DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8051 and Slc16a4

DIOPT Version :9

Sequence 1:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_666248.1	Gene:	Slc16a4 / 229699	MGIID:	2385183	Length:	500	Species:	Mus musculus

Alignment Length:	569	Identity:	114/569 - (20%)
Similarity:	199/569 - (34%)	Gaps:	173/569 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 KRDKSDLGEDFVAP-DGGWGWLVSVASG-VNILV-----TFALAQQFGILFRDRMAGLGISSSEL 124
            |::|:.  ..:..| ||||||:|.:... ||:.|     |||:   |.::|::...|   :|.::
Mouse     3 KKEKTP--SPYTKPLDGGWGWMVVLHFFLVNVFVMGMTKTFAI---FFVVFQEEFEG---TSEQI 59

  Fly   125 TTI--INTQIAVSAFTGLLNGPLFRRYTYRVVALVGSVL-----TFLGLF----------WMVFA 172
            ..|  |.:.:..||      |||        .|::..||     :.||.|          |   |
Mouse    60 GWIGSIMSSLRFSA------GPL--------AAIICDVLGEKATSILGTFLVSGGYVISSW---A 107

  Fly   173 DTFAVYIMSFSILYGFGRGLTVSASSLAVNTYFKVKRRTATAFQFGVAGLGPIVCPYFATYMLYE 237
            .......::..:|.|.|.......:::.:..|||.:...:||......||..::.| |..:::..
Mouse   108 TGIPFLCVTMGLLPGLGSAFLYQVAAVVITKYFKKRLGLSTAIARSGMGLTFLLAP-FTKFLIDL 171

  Fly   238 FGVQGTTLLFAGASLHTIACSLIYQPVKWHVVKRDRDAEALQQVQPLAEREDQDEDI-----IKN 297
            :...|..:||....|:.:..|::                    ::|:..:.:.:.||     |.:
Mouse   172 YDWTGALILFGAIILNLVPSSML--------------------LRPIHSQSNNNSDIENKGSILS 216

  Fly   298 VVEPETPVLPRANDGWFGSRASLNSVGTRNRLNTWEKSDSNGHVELKRLSSKDSNPGRQLRSISV 362
            ..|||...                            |::::...|.:....|||.
Mouse   217 ATEPEASY----------------------------KTETSKCKETQEPFIKDST---------- 243

  Fly   363 SHSIKEEEATGYNSDHEVQHTELT--EKEKQELEDEKERQRRKKLPFYM--------KVVIFFDM 417
              ..|.|:.|          |.||  ..:.:|..:...|.|    |..|        |.|.:...
Mouse   244 --MKKSEQPT----------TTLTVLGNQSEEFSNRPHRNR----PLLMSNGKSHKKKFVSWNCK 292

  Fly   418 DLLRDITYVNLAVGITLINFVEINFAILT-PFILSDLGF--NKDQIALAMSTLGFFDLVVRFLIP 479
            ..|.||:.           |....|.|.| .|:||.|.:  ....:.....|||...:...:|:.
Mouse   293 QKLLDISL-----------FRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDVMDASYLVS 346

  Fly   480 L--ITAKI-----------NLSNRTFFVVGILGMC-IGRMFLSMTSNFYVMMAIFLWLGLNKAFR 530
            :  ||..:           |...:..:....|.:| :..:...:.:.|.::||..:...:   |.
Mouse   347 VAGITETVSQLISGWIADQNWIKKYQYHKSYLILCGVTNLLAPLATTFPLLMAYTILFAI---FA 408

  Fly   531 TVFWSLIIPSYVPL---KRLPAAAGLQLLMSGTFSMIFGPLIGLIRDHT 576
            ..:.:||:|..|.|   .|:....|.....:|...:...|:.|.|.|:|
Mouse   409 GGYLALILPVLVDLSKNSRVHKFLGYASFFAGIAVLSGPPIAGWIYDYT 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	44/202 (22%)
		MFS	<428..598	CDD:119392	34/169 (20%)
		MFS_1	440..>572	CDD:284993	30/151 (20%)
Slc16a4	NP_666248.1	2A0113	7..479	CDD:273325	112/565 (20%)
Slc16a4	NP_666248.1	MFS	24..482	CDD:119392	104/546 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750