DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8028 and SLC16A6

DIOPT Version :9

Sequence 1:	NP_001097031.2	Gene:	CG8028 / 32923	FlyBaseID:	FBgn0031010	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	XP_005257846.2	Gene:	SLC16A6 / 9120	HGNCID:	10927	Length:	527	Species:	Homo sapiens

Alignment Length:	557	Identity:	132/557 - (23%)
Similarity:	229/557 - (41%)	Gaps:	93/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KSKSYTLEAPDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSM 89
            |:..|| |.||||||..|.:............:.:||:.|.:.:.|.....|.::.|.|.....:
Human    15 KANVYT-EVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVL 78

  Fly    90 SFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQG----FAFGLMVPT 150
            :|:...:..|..|||.|.|.:.||:|...|.....|:....|:.:|..::.|    |:|   :||
Human    79 TFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSF---LPT 140

  Fly   151 CYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI--LTGLNAHAVFGML 213
             .|..:.||.|.|.:..:.|.|........:...:..|....|:|..||.  |..||. .:||.|
Human   141 -VTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNI-VIFGAL 203

  Fly   214 VMHPVEWHMRRVPIQPEEQEELKELSPTVVI---RVQPETPLKATREEPNFHTADPGARKLSHAE 275
             :.|:   ..|.|           .||.:||   |.:.:..|:..:...:..:.|.|..
Human   204 -LRPI---FIRGP-----------ASPKIVIQENRKEAQYMLENEKTRTSIDSIDSGVE------ 247

  Fly   276 EQMLKVLSSRASSITSLGNWSGPVVVSDASPQMMHSLQTSRRPSTIAGASGAVAPAHATKKSWVR 340
                  |::...::.:..|    :.:...:......::||.|||              .||:
Human   248 ------LTTSPKNVPTHTN----LELEPKADMQQVLVKTSPRPS--------------EKKA--- 285

  Fly   341 TIVDFLDLTLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYS----RPDTATIIAIGAAA 401
               ..||.::||:..|:...|   |.|::.:.||. ..:|:..||.|    :...|.:::..|.|
Human   286 ---PLLDFSILKEKSFICYAL---FGLFATLGFFA-PSLYIIPLGISLGIDQDRAAFLLSTMAIA 343

  Fly   402 DLASRIFLAITAVCIQVPSR--YIYLAGAVFTVFARFAFNGITQFVGMACITAVIGFLRTWL--- 461
            ::..||....  |..:.|.|  ||.|...:....:.|||...|:|.|:...:...||:...:
Human   344 EVFGRIGAGF--VLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGT 406

  Fly   462 HVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHILNGFMILCAA 526
            |:|| |...|.:..|:.::..|:::|||..|.....|:.|.:.|:::.|...|:       .|||
Human   407 HIPL-LAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFY-------SCAA 463

  Fly   527 PWVLEVLIVKFRRRNKI----ERNNVDHEDVDNQGRS 559
            ...|..:.:...|..|:    ..::.:.:.|.::|::
Human   464 GMALAAVCLALVRPCKMGLCQHHHSGETKVVSHRGKT 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8028	NP_001097031.2	MFS	40..>215	CDD:119392	45/180 (25%)
SLC16A6	XP_005257846.2	2A0113	23..512	CDD:273325	128/548 (23%)
SLC16A6	XP_005257846.2	MFS	33..476	CDD:119392	117/512 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7473
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810