.:....:.|...|.:.|.:.||.: ||:.|
  Rat   235 ----------KLSVFQTVNKFLDLSL-----FTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSK 284

  Fly   455 -FNKDQIALAMSTLGFFDLVVRFLIPLI--TAKINLSNRTFFVVGIL--GMCIGRMFLSMTSNFY 514
             |:.::.|..:|.|.|.|:|.|..:.|.  |..|....:.||...::  |:|   ..|:..|..|
  Rat   285 HFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVC---HLLAPLSTTY 346

  Fly   515 VMMAI--------FLWLGLNKAFRTVFWSLIIPSYVPLKRLPAAAGLQLLMSGTFSMIFGPLIGL 571
            |...|        |.||. :..|.|:. .|:.|     :|..:|.||..::.....::..||:|.
  Rat   347 VGFCIYAGVFGFAFGWLS-SVLFETLM-DLVGP-----QRFSSAVGLVTIVECCPVLLGPPLLGR 404

  Fly   572 IRD------HTSYAVTLNLLNALCVMAFAGWYL 598
            :.|      :|.:|..:       ::..||.||
  Rat   405 LNDMYGDYKYTYWACGV-------ILIIAGLYL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	43/187 (23%)
		MFS	<428..598	CDD:119392	47/192 (24%)
		MFS_1	440..>572	CDD:284993	40/148 (27%)
Slc16a1	NP_036848.1	2A0113	1..462	CDD:273325	117/553 (21%)
Slc16a1	NP_036848.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750