DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8028 and hrm

DIOPT Version :9

Sequence 1:	NP_001097031.2	Gene:	CG8028 / 32923	FlyBaseID:	FBgn0031010	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001286141.1	Gene:	hrm / 35499	FlyBaseID:	FBgn0033028	Length:	658	Species:	Drosophila melanogaster

Alignment Length:	650	Identity:	149/650 - (22%)
Similarity:	250/650 - (38%)	Gaps:	117/650 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TIEHRLQSRPAYQMKKSKSYTLEAPDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAE 74
            |.|.|.::......|..|.|.|..||||||.||.:|..|........:.|||::|.||..:..:.
  Fly    26 TNESRHKTVSLINKKDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSS 90

  Fly    75 TSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVV 139
            .:..|.|.:..:...|..|..|..|..::..|.|.:.||....||..:..:|:|...|.:::.|:
  Fly    91 PTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVL 155

  Fly   140 QGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 204
            .|...||..|........||.|.|.:......:...|||::.|.:::.|:..||:.|..||:.|:
  Fly   156 VGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGI 220

  Fly   205 NAHAVFGMLVMHPVEWHMRRVPIQPEEQEELKELSPTVVI----RVQPETPLKATREEPNFHTAD 265
            ..:.....|...|||.||.|||...:..|.:.|.....::    .|....|.....::|......
  Fly   221 TLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNS 285

  Fly   266 PGARKLSHAEEQMLKVLSSRASSITSLGNWSG------------PVVVSDA----SPQMMHS--- 311
            |.:......:|::..|.|:.|:.:.|... ||            ||.:...    :|..::|
  Fly   286 PPSPLYLPGDERLQFVRSASAAVVQSYSK-SGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSS 349

  Fly   312 ---------------LQTS-------RRPSTIA-----------------------------GAS 325
                           |:.|       |.|||.:                             |:|
  Fly   350 LYAVPEGRSSSNKLTLRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSS 414

  Fly   326 GAVAPAHATKKSWVRTIVD------------FLDLTLLKKPIFVNIVLGITFALYSDITFFTMQP 378
            |......:|.:......||            |.||:|||.|:::.|::..:....|...|..:.|
  Fly   415 GTGHAGDSTGQDGSYADVDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLP 479

  Fly   379 VYLFELGYSRPDTATIIAIGAAADLASRIFLAITAVCIQVPSRYIYLAG----AVFTVFARFAFN 439
            .:....|:::..:|.::::.:|.||..||..:..:....:|..:.::.|    .:......||:.
  Fly   480 SFGEARGFNKSLSAYLLSVVSATDLIGRIGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAWT 544

  Fly   440 GITQFVGMACITAVIGFLRTWLHVPL-PLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFI 503
                 ....|....:..|.:.::|.: .::.||.|..||..:.||:.:|:.|....:..|:..:.
  Fly   545 -----YSSVCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYW 604

  Fly   504 RDKTRDYIFVFHILNGFMILCAA------PWVLEVLIVKFRRRNKIERNNVDHEDVDNQGRSAMV 562
            .:...||..:||.| |..:|..|      ||:       .||:...|      |.:|.|...|.|
  Fly   605 FEAVNDYNPLFHAL-GLTLLAGASLWSFMPWI-------NRRKANAE------EQLDAQIEKAAV 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8028	NP_001097031.2	MFS	40..>215	CDD:119392	46/174 (26%)
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	140/623 (22%)
		MFS	59..>234	CDD:119392	44/174 (25%)
		MFS	<449..633	CDD:119392	41/189 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	5	4.920