DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8028 and SLC16A5

DIOPT Version :9

Sequence 1:	NP_001097031.2	Gene:	CG8028 / 32923	FlyBaseID:	FBgn0031010	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	XP_005257847.1	Gene:	SLC16A5 / 9121	HGNCID:	10926	Length:	545	Species:	Homo sapiens

Alignment Length:	535	Identity:	125/535 - (23%)
Similarity:	186/535 - (34%)	Gaps:	138/535 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQSRPAYQMKKSKSYTLEAPDGGWGILVCI------GMALPFTSALAALPSFGLVFGEFLKSIGA 73
            |..||..:.::.....||..||.|..:|.:      |:.|.|.:.:      |:.|.|......|
Human    29 LAVRPWQRRQQRMPQALERADGSWAWVVLLATMVTQGLTLGFPTCI------GIFFTELQWEFQA 87

  Fly    74 ETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSV 138
            ..|..:...|...:.:..||.....|..|||.|...:.||:|..||    :.|:|..|.:.....
Human    88 SNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG----MVASSFSHNLSQLYF 148

  Fly   139 VQGFAFGLMVPTCY------TTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGC 197
            ..||..||.:  |:      |....|||:.||:..:.|...:.||..|:|::.:.|:...|:||.
Human   149 TAGFITGLGM--CFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGT 211

  Fly   198 LLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEEQEELKELSPTVVIRVQPETP----LKATREE 258
            .|:..|:..|......::.||     ...:.|    |.||..|.     .||||    |.|....
Human   212 FLVFGGIFLHCCICGAIIRPV-----ATSVAP----ETKECPPP-----PPETPALGCLAACGRT 262

  Fly   259 PNFHTADPGARKLSHAEEQMLKVLSSRASSITSLGNWSGPVVVSDASPQ-------MMHSLQTSR 316
            ...|.|....|..:.....:|.|:            ||   |:....||       |.||
Human   263 IQRHLAFDILRHNTGYCVYILGVM------------WS---VLGFPLPQVFLVPYAMWHS----- 307

  Fly   317 RPSTIAGASGAVAPAHATKKSWVRTIVDFLDLTLLKKPI-FVNIVLGITFALYSDITFFTMQPVY 380
                                      ||.....||...| |.||.|.....|.:....|.....|
Human   308 --------------------------VDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKY 346

  Fly   381 LFELGYSRPDTATIIAIGAAADLASRIFLAITAVCIQVPSRYIYLAGAVFTVFARFAFNGITQFV 445
            ||.|.........::.      .||..|..:...|:                    |::     |
Human   347 LFSLALLLNGLTNLVC------AASGDFWVLVGYCL--------------------AYS-----V 380

  Fly   446 GMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDY 510
            .|:.|.|:|.           .|..|.:|.::|....|||..:.|.|..:..|:.|.:.|.|.::
Human   381 SMSGIGALIF-----------QVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNF 434

  Fly   511 IFVFHILNGFMILCA 525
            .:||::.:.|:|..|
Human   435 SYVFYMSSFFLISAA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8028	NP_001097031.2	MFS	40..>215	CDD:119392	48/186 (26%)
SLC16A5	XP_005257847.1	2A0113	41..493	CDD:273325	122/523 (23%)
SLC16A5	XP_005257847.1	MFS	54..452	CDD:119392	117/510 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7473
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920