DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and FARP2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011510535.1	Gene:	FARP2 / 9855	HGNCID:	16460	Length:	1061	Species:	Homo sapiens

Alignment Length:	883	Identity:	178/883 - (20%)
Similarity:	296/883 - (33%)	Gaps:	300/883 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRK--VQQLHPDLIG-----FNL 150
            |:.|.|.|  .|:.   :|:.|...:..|:.:|    .|||..||  :.:|||::.|     ...
Human   243 KIQLAVSH--MGVL---VFQGTTKINTFNWSKV----RKLSFKRKRFLIKLHPEVHGPYQDTLEF 298

  Fly   151 QLSPTERSHSDEAIYKDLHS----TDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIEN 211
            .|...:...:...|..:.|:    .|....|..::..|..||..|..||.
Human   299 LLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQ--------------- 348

  Fly   212 GTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVS--------- 267
              :.:.||.:|  |.|  ..|..:...:...|         .||.|:.||....:|
Human   349 --KQLVDYFKD--SGM--KRIPYERRHSKTHT---------SVRALTADLPKQSISFPEGLRTPA 398

  Fly   268 -------------STT--------DGASNAVTPTPESY----ARQSQSPLAAAAPSVPVSAAPGP 307
                         ||.        ..:|:::|....||    |.:.:|...|..|..|.:...||
Human   399 SPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGP 463

  Fly   308 PM---GRLVST-------SSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKV 362
            |.   |..:||       ||..|.|.:|.:            ::..:...|...:.:.|
Human   464 PALQPGPGLSTKSPQPSPSSRKSPLSLSPA------------FQVPLGPAEQGSSPLLS------ 510

  Fly   363 YEDLCYVTFQAKAKPEVTTDNIACNGTGYD-----HTNTKEEEVYQDLCALHRTSRSQTASSTSF 422
                           .|.:|   ..|.|.|     |.....:|.|
Human   511 ---------------PVLSD---AGGAGMDCEEPRHKRVPADEAY-------------------- 537

  Fly   423 EQRDYVIRELIDTESNYLDVLTALKTKFMGPL--ERHLNQDELRLIFPRIRELVDIHTKFLDKLR 485
                ::::|::.||..||..|..:...|...:  |..:....:.|:|..|..:.:.|..||.::.
Human   538 ----FIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVE 598

  Fly   486 ESL----------TPNAKVKMAQVFL-DFRE--PFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
            :.|          |..:..::..:.| :.|:  .|..|.:....:|..::.....|||
Human   599 QRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKK------- 656

  Fly   538 VQKCERDYNVGK---LQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQ 599
            ::...:::.:.|   |.|...|..|:||:|.|.|||.:|....||.|.||.....|.:|
Human   657 LEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKA------ 715

  Fly   600 YINEVKRDSDHLVI----IQKVKDSICDIHLLQNGNGSDLLQYGR-LLLDGELHIKAHEDQKTKL 659
             |.||.....|::|    :||:.:...|:..::|     |:..|| .:.:|.||....:..:.::
Human   716 -ITEVTTTLQHILIRLENLQKLTELQRDLVGIEN-----LIAPGREFIREGCLHKLTKKGLQQRM 774

  Fly   660 RYAFVFDKILIMVKALHIKTGDMQYTYRDSHNL-------ADYRVEQSHSRRTIGRDTRFKYQLL 717
            .:.| .|.:|...|.:   .|...:..|....|       .|..||:|.:..::..
Human   775 FFLF-SDMLLYTSKGV---AGTSHFRIRGLLPLQGMLLIVLDPPVEESDNEWSVPH--------- 826

  Fly   718 LARKSGKTAFTLY---------LKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTT 773
                    .||:|         ..:..|::||...|..|:::.:..|            ..||.
Human   827 --------CFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGG------------DTAPA- 870

  Fly   774 CRHCSKFLKGRIHQGYRCKVC--------QISVH-------KGCISSTGRCKQNPVSVPPPVCDR 823
                   |.||       .||        ::|:.       :|..||.....|:..:....||
Human   871 -------LPGR-------TVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVC-- 919

  Fly   824 QLSEFNWFAGNMDRETAAHR------LENRRIGTYLLR 855
                  |:     |.|:..|      :||:..| ||||
Human   920 ------WY-----RNTSVSRADHSAAVENQLSG-YLLR 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	9/38 (24%)
		RhoGEF	428..603	CDD:279015	45/192 (23%)
		PH_Vav	624..753	CDD:269930	26/145 (18%)
		PH	641..749	CDD:278594	22/123 (18%)
		C1_1	761..804	CDD:278556	9/57 (16%)
		SH2_Vav_family	824..934	CDD:198193	11/38 (29%)
		SH3	940..993	CDD:302595
FARP2	XP_011510535.1	B41	45..234	CDD:214604
		FERM_C_FARP1-like	221..341	CDD:270014	25/106 (24%)
		FA	333..375	CDD:312314	13/71 (18%)
		Herpes_ICP4_C	358..>533	CDD:332854	40/221 (18%)
		RhoGEF	537..720	CDD:238091	47/220 (21%)
		PH1_FARP1-like	749..862	CDD:269928	25/133 (19%)
		PH2_FARP1-like	935..1032	CDD:270055	7/12 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910