DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8034 and gem-1

DIOPT Version :9

Sequence 1:	NP_573376.2	Gene:	CG8034 / 32924	FlyBaseID:	FBgn0031011	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001379120.1	Gene:	gem-1 / 181458	WormBaseID:	WBGene00008214	Length:	771	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	137/743 - (18%)
Similarity:	270/743 - (36%)	Gaps:	157/743 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RKVAPDGGWGWVACFGVSLVNLATRSIEPSFGLLFGDTLKELNVGTTGAAVIIS---ALDVCMNF 68
            |.|..|||:||:......|::.........||::|....:....|...:.:..|   :|.:.|:.
Worm    63 RPVYKDGGYGWLVVLASFLMHAVCDGASFCFGIVFVKIQEHFQCGRFVSMITASMFLSLPLIMSP 127

  Fly    69 SGLFVGPLLKEFSYRKVAIAGSLLCGLGLALTSPATSMAHILSTYSVINGIGVGLSTSAAFVALN 133
            ....|..:|   ..|...|.|:.:|.:...:....:.:...:.::.:..|:|:....:||.|.:.
Worm   128 VAGIVSDIL---GCRMSIIIGASICTVSCIIAMFCSHIFFFMISFGLGCGVGMSFIYNAAIVIVT 189

  Fly   134 HYFKHKRGQAVGLSMAGTAMGMLIMPQLVR---ILLEAY--DFRGAVLLLAGVALNATVGSVLLQ 193
            :||:.:||.|...:::||.:|.:|.|.|:.   |.|.::  |.|..::..|.:.....|....::
Worm   190 YYFEKRRGLATSFAVSGTGVGTVIYPILLNLSMIYLASFVSDIRIILIFFAVMYFVIAVIGFFIK 254

  Fly   194 PVKWHM-KEEF------------DDE--------ELMCISALPTPQPQLTVGGAGGAASAGAPVF 237
            .|:|.. |.:|            |||        :.....|:..|...:....:|...|    :.
Worm   255 DVEWESDKTDFKLRKFQKYIAKMDDEKENNTNPTDAFMRHAISLPNLNILNNHSGSIQS----IC 315

  Fly   238 KVIKEDGNEEDALPEMNTLLFHKPHPHQHSMRKNYSEMAMNTMNGSRLGI------------PKR 290
            ...|.:...:......:..||  .:.||.|....||.:..|..|...|.:            .:|
Worm   316 DAAKAERKSDKPTRSKSVALF--DNKHQMSSIPEYSMLNTNLANLEHLDLELANSPCTTVRAQRR 378

  Fly   291 PTFPRI-MSLAGV-------------QSAAHGAGGD----------SGGYTSQAEVN-------A 324
            ....:: ||:..:             ||:......|          :.|.:|.:|::       .
Worm   379 RVISKVSMSVDQINELEDEAFHINLFQSSTESESDDESSSDDSEMSNDGDSSSSELSEKNLDEPT 443

  Fly   325 TQLRCRKASVTSNLSYMDF--TGSILQVHLNTGDDEFEQNDRELRRVGTATGSIVLGGHR----D 383
            |:|      :..||..:.|  |.|:             .|...:.|...|.|:..:.|.|    :
Worm   444 TKL------INKNLENVAFRATSSV-------------PNSARMNRNSVAAGTSNMFGGRVIASN 489

  Fly   384 SFIKMKPTELDKQAEAAAALDEEAKKKAK----KP--GFWRRFADL---LDIDMLKDKMFLNL-L 438
            :......|.|....:..:|....|:|..|    ||  ||::::.:.   :..:::..:.::.| |
Worm   490 AIQSRHATNLIAMGKIPSAPMLVARKNRKSMIGKPIQGFYKKWLETEKPIYQEVIHCRAYIYLAL 554

  Fly   439 FGLSIFYVAEMNFKMVTPFFFANLGYQKTDVAFCLSITAITDIAARIVLPPIFDRTTIKKRTIFL 503
            ..|.::::.::.:.....:....|..::::..:......|::..:.::...:.|.|.....||:.
Worm   555 SVLCLYFILDVPYVCFYEYSIDTLKMEESEANYIYYSIGISNFISVLLFGTLADWTRKHITTIYA 619

  Fly   504 VSIIFVALTRSIMAEQTEWTQLMIWLSICGFFRGSALSNFTL-----------------TVSEYC 551
            .|::.|.:|...........:|:| :.:|  |..:..||:.|                 ..|...
Worm   620 SSMVGVGITIMFSTRINSLVELVI-VGVC--FGVTITSNYVLQSILVTICFEDVNLFQVAYSLIA 681

  Fly   552 SLEKLPSAFGWHLVGKALFVITFGPLIGLIRDVTDSYPICIHTQSVCIMICATAWG-IEYLVEYI 615
            .:|.:.|..|             .|:..|:|:.|..|.:......    |.|.|.| ..::..|.
Worm   682 MIEGVASLIG-------------PPIFALVREATGGYTVVFFISG----IFALASGFFGFMFSYE 729

  Fly   616 QSRRRTADAAQLPTQDVGATTTATSDQN 643
            .::|.|.|...:   :.|..|..|:..|
Worm   730 MNKRNTGDKDSI---ESGKPTELTNGNN 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8034	NP_573376.2	MFS	20..>197	CDD:119392	37/184 (20%)
		MFS	<437..583	CDD:119392	25/163 (15%)
		MFS_1	437..>581	CDD:284993	24/161 (15%)
gem-1	NP_001379120.1	MFS	72..>254	CDD:421695	38/184 (21%)
gem-1	NP_001379120.1	MFS	<543..727	CDD:421695	32/203 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820