DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and ARHGEF1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_945353.1	Gene:	ARHGEF1 / 9138	HGNCID:	681	Length:	927	Species:	Homo sapiens

Alignment Length:	949	Identity:	198/949 - (20%)
Similarity:	332/949 - (34%)	Gaps:	279/949 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AEIRILAMTLRDGVLLCNLVIHLDP-SSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDA 108
            |.::.:|:....|.|||  .:|.|. .||.|:|..              |.|||..| :|..:.|
Human    76 ALLQHVALQFEPGPLLC--CLHADMLGSLGPKEAK--------------KAFLDFYH-SFLEKTA 123

  Fly   109 DL---FEPTMLYDLTNFHRVLITLSKLSQCRKVQ---QLHPDLIGFNLQ---------LSPTERS 158
            .|   ..|.:.::|......||  |:..|.|.||   |.....:|..|:         ::|.|:.
Human   124 VLRVPVPPNVAFELDRTRADLI--SEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQE 186

  Fly   159 HS--------DEAIY--KDLHSTDL------NMRKTSSIDASASSSA--------EYYDRTSQSG 199
            .:        |.|.|  ::.|..:.      .|:.|.|.|...|::.        .:....::||
Human   187 LAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG 251

  Fly   200 SLDENSDI----TIENGTEDIDDYIEDSLSNMCDSTIDNDAE-----------DAGVETPLLSDC 249
            ......:.    .:.|...|.....:..||::.|:...|..|           :...|.|..:|.
Human   252 DKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDR 316

  Fly   250 QG-----SHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPM 309
            :|     |..|.:              ||....||....:.....||........|:......|.
Human   317 KGGVGMPSRDRNI--------------GAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQ 367

  Fly   310 GRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAK 374
            |.:     |..||...||             ....|.||....   .::.|.....|       :
Human   368 GPM-----SLESLAPPES-------------TDEGAETESPEP---GDEGEPGRSGL-------E 404

  Fly   375 AKPEVTTDNIACNGTGYDHTNTKEEEVYQDLC---ALHRTSRSQTASSTSFEQRDYVIRELIDTE 436
            .:||                   |...:::|.   .||...:||.       :|..||.||:.||
Human   405 LEPE-------------------EPPGWRELVPPDTLHSLPKSQV-------KRQEVISELLVTE 443

  Fly   437 SNYLDVLTALKTKFMGPLERHL--NQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKV--KMA 497
            :.::.:|..|...|..|:...|  ..:||:.|||.:.||:::|:.|||:|.:....:..:  ::.
Human   444 AAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIG 508

  Fly   498 QVFLD---------FREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLR 553
            .|.|.         |::   |...|||....|::.|....:|:......||:.|......:|||:
Human   509 DVLLARFDGAEGSWFQK---ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLK 570

  Fly   554 DILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVK 618
            |::...|||:.||.|||..:.:.|.. ..:...:|.|.|...::..::|:..||.:.|:.::..:
Human   571 DMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQ 634

  Fly   619 DSICDIHLLQNGN-------GSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALH 676
            ..:...||.|:.:       ..|:.: .:|:.:|.|..:..:|:..:: :..:.|.:|::::
Human   635 RRLDLSHLRQSSDPMLSEFKNLDITK-KKLVHEGPLTWRVTKDKAVEV-HVLLLDDLLLLLQ--- 694

  Fly   677 IKTGDMQYTYRDSHNLADYRVEQSHSR-----------------------RTIGRDTRFKYQLLL 718
                      |....|    :.:||||                       |.:..|.:..|.|..
Human   695 ----------RQDERL----LLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 745

  Fly   719 ARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKG 783
            ..:..: .:.|..::..||..|...:||...||:.|               ||
Human   746 WDQEAQ-IYELVAQTVSERKNWCALITETAGSLKVP---------------AP------------ 782

  Fly   784 RIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRR 848
                                :|..:.:.:|.|...|:..   |..|   ||..|||:.......|
Human   783 --------------------ASRPKPRPSPSSTREPLLS---SSEN---GNGGRETSPADARTER 821

  Fly   849 IGTYLL---RVRPQGPSTAHETMYALSLK------TDDN 878
            |.:.||   |..|:|...|......||||      .:||
Human   822 ILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDN 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	25/90 (28%)
		RhoGEF	428..603	CDD:279015	52/187 (28%)
		PH_Vav	624..753	CDD:269930	28/158 (18%)
		PH	641..749	CDD:278594	22/130 (17%)
		C1_1	761..804	CDD:278556	2/42 (5%)
		SH2_Vav_family	824..934	CDD:198193	21/64 (33%)
		SH3	940..993	CDD:302595
ARHGEF1	NP_945353.1	RGS_p115RhoGEF	67..259	CDD:188709	45/201 (22%)
		Trypan_PARP	<330..425	CDD:114603	25/141 (18%)
		RhoGEF	435..619	CDD:214619	52/187 (28%)
		PH_p115RhoGEF	653..777	CDD:275429	23/143 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910