DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and ATK4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_568491.1	Gene:	ATK4 / 832758	AraportID:	AT5G27000	Length:	987	Species:	Arabidopsis thaliana

Alignment Length:	770	Identity:	135/770 - (17%)
Similarity:	257/770 - (33%)	Gaps:	217/770 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECVAWLTRCKVIP--PDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLD-----PREFNRK 80
            |...||.....:.  .|......:.|.|   :.||.|::|||::..::|.|:.     |.:....
plant    49 EAAGWLRDMIGVSNGKDFPGEPSEEEFR---LGLRSGIVLCNVLNKVNPGSVSKVVEAPDDVADG 110

  Fly    81 PQMAQFLCSKNIKLFLDVCHNNFGI---RDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLH 142
            ..::.|...:||:.|| |.....|:   ..:|:.:......:.|   .::.|...|:.:...:..
plant   111 AALSAFQYFENIRNFL-VAIEEMGLPSFEASDMEKGGKSIRIVN---CILALKSYSEWKLKGENG 171

  Fly   143 PDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDI 207
            |...|.|::              .:..|..|.:||:|....|:.|..:..|..|....|..:.|.
plant   172 PWRYGSNMK--------------HNFGSRKLFLRKSSEPFVSSISRTQSTDMLSTDQPLSSDGDS 222

  Fly   208 TIENG--TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT 270
            ...||  ...|.|...:.:.|:.:|.::...|:......:.::...|..:.:..|
plant   223 RSINGLVRSFIADRKHEDIPNVVESVLNKVMEEVQQRLSIHNEMMKSSSKPIPED---------- 277

  Fly   271 DGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAA 335
            |.:...|..:....|||.:.....:.|.|...     ...|..........:|:::.:.:|....
plant   278 DSSCETVVRSQLCDARQHEEAEENSPPQVVEK-----KFQRTNFEHHEEQKILLNQQKHIQELKQ 337

  Fly   336 AVYNYRSSMASTEHEY--------------AYIYS------EDDEKVY---EDL-------CYV- 369
            .:|..::.|...:.:|              ||..:      |::.|:|   :||       |.|
plant   338 TLYTTKAGMKLLQMKYQEDFFHLGKHLNGLAYAATGYKRVLEENRKLYNLVQDLKGNIRVYCRVR 402

  Fly   370 ----------------------TFQAKAK----------------PEVTTDNI------------ 384
                                  |.:..:|                |..|.:.:
plant   403 PFLPGQESGGLSAVEDIDEGTITIRVPSKYGKAGQKPFMFNKVFGPSATQEEVFSDMQPLVRSVL 467

  Fly   385 ----AC------NGTGYDHTNTKEEEV--------YQDLCALHRTSRSQTASSTSFE-------- 423
                .|      .|:|...|.|..:|:        |:.|..|...| :|...:||:|
plant   468 DGYNVCIFAYGQTGSGKTFTMTGPKELTEESLGVNYRALADLFLLS-NQRKDTTSYEISVQMLEI 531

  Fly   424 ----QRDYVIR-------ELIDTESNYLDVLTA-----------LKTKFMGPLERHLNQDELRLI 466
                .||.:.:       |:.:...|.::|..|           ::...:|.:.|.::...:...
plant   532 YNEQVRDLLAQDGQTKRLEIRNNSHNGINVPEASLVPVSSTDDVIQLMDLGHMNRAVSSTAMNDR 596

  Fly   467 FPRIRELVDIHTKFLDKLRES----------LTPNAKVKMAQVFLD-FREPFLIYGEFCSLLLGA 520
            ..|....|.:|.:..|....|          |..:.:|..::|..| .:|     .:..:..|.|
plant   597 SSRSHSCVTVHVQGRDLTSGSILHGSMHLVDLAGSERVDKSEVTGDRLKE-----AQHINKSLSA 656

  Fly   521 IDYLADVCKKNQIIDQLVQKCER-DYNVGKLQ--LRDILSVPMQRILKYHLLLDKLVKETSPLHD 582
            :         ..:|..|.||... .|...||.  |:|.|....:.::..|     :..|...|.:
plant   657 L---------GDVISSLSQKTSHVPYRNSKLTQLLQDSLGGSAKTLMFVH-----ISPEPDTLGE 707

  Fly   583 DYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIH--LLQNGNGSDL 635
            ...:|:.| |.:..|......|.:|:..   ::::|:.|.::.  |::.|||:|:
plant   708 TISTLKFA-ERVGSVELGAARVNKDNSE---VKELKEQIANLKMALVRKGNGNDV 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	25/118 (21%)
		RhoGEF	428..603	CDD:279015	35/206 (17%)
		PH_Vav	624..753	CDD:269930	5/14 (36%)
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
ATK4	NP_568491.1	CH	46..158	CDD:278723	24/115 (21%)
		KISc_C_terminal	392..723	CDD:276817	57/351 (16%)
		KISc	394..727	CDD:214526	57/353 (16%)
		DUF4887	<841..977	CDD:292845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910