DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8034 and CG12866

DIOPT Version :9

Sequence 1:	NP_573376.2	Gene:	CG8034 / 32924	FlyBaseID:	FBgn0031011	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	131/627 - (20%)
Similarity:	228/627 - (36%)	Gaps:	118/627 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VAPDGGWGWVACFGVSLVNLATRSIEPSFGLLFGDTLKELNVGTTGAAVIISALDVCMNFSGLFV 73
            :.||||:|||......|..|....:..:.|:|.....::|:|..:..:.:.|....|...||.|.
  Fly   297 IPPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFS 361

  Fly    74 GPLLKEFSYRKVAIAGSLLCGLGLALTSPATSMAHILSTYSVI---NGIGVGLSTSAAFVALNHY 135
            ..|:..|.:|||||||.|...:.:..:|.:.|:..::..|||:   .||.:.:..:::.:.:.:|
  Fly   362 AVLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYY 426

  Fly   136 FKHKRGQAVGLSMAGTAMGMLIMPQLVRILLEAYDFRGAVLLLAGVALNATVGSVLLQPVKWHMK 200
            |:..|..|.|.|.:|...|:::...|...|:....:|..:...||:.:     .:||..|.:
  Fly   427 FERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIM-----LILLMVVAY--- 483

  Fly   201 EEFDDEELMCISALPTPQPQLTVGGAGGAAS----AGAPVFKVIKEDGNEEDALPEMNTLLFHKP 261
                      :...||......:.|:...:|    ....|...:::......:...::|   ::|
  Fly   484 ----------VEVAPTQVGMYHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILST---YEP 535

  Fly   262 HPHQHSMRKNYSEMAMN--------TMNGSRLGIPKRPTFPRIMSLAGVQSAAHGAGGDSGGYTS 318
            .|.:....| :.....|        :.|.....:..||.......|.               ||.
  Fly   536 RPKKKGCAK-FCPSCSNCCWRRRKKSQNADEQNLLIRPAPLEREDLF---------------YTG 584

  Fly   319 QAEVNATQLRCRKASVTSNLSYMDFTGSILQVHLNTGDDEFEQNDRELRRVGTATGSIVLGGHRD 383
            .||.       .|.....|:...:|        |..|.|:..|.              |..|.::
  Fly   585 PAEY-------EKPHSKENVDGKEF--------LLMGSDKNTQQ--------------VNYGIKN 620

  Fly   384 SFIKMKPTELDKQAEAAAALDEEAKKK--AKKPGFWRRFADLLDIDMLKDKMFLNLLFGLSIFYV 446
            ..:..:|..:.:........:|..||:  .:...|......|.|..:||...|..|:....:|
  Fly   621 IRVDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLFDYRLLKQFEFKILVASAFLF-- 683

  Fly   447 AEMNFKMVTPFFFANLGYQKTDVAFCLSITAITDIAARIVLPPIFDRTTIKKRTIFL----VSII 507
             .|.|.:  ||.::: ......|.:...|..|..| :.:|:..|......|:|:..|    ..:|
  Fly   684 -PMGFNI--PFVYSS-ARTTIPVEYARMIGPIIGI-SNLVMRNILGILAYKRRSWTLGLCGCGLI 743

  Fly   508 FVALTRSIMA---EQTEWTQLMIWLS------ICGFFRGSALSNFTLTVSEYCSLEKLPSAFGWH 563
            |..::..|.|   |...|.|.:...|      :....||       |...:|..|.||.:|||..
  Fly   744 FGGVSVLISAFYGENLIWFQFLYGFSYAVAPAVYSTLRG-------LIYVKYLGLSKLTNAFGIT 801

  Fly   564 --LVGKALFVIT--FGPLIGLIRDVTDSYPICIHTQSVCIMI 601
              .:|...|:.|  .|.|||    :|.:|........:|:::
  Fly   802 SLAMGMGAFIGTTIAGKLIG----ITGNYSAAFCFAGLCLIV 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8034	NP_573376.2	MFS	20..>197	CDD:119392	44/179 (25%)
		MFS	<437..583	CDD:119392	40/162 (25%)
		MFS_1	437..>581	CDD:284993	40/160 (25%)
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	44/193 (23%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	43/181 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920