DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and CDC24

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_009359.1	Gene:	CDC24 / 851190	SGDID:	S000000039	Length:	854	Species:	Saccharomyces cerevisiae

Alignment Length:	648	Identity:	129/648 - (19%)
Similarity:	241/648 - (37%)	Gaps:	179/648 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 SFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSV-------------------PVSA 303
            |.|||..:.||:...|::.::....||...:.|    |.|::                   ||:.
Yeast   100 SSDLAPTLRSSSISTATSLMSMEGISYTNSNPS----ATPNMEDTLLTFSMGILPITMDCDPVTQ 160

  Fly   304 -----APGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVY 363
                 ..|.|:..|.::......|.|..|..|:....::|::   :...:..:|:    :||:::
Yeast   161 LSQLFQQGAPLCILFNSVKPQFKLPVIASDDLKVCKKSIYDF---ILGCKKHFAF----NDEELF 218

  Fly   364 EDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRT---SRSQT--------- 416
                            |..::..|.|.   ...|..||.:.|.....|   |:|:|
Yeast   219 ----------------TISDVFANSTS---QLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAENQ 264

  Fly   417 ----ASSTSFEQRDYV--IRELIDTESNYLDVLTALKTKFMGPLERHL-NQDELRLIFPRIRELV 474
                ...:|.:..:||  |:|.:.||..|:..|..|.......|:.:| ..:||.::||.:.:.:
Yeast   265 HRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLEILDKYRQQLLDSNLITSEELYMLFPNLGDAI 329

  Fly   475 DIHTKFLDKLR-ESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV 538
            |...:||..|. .:|...:|.::..:|:..:..|.:|..:......||::|:....|.:     |
Yeast   330 DFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKMR-----V 389

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDD--YRSLERAKEAMIDVSQYI 601
            .:.:|.....||:|:..|..|:||:.:|.||:.:|:.|:|   ||  .:.||.|.:...::::.|
Yeast   390 DESQRFIINNKLELQSFLYKPVQRLCRYPLLVKELLAESS---DDNNTKELEAALDISKNIARSI 451

  Fly   602 NEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLR--YAFV 664
            ||.:|.:::..:::|:...:.      |..|..:.::|.||...::.|..........|  ..::
Yeast   452 NENQRRTENHQVVKKLYGRVV------NWKGYRISKFGELLYFDKVFISTTNSSSEPEREFEVYL 510

  Fly   665 FDKILIM------------------------VKALHI--KTGDMQYTYRDSH------------- 690
            |:||:|:                        :.|.:|  ..|...::|...|
Yeast   511 FEKIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNGSPHHSYHKRHSNSSSSNNIHLSS 575

  Fly   691 -----------NLADYRVEQSHS------------------------RRTIGRDTRFKYQLLLAR 720
                       |.:|.....|.|                        .:.|.::.|   .|.:..
Yeast   576 SSAAAIIHSSTNSSDNNSNNSSSSSLFKLSANEPKLDLRGRIMIMNLNQIIPQNNR---SLNITW 637

  Fly   721 KSGKTA--FTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFD--------APTT 773
            :|.|..  |.|..|:|..||.|...|.:.:..|:....::..|.....|..        :|||
Yeast   638 ESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKARHHSSTSTTSSTAKSSSMMSPTT 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/180 (27%)
		PH_Vav	624..753	CDD:269930	34/206 (17%)
		PH	641..749	CDD:278594	30/185 (16%)
		C1_1	761..804	CDD:278556	5/21 (24%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
CDC24	NP_009359.1	CDC24	156..242	CDD:399412	19/111 (17%)
		RhoGEF	282..453	CDD:214619	47/178 (26%)
		PH_Scd1	455..667	CDD:270066	35/220 (16%)
		PB1	779..853	CDD:214770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940