DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and si:dkey-33c9.6

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021327566.1	Gene:	si:dkey-33c9.6 / 795086	ZFINID:	ZDB-GENE-130530-592	Length:	829	Species:	Danio rerio

Alignment Length:	654	Identity:	125/654 - (19%)
Similarity:	223/654 - (34%)	Gaps:	193/654 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 EYAYIYS----EDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHR 410
            ||...|.    .:||.:..||.:..|     ||.:      :...:|...|:.        .|..
Zfish     9 EYLKAYGISPVTEDEMMDSDLLHDVF-----PEES------DWGSHDSMQTEP--------CLPS 54

  Fly   411 TSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKF------MGPLERHLNQDELRLIFPR 469
            |..|...... .::|..|::.::.:|..||..|..|.|..      .|..:..|:.::::.:|.:
Zfish    55 TPTSDNPDDL-LQKRMVVLKRVLLSEEIYLMELETLLTPMKALKASAGTSQPVLSTEQVQTVFYQ 118

  Fly   470 IRELVDIHTKFLDKLRESLTPN-------------------------AKVKMAQVFLDFREPFLI 509
            :.||.|:|.:|...|:..|.|:                         ..:.:..|||.|.....:
Zfish   119 VPELRDLHRQFYTSLQTKLHPDNVMDQGSQQSLGRDEGPVMQHYQGEHHLSVGDVFLKFVNQLGV 183

  Fly   510 YGEFCSLLLGAIDYLADVCKKNQIIDQLVQKC------------------ERDYNVGKLQLRDIL 556
            |       .|.||...:..|       :||||                  ..|....|.....:|
Zfish   184 Y-------RGFIDNYENAVK-------IVQKCMLSDQRFRILAESMMSSKSSDNVKTKYTFEALL 234

  Fly   557 SVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVII-----QK 616
            ..|:.|::|..|:|..|.|.|.|.|.|..:|:.|..........:||..:....:::.     |.
Zfish   235 YKPLDRVMKTTLVLHDLWKHTPPEHPDSITLQEALRLSSSFMSGVNERSQCKQPVMLCRGERRQL 299

  Fly   617 VKDSICDIHLLQNG-NGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK----ALH 676
            ::|... :.:.::| |...|..|..:||..:|.....:.|     |.|.:...|:.:|    |.|
Zfish   300 MRDGFV-VDVCESGHNLRHLFLYTDMLLCAKLTNAGRQAQ-----YRFCWYLPLVGLKLHWTAEH 358

  Fly   677 IKTGDMQYTYRDSHNLADYRVEQS---HSRRTIGRDTRF--------------------KYQLLL 718
            :.:.:.|.....: .:..|:::|:   |.:.:.|..:|.                    .:.|.|
Zfish   359 LPSSEYQMKISKT-RVKMYQLKQALLQHMKGSKGSVSRAVDRLRRKLEECEIWLLTNTPSFTLDL 422

  Fly   719 ARKSGKTAFTLYLKSEHERDKWRKALTE----AMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSK 779
            ...||| :.|:.|.|.::.::|:.|:.:    .:|::.|.....|...:::.....|..  ||
Zfish   423 HSTSGK-SHTVRLLSLYDLNEWKDAIEKQCGNCIETVPPDLLSVTSSCIKLRMTQQPPL--HC-- 482

  Fly   780 FLKGRIHQGYRCKVC---QISVHKG-----------CISSTG-----RCKQNPVS---VPPP--- 819
                 :......::|   .:.|...           |:...|     |.||..:|   |.|.
Zfish   483 -----VQSNESAQICGSLYVMVQSACGLQHPSSAYVCVEVDGFECYDRRKQTSLSAFCVTPQWDE 542

  Fly   820 ----VCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVI 880
                :.|.....|..|....:.:|     :|..:|..:|.:.|                  ||:.
Zfish   543 ELVFIVDGAKQLFLVFVCQYENDT-----QNDIVGRTVLNLDP------------------DNMF 584

  Fly   881 KHMK 884
            |..|
Zfish   585 KKWK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	47/223 (21%)
		PH_Vav	624..753	CDD:269930	31/160 (19%)
		PH	641..749	CDD:278594	26/138 (19%)
		C1_1	761..804	CDD:278556	6/56 (11%)
		SH2_Vav_family	824..934	CDD:198193	11/61 (18%)
		SH3	940..993	CDD:302595
si:dkey-33c9.6	XP_021327566.1	RhoGEF	71..281	CDD:214619	47/223 (21%)
		PH-like	297..453	CDD:327399	32/163 (20%)
		C2	495..605	CDD:326325	21/117 (18%)
		RhoGAP	624..812	CDD:295372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910