DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8034 and SLC16A3

DIOPT Version :9

Sequence 1:	NP_573376.2	Gene:	CG8034 / 32924	FlyBaseID:	FBgn0031011	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001035887.1	Gene:	SLC16A3 / 9123	HGNCID:	10924	Length:	465	Species:	Homo sapiens

Alignment Length:	477	Identity:	115/477 - (24%)
Similarity:	179/477 - (37%)	Gaps:	106/477 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 APDGGWGWVACFGVSLVNLATRSIEPSFGLLFGDTLKELNVGTTGAAVIISALDVCMNFSGLFVG 74
            ||||||||...||..::...:.:...:..:.|.:.::|..:|.:..|.|.|.|...:..:|....
Human    15 APDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCS 79

  Fly    75 PLLKEFSYRKVAIAGSLLCGLGLALTSPATSMAHILSTYSVINGIGVGLSTSAAFVALNHYFKHK 139
            ..:..|..|.|.:.|.|...||:...|...|:..:..|..||.|:|:.|:...:.:.||.||..:
Human    80 VCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKR 144

  Fly   140 RGQAVGLSMAGTAMGMLIMPQLVRILLEAYDFRGAVLLLAGVALNATVGSVLLQPVKWHMKEEFD 204
            |..|.||:.||:.:.:..:..|.::|.:.|.:||..|:|.|:.||..|.:.|::|
Human   145 RPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRP---------- 199

  Fly   205 DEELMCISALP---TPQP-----QLTVGGAGG------AASAGA------PVFKV--IKEDGNEE 247
                :.::|.|   .|:|     .|:|....|      |||...      |||.|  .|:.|..:
Human   200 ----LVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPD 260

  Fly   248 DALPEMNTLLFHKPHPHQHSMRKNYSEMAMNTMNGSRLGIPK-RP----TFPRIMSLAGVQSAAH 307
            .....:.|:|             .:.::......|...|:.| ||    .|...|...|:...|.
Human   261 TKAAFLLTIL-------------GFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAG 312

  Fly   308 GAGGDSGGYT--------SQAEVNATQLRCRKASV------------------------TSNLSY 340
            ...||.||..        |...|.|.|.....|.|                        .|....
Human   313 STAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKL 377

  Fly   341 MDFTGSILQVHLNTGDDEFEQNDRELRRVGTATGSIVLGGHRDSFIKMKPTELDKQAEAAAALDE 405
            :|.|...:.|.:..|.:             ..|.|::|.......|:.||.|  .|.|.|||.:|
Human   378 LDATHVYMYVFILAGAE-------------VLTSSLILLLGNFFCIRKKPKE--PQPEVAAAEEE 427

  Fly   406 EAKKKAKKPGFWRRFADLLDID 427
            :..|.....|     .||.:::
Human   428 KLHKPPADSG-----VDLREVE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8034	NP_573376.2	MFS	20..>197	CDD:119392	48/176 (27%)
		MFS	<437..583	CDD:119392
		MFS_1	437..>581	CDD:284993
SLC16A3	NP_001035887.1	2A0111	8..444	CDD:331689	115/475 (24%)
SLC16A3	NP_001035887.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..438		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020