DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and ARHGEF7

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001340975.1 Gene:ARHGEF7 / 8874 HGNCID:15607 Length:862 Species:Homo sapiens


Alignment Length:1061 Identity:194/1061 - (18%)
Similarity:349/1061 - (32%) Gaps:357/1061 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ECVAWLTRCKVI-PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL-----DPREFNRKP 81
            :.|.||....|: .|....:.|:.   .|..:|:|||:||.|:..|.|.::     :||      
Human     6 QTVTWLITLGVLESPKKTISDPEG---FLQASLKDGVVLCRLLERLLPGTIEKVYPEPR------ 61

  Fly    82 QMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRV---LITLSKLSQCRKVQQLHP 143
              ::..|..||:.||..|..:..:   :.|:...||...||::|   |:||:|::          
Human    62 --SESECLSNIREFLRGCGASLRL---ETFDANDLYQGQNFNKVLSSLVTLNKVT---------- 111

  Fly   144 DLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTS-----QSGSLDE 203
                            :|..:..|......:..:..|.|:..|.|  .:.|||     |..||| 
Human   112 ----------------ADIGLGSDSVCARPSSHRIKSFDSLGSQS--LHTRTSKLFQGQYRSLD- 157

  Fly   204 NSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSS 268
                                       ..||......|....  :.|.::..||||... ||:..
Human   158 ---------------------------MTDNSNNQLVVRAKF--NFQQTNEDELSFSKG-DVIHV 192

  Fly   269 TT-------DGASNAVTP-TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVS 325
            |.       :|..|..|. .|.:|.|:      ..|...|||    |..|.|             
Human   193 TRVEEGGWWEGTLNGRTGWFPSNYVRE------VKASEKPVS----PKSGTL------------- 234

  Fly   326 ESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTG 390
                                                            |:.|:           |
Human   235 ------------------------------------------------KSPPK-----------G 240

  Fly   391 YDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLE 455
            :|                      .||.:.|:  .:.|::.:::||:.|...|..:.:.::.||:
Human   241 FD----------------------TTAINKSY--YNVVLQNILETENEYSKELQTVLSTYLRPLQ 281

  Fly   456 --RHLNQDELRLIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLDFREPF-LIYGEFCSL 516
              ..|:...:..:...:.|:.......:..|.| :..|.|:.::...||:..... .:|..:|:.
Human   282 TSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCAN 346

  Fly   517 LLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLH 581
            ...|::.|.:   .::.:.:.:: .:...:.|.|.|...||.|..|:.||..||.:|.:.....|
Human   347 HPSAVNVLTE---HSEELGEFME-TKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYH 407

  Fly   582 DDYRSLERAKEAMIDVSQYINEV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDG 645
            .|.:.::::..|..::|....|| ||....|.|:.:.         ::|..|.|:...|.:....
Human   408 TDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEA---------IRNWEGDDIKTLGNVTYMS 463

  Fly   646 ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT 710
            ::.|:....::...||..:|..:|:|:.|....:|.:......:..:...::|.|.:.|.     
Human   464 QVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRN----- 523

  Fly   711 RFKYQLLLARKSGKTAFTLYLKSEHERD---------KWRKALTEAMESLEP------------- 753
              .:::     ||.....:.:...:::|         |..|..:....:::|             
Human   524 --AFEI-----SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPV 581

  Fly   754 -PGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKG--------------CI 803
             |..:..|.|      .||.|..:.:  |....|.|    ....:::.|              |:
Human   582 TPSSKHADSK------PAPLTPAYHT--LPHPSHHG----TPHTTINWGPLEPPKTPKPWSLSCL 634

  Fly   804 -------SSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGP 861
                   .|...|.:..:|..|....:.|.:........|.|.|:.:                  
Human   635 RPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRK------------------ 681

  Fly   862 STAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGL 926
            |||       :|:.|..::|.::          .||.|:    ||...|.|.::..||..|    
Human   682 STA-------ALEEDAQILKVIE----------AYCTSA----KTRQTLNSTWQGTDLMHN---- 721

  Fly   927 NQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLV---IGKDGDSKGWWRG---KIGDTVGY 985
                     .|:|.   |.:|...|  |..|:....|.   :.:|.|....|..   ::|.| ..
Human   722 ---------HVLAD---DDQPSLDS--LGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGST-SR 771

  Fly   986 FPKEYV------QEQKLASEE 1000
            ..||..      :|:|:..||
Human   772 SRKESAPQVLLPEEEKIIVEE 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 33/117 (28%)
RhoGEF 428..603 CDD:279015 35/178 (20%)
PH_Vav 624..753 CDD:269930 20/137 (15%)
PH 641..749 CDD:278594 16/116 (14%)
C1_1 761..804 CDD:278556 9/63 (14%)
SH2_Vav_family 824..934 CDD:198193 20/109 (18%)
SH3 940..993 CDD:302595 13/64 (20%)
ARHGEF7NP_001340975.1 CH 21..107 CDD:237981 26/99 (26%)
RhoGEF67_u1 117..163 CDD:318756 14/75 (19%)
SH3_betaPIX 167..220 CDD:212994 15/61 (25%)
RhoGEF 251..428 CDD:238091 35/180 (19%)
PH_Cool_Pix 459..557 CDD:269932 15/109 (14%)
Atrophin-1 <562..>643 CDD:331285 12/92 (13%)
RhoGEF67_u2 613..711 CDD:318755 22/136 (16%)
betaPIX_CC 773..859 CDD:318676 6/20 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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