DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Kalrn

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_038944566.1	Gene:	Kalrn / 84009	RGDID:	621865	Length:	2989	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	152/812 - (18%)
Similarity:	279/812 - (34%)	Gaps:	267/812 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SQCRKVQQLHPDLIGFNLQLSPTERSHSDEA--IYKD-LHSTDLNMRKTSSIDASASSSAEYYDR 194
            |..||.::.|..|...:|..|...:..|...  :||: |.:::|.:  |..::......|.:..|
  Rat  1491 SLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGV--TEHVEGDPCKFALWSGR 1553

  Fly   195 TSQS---------------------------------GSLDE-------------NSDITIENGT 213
            |..|                                 |:|.|             ||.   .:|.
  Rat  1554 TPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSK---RDGV 1615

  Fly   214 EDIDDYIEDS--------LSNMCDSTIDNDAEDAGVE-TPLLSDCQGSHVRELSFDLALDV---- 265
            ||.|...:.|        .|....:|:::|....|.| |.:|.|...:|..|||..:...|
  Rat  1616 EDGDSQGDGSSQPDTISIASRTSQNTVESDKLSGGCELTVVLQDFSAAHSSELSIQVGQTVELLE 1680

  Fly   266 ---------VSSTTDGA--SNAVTPT---------------------PESYARQS-----QSPLA 293
                     :..||:.:  ...:.|:                     .:||:..|     :|...
  Rat  1681 RPSERPGWCLVRTTERSPPQEGLVPSSTLCISHSRSSVEMDCFFPLVKDSYSHSSGENGGKSESV 1745

  Fly   294 AAAPSVP----VSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAA--------AVYNYRSSM-- 344
            |...|.|    :.::|||.     .::::....|.|..:||....|        .|.:.|.|.
  Rat  1746 ANLQSQPSLNSIHSSPGPK-----RSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDL 1805

  Fly   345 ---------------ASTEHEYAYIYSEDDE----------KVYE-------------------- 364
                           |..:.:..:...|.||          |:::
  Rat  1806 GSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAPTD 1870

  Fly   365 -----DLCYVTFQAKAKPEVTTDNIACNGTGYDHT--------------NTKEEEVYQDLCALHR 410
                 || ....:...|.::|.:..:..|:..|.|              |.:||:
  Rat  1871 VPTAADL-VSAIEKLVKSKLTLEGGSYRGSLKDPTVCLNEGMAPPTPPRNLEEEQ---------- 1924

  Fly   411 TSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELR----LIFPRIR 471
                   .:.:...|.:|:.||:.||.:|:..|..:...||..:|.....:::|    ::|..|.
  Rat  1925 -------KAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIH 1982

  Fly   472 ELVDIHTK-FLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFC------SLLLGAID-YLADVC 528
            ::.|.|.. ||.:|.:.:  ..:.::||:|:.......||..:|      ..::...| |..:|
  Rat  1983 QIYDWHKDFFLAELEKCI--QEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEV- 2044

  Fly   529 KKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEA 593
              .|.|:|            :|.|.|.|..|:|||.||.|||...::.:.....:...:|:|.|.
  Rat  2045 --KQEINQ------------RLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVEL 2095

  Fly   594 MIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHI---KAHEDQ 655
            |..|.:..|:                 :.::..||...|: |...|:||.....::   .|....
  Rat  2096 MCLVPKRCND-----------------MMNLGRLQGFEGT-LTAQGKLLQQDTFYVIELDAGMQS 2142

  Fly   656 KTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR 720
            :||.|..|:|::|:|..:.|...:....|.::.|..:....:|:...      |...|:.|:
  Rat  2143 RTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEEDVD------DDPCKFALM--- 2198

  Fly   721 KSGKTAFTLYLKSEHE--RDKWRKALTEAMES 750
             :.:|:..:.|::.:.  :..|.:.:.:.:|:
  Rat  2199 -NRETSERVILQAANPDIQQAWVQDINQVLET 2229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/186 (26%)
		PH_Vav	624..753	CDD:269930	26/132 (20%)
		PH	641..749	CDD:278594	20/112 (18%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Kalrn	XP_038944566.1	SEC14	42..180	CDD:214706
		SPEC	193..413	CDD:238103
		SPEC	314..539	CDD:238103
		SPEC	540..769	CDD:238103
		SPEC	894..1132	CDD:238103
		SPEC	1138..1238	CDD:197544
		RhoGEF	1287..1457	CDD:238091
		PH1_Kalirin_Trio_like	1464..1586	CDD:270060	17/96 (18%)
		SH3_Kalirin_1	1652..1711	CDD:212786	12/58 (21%)
		SH3-RhoG_link	1708..1892	CDD:406906	27/189 (14%)
		RhoGEF	1935..2104	CDD:395496	48/185 (26%)
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061	26/132 (20%)
		SH3_Kalirin_2	2327..2385	CDD:212787
		Ig strand A	2466..2469	CDD:409353
		I-set	2474..2568	CDD:400151
		Ig strand A'	2482..2485	CDD:409353
		Ig strand B	2491..2498	CDD:409353
		Ig strand C	2504..2512	CDD:409353
		Ig strand C'	2515..2517	CDD:409353
		Ig strand D	2523..2532	CDD:409353
		Ig strand E	2534..2538	CDD:409353
		Ig strand F	2547..2555	CDD:409353
		Ig strand G	2558..2568	CDD:409353
		FN3	2572..2663	CDD:238020
		STKc_Kalirin_C	2693..2940	CDD:271017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910