DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and LRCH3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001350816.1	Gene:	LRCH3 / 84859	HGNCID:	28637	Length:	803	Species:	Homo sapiens

Alignment Length:	173	Identity:	41/173 - (23%)
Similarity:	70/173 - (40%)	Gaps:	50/173 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASSSSSNSFGGVAGVNG----------DLWRECVAWLTRCKV-IPPDHKAAQPDAEIRILAMTLR 55
            :::.:::|...:.|.|.          |..|:.:.:  |.|| :|.|            |...|.
Human   633 SAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEY--RLKVSLPCD------------LGAALT 683

  Fly    56 DGVLLCNLVIHLDPSSL------DPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPT 114
            |||:||:|..|:.|.|:      .|    ..|::....|.:|::.||:.| ...|:...:|..|:
Human   684 DGVVLCHLANHVRPRSVPSIHVPSP----AVPKLTMAKCRRNVENFLEAC-RKIGVPQDNLCSPS 743

  Fly   115 MLYDLT-NFHRVLITLSKLSQ--------CRKVQQLHPDLIGF 148
            .:..|. :..|.:.||..|..        |..:|     |:||
Human   744 DILQLNLSVKRTVETLLSLGAHSEESSFVCLSLQ-----LLGF 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	31/119 (26%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
LRCH3	NP_001350816.1	leucine-rich repeat	61..83	CDD:275380
		LRR	<77..>285	CDD:227223
		leucine-rich repeat	84..106	CDD:275380
		leucine-rich repeat	107..129	CDD:275380
		leucine-rich repeat	130..145	CDD:275380
		leucine-rich repeat	152..174	CDD:275380
		leucine-rich repeat	175..197	CDD:275380
		leucine-rich repeat	198..218	CDD:275380
		leucine-rich repeat	220..242	CDD:275380
		leucine-rich repeat	243..261	CDD:275380
		CH	660..762	CDD:214479	32/120 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910