DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8028 and slc16a12b

DIOPT Version :9

Sequence 1:	NP_001097031.2	Gene:	CG8028 / 32923	FlyBaseID:	FBgn0031010	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001139286.1	Gene:	slc16a12b / 449947	ZFINID:	ZDB-GENE-050522-80	Length:	488	Species:	Danio rerio

Alignment Length:	567	Identity:	125/567 - (22%)
Similarity:	208/567 - (36%)	Gaps:	146/567 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RLQSRPAYQMKKSKSYTLEAPDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAM 78
            ::..|..|..::.|...:..||||||.::..|..:......|......:.|.||......:.|..
Zfish     4 KVVGRTDYMAQEKKKGGVLPPDGGWGWMIVAGCFVVTVCTRAVTRCISIFFVEFQMHFAKDYSGT 68

  Fly    79 AIITSAF-FSSMSFAGLFSGSLF-QRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQG 141
            |.|.|.. .::|..|.|  |||. .:...|...:.||.|..:|..:..||||..:|.....::.|
Zfish    69 AWIHSLVDCTTMLCAPL--GSLIGNQLSCRIAVILGGFLASVGLVLSSFATSLEYLYATLGLLTG 131

  Fly   142 FAFGLMVPTCYT----TFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILT 202
            ..|.|    |||    ....||.:.:.:....|.:..|:|:.:...|:|.|:..|.:||.||||.
Zfish   132 LGFAL----CYTPAIAMVGIYFCERKALAYGIAMSGSGIGTFILAPVVQLLIEHYSWRGALLILG 192

  Fly   203 G--LNAHAVFGMLVMHPVEWHMRRVPIQPEEQEELKELSPTVVIRVQPETPLKATREEPNFHTAD 265
            |  ||. .|.|.|                        |.| ::::.:...||... .|..:....
Zfish   193 GFVLNL-CVCGAL------------------------LRP-IILKEEEACPLPVD-SECGYSVKP 230

  Fly   266 PGARKLSHAEEQMLKVLSSRASSITSLGNWSGPV--VVSDASPQMMHSLQTSRRPSTIAGASGAV 328
            |...                          .||.  ..|||..:...|:|
Zfish   231 PTLN--------------------------GGPTRSAASDAKQRCFQSMQ--------------- 254

  Fly   329 APAHATKKSWVRTIVDFLDLTLLKKPIFVNIVLGITFALYS---DITFFTMQPVYLFELGYSRPD 390
                              :...|..|.|  :||..:|.|.:   .:.|..:.| |..::|.....
Zfish   255 ------------------EYHFLLMPDF--LVLAGSFLLLASGCSLPFVYLVP-YALDVGVGHQH 298

  Fly   391 TATIIAIGAAADLASRI-FLAIT-AVCIQVPSRYIYLAGAVFTVFARFAFNGITQFVGMACITAV 453
            .|.:::|....|:...| |..:| ..|::......|:          ||..    ..|:.|:  .
Zfish   299 AAFLMSILGVIDIVGNITFGWLTDRRCLKKYRNICYM----------FAVG----MEGLCCL--F 347

  Fly   454 IGFLRT--WLHVP---------------LPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVG 501
            |..|||  || ||               :|:|.:|.:.::..::..|:..|:......:..||.|
Zfish   348 IPLLRTFVWL-VPFSVLYGYFDGAYVALIPVVTSDVVGRQYLSSALGVVYFLHAVPYLVSPPIGG 411

  Fly   502 FIRDKTRDYIFVFHILNGFMILCAAPWVLEVLIVKFRRRNKIERNNV 548
            ::.|.|..|...| .|:||.::.::..:..|.|:::.:||: ::|::
Zfish   412 WLVDTTGTYTATF-FLSGFALISSSLLLFSVAIIRYCQRNQ-KKNSL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8028	NP_001097031.2	MFS	40..>215	CDD:119392	52/182 (29%)
slc16a12b	NP_001139286.1	MFS	33..430	CDD:119392	110/509 (22%)
slc16a12b	NP_001139286.1	MFS_1	37..407	CDD:284993	100/481 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920