DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and ARHGEF7

DIOPT Version :10

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_047286678.1 Gene:ARHGEF7 / 8874 HGNCID:15607 Length:874 Species:Homo sapiens


Alignment Length:709 Identity:134/709 - (18%)
Similarity:245/709 - (34%) Gaps:219/709 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ECVAWLTRCKVI-PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL-----DPREFNRKP 81
            :.|.||....|: .|....:.|:.   .|..:|:|||:||.|:..|.|.::     :||      
Human     6 QTVTWLITLGVLESPKKTISDPEG---FLQASLKDGVVLCRLLERLLPGTIEKVYPEPR------ 61

  Fly    82 QMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRV---LITLSKLSQCRKVQQLHP 143
              ::..|..||:.||..|..:..:   :.|:...||...||::|   |:||:|::          
Human    62 --SESECLSNIREFLRGCGASLRL---ETFDANDLYQGQNFNKVLSSLVTLNKVT---------- 111

  Fly   144 DLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTS-----QSGSLDE 203
                            :|..:..|......:..:..|.|:..|.|  .:.|||     |..||| 
Human   112 ----------------ADIGLGSDSVCARPSSHRIKSFDSLGSQS--LHTRTSKLFQGQYRSLD- 157

  Fly   204 NSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSS 268
                                       ..||......|....  :.|.::..||||... ||:..
Human   158 ---------------------------MTDNSNNQLVVRAKF--NFQQTNEDELSFSKG-DVIHV 192

  Fly   269 TT-------DGASNAVTP-TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVS 325
            |.       :|..|..|. .|.:|.|:      ..|...|||    |..|.|             
Human   193 TRVEEGGWWEGTLNGRTGWFPSNYVRE------VKASEKPVS----PKSGTL------------- 234

  Fly   326 ESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTG 390
                                                            |:.|:           |
Human   235 ------------------------------------------------KSPPK-----------G 240

  Fly   391 YDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLE 455
            :|                      .||.:.|:  .:.|::.:::||:.|...|..:.:.::.||:
Human   241 FD----------------------TTAINKSY--YNVVLQNILETENEYSKELQTVLSTYLRPLQ 281

  Fly   456 --RHLNQDELRLIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLDFREPF-LIYGEFCSL 516
              ..|:...:..:...:.|:.......:..|.| :..|.|:.::...||:..... .:|..:|:.
Human   282 TSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCAN 346

  Fly   517 LLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLH 581
            ...|::.|.:   .::.:.:.:: .:...:.|.|.|...||.|..|:.||..||.:|.:.....|
Human   347 HPSAVNVLTE---HSEELGEFME-TKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYH 407

  Fly   582 DDYRSLERAKEAMIDVSQYINEV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDG 645
            .|.:.::::..|..::|....|| ||....|.|:.:.         ::|..|.|:...|.:....
Human   408 TDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEA---------IRNWEGDDIKTLGNVTYMS 463

  Fly   646 ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRR 704
            ::.|:....::...||..:|..:|:|:.|....:|.:......:..:...::|.|.:.|
Human   464 QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHR 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH_VAV 19..135 CDD:409050 34/120 (28%)
RhoGEF 428..602 CDD:459876 35/177 (20%)
PH_Vav 624..753 CDD:269930 15/81 (19%)
C1_VAV 759..810 CDD:410360
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:473055
ARHGEF7XP_047286678.1 CH_betaPIX 3..115 CDD:409115 35/148 (24%)
RhoGEF67_u1 117..163 CDD:465201 14/75 (19%)
SH3_betaPIX 167..220 CDD:212994 15/61 (25%)
RhoGEF 251..428 CDD:238091 35/180 (19%)
PH_Cool_Pix 459..557 CDD:269932 11/64 (17%)
PHA03247 <564..647 CDD:223021
RhoGEF67_u2 617..719 CDD:465200
betaPIX_CC 789..873 CDD:465158
Blue background indicates that the domain is not in the aligned region.

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