DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and ARHGEF2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011508441.1	Gene:	ARHGEF2 / 9181	HGNCID:	682	Length:	1139	Species:	Homo sapiens

Alignment Length:	834	Identity:	172/834 - (20%)
Similarity:	295/834 - (35%)	Gaps:	292/834 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTER 157
            :|..|.||.:.|..|               |.....|||          ...:.|.|..|   :|
Human    79 RLDQDSCHPSAGPLD---------------HSATGMLSK----------SVPVSGINCLL---DR 115

  Fly   158 SHSDEAIYKDLHSTDLNMRKTSS---------IDASASSSAEYYD------RTSQSGSLDENSDI 207
            |.:|..:.:   |:.:::||..|         :.:|...:..:..      :|.:...:.|..|.
Human   116 SDTDGNVSQ---SSAIDLRKRCSQLEGHSGTRVGSSLRQTFSFLSGMTGKAKTREKEKMKEAKDA 177

  Fly   208 TIENGTEDIDDYIEDSLSNM--------------------CDSTIDNDAEDAGVETPLLSDCQGS 252
            ...||    ..:...|:|.|                    |:.||.|..:|.      |::|  :
Human   178 RYTNG----HLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDT------LANC--T 230

  Fly   253 HVRE-------LSFDLALDVV---SSTT--DGASNAVTPTPESY------ARQSQSPLAAAAPSV 299
            .|::       |..:.||..|   |.||  :..|:|:.|: :|:      :|:.:|.| :.|.||
Human   231 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPS-DSFRQSLLGSRRGRSSL-SLAKSV 293

  Fly   300 PVSAAPG-----PPMG--RLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYS- 356
            ..:...|     .|:|  |::|.|:.|.::               .|...|:.|...|...|||
Human   294 STTNIAGHFNDESPLGLRRILSQSTDSLNM---------------RNRTLSVESLIDEAEVIYSE 343

  Fly   357 -----EDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQT 416
                 |.|||.:         |.....:..|      :.:...:.||....||
Human   344 LMSDFEMDEKDF---------AADSWSLAVD------SSFLQQHKKEVMKQQD------------ 381

  Fly   417 ASSTSFEQRDYVIRELIDTESNYLDVLTALKTKF-MGPLER-HLNQDELRLIFPRIRELVDIHTK 479
                       ||.|||.||.:::..|..:...| .|.||. ||....::.:||.:.||.||||:
Human   382 -----------VIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTR 435

  Fly   480 FLDKL----RESLTPNAKVKMAQVFLDFREPFLI---------------YGEFCSLLLGAIDYLA 525
            ||.:|    |::|.|.:    .:.|:..|...|:               |.||||....|:....
Human   436 FLSQLLERRRQALCPGS----TRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYK 496

  Fly   526 DVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERA 590
            ::..:::...|.::|..|...:.:..:::.:.:..|||.||.||:.::::.:..:.::.:.|..|
Human   497 ELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTA 561

  Fly   591 ----KEAMIDVSQYINEVKRDS-------------------------DHLVIIQKVKDSICDIHL 626
                ||.:.:|.:.|.::::.:                         :.|:..:.:.|. |.:..
Human   562 LGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDG-CLLWK 625

  Fly   627 LQNGNGSDLLQYGRLLLDGELHIKAHEDQK-----------TKLRYAFVFD-----KILIMVKA- 674
            ...|...|:|.   ||:...|.....:|||           ..|:...|.|     |.:.::.|
Human   626 TATGRFKDVLV---LLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAA 687

  Fly   675 ------LHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRD-------------TRFKYQL---- 716
                  :|..:.|.:.|:        .||.|...|....|:             .|.|.:|
Human   688 PPEMYEVHTASRDDRSTW--------IRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKD 744

  Fly   717 -----LLARKSGKTAFTLYLKSEHE-----------RDKWRKALTEAMESLEPP 754
                 ||..|.|..|...:.::|.:           |..:|.      ||||.|
Human   745 RALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRS------ESLESP 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	9/38 (24%)
		RhoGEF	428..603	CDD:279015	53/199 (27%)
		PH_Vav	624..753	CDD:269930	36/184 (20%)
		PH	641..749	CDD:278594	30/163 (18%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
ARHGEF2	XP_011508441.1	C1	183..228	CDD:237996	9/50 (18%)
		RhoGEF	379..573	CDD:238091	53/220 (24%)
		PH_ARHGEF2	613..728	CDD:275428	24/126 (19%)
		PH	616..714	CDD:278594	22/109 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910