Protein Alignment Vav and plekhg4

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001128280.3
• Gene: plekhg4 / 779571
• XenbaseID: XB-GENE-5998210
• Length: 1921
• Species: Xenopus tropicalis
• Alignment Length: 796
• Identity: 159/796 - (19%)
• Similarity: 284/796 - (35%)
• Gaps: 218/796 - (27%)

  Fly    76 EFNRKPQMAQFLCSKNIKL--FLDVCHN----------NFGIRDADLFEPTMLYDLTNFHRVLIT 128
            :|.|:.:.:::...|::.|  |.|..:.          :|.:.|..  .|.|            .
 Frog  1080 DFWRRLEESRYQLEKSVTLYQFFDKAYEWALERMRHLASFSLDDCS--SPEM------------C 1130

  Fly   129 LSKLSQCRKVQQLHPDL----------IGFNLQLSPTER------SHSDEAIYKDLHSTDLNMRK 177
            ||.:....:.:..||::          :...|::....:      |...||.:......:..:|.
 Frog  1131 LSAIEGLERYKIQHPEISEEKFMEMKELACELKIEKATKQWKFAWSKCQEARHVLEKKLEAALRA 1195

  Fly   178 TSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSL---SNMCD---------- 229
            .|.:....||..| .|...|...|:.|.           :.|...|.   |.:|.
 Frog  1196 KSMLSGEQSSPRE-ADGMEQKELLESNR-----------NKYFFQSKPYNSPLCPRERRLGRVLC 1248

  Fly   230 --STIDNDAEDAGVETPLLSDCQGSHV------RELSF------DLALDVVSSTTDGASNAVTPT 280
              ..|.|..:....:....||. ||.|      |::|.      ||:||::.....|:|.. |.|
 Frog  1249 NRPEIGNTDDHTTRKASPTSDA-GSTVTSVFRTRKMSLQSISGEDLSLDLLHIAPSGSSTP-TVT 1311

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMG---RLVSTSSSSSSLLVSESQRLQRAAAAVYNYRS 342
            |..:.|:    |...|.|..:..:.||..|   ||              |:..:|....|:....
 Frog  1312 PRPFTRR----LLRKAQSFDLPGSEGPGYGCQRRL--------------SEPTRRGNTGVFIKGL 1358

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
            .::|||             :.:..|        .|..|.|..|             |.:|.:
 Frog  1359 EVSSTE-------------LVDRPC--------SPRQTRDWSA-------------ECMYSE--- 1386

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLER-HLNQDELR----LIF 467
             .|.|.|.:...:...:..::|.|::.||..|:..|..:...:...:|| .|.|| ||    :||
 Frog  1387 -RRCSVSSSDGRSRSSKLRHIIDEMVTTEREYVRSLWYISENYFPEMERVDLPQD-LRGKRGIIF 1449

  Fly   468 PRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEF------CSLLLGAIDYLAD 526
            ..:.:|.|.|:::..|..||.. |..::::..||..::.|.:|..:      ...|||:   ..:
 Frog  1450 GNLEKLRDFHSQYFLKELESCC-NHPLRVSHCFLRHKDQFGMYALYSKNKPRSDALLGS---HGN 1510

  Fly   527 VCKKNQIIDQLVQKCERDYNVG-KLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERA 590
            :..||           :.:.:| |:.|...|..|:||:.||.|||..|:||.....:...:..||
 Frog  1511 IFFKN-----------KQFLLGDKMDLASYLLKPIQRMSKYALLLKDLIKECEEAQEQELAYLRA 1564

  Fly   591 KEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQ 655
            .|.|:...      .|..:.|:.:..::|  ||::|.:.         |:|:...|..:..  .:
 Frog  1565 AEEMVKFQ------LRHGNDLLAMDAIRD--CDVNLKEQ---------GQLVRQDEFTVWL--GR 1610

  Fly   656 KTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR 720
            |...|:.|:|:.:::..|...|:.|...|.|:.|...||..:.::..      |:..::::...|
 Frog  1611 KKCQRHVFLFEDLILFSKPKRIEGGLDVYIYKRSFKTADIGLTENSG------DSGLRFEIWFRR 1669

  Fly   721 KSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHK-----------------MEIYTF 768
            :.......|...:...:..|...:.:.:..      |:|.:|                 ::|...
 Frog  1670 RKSSDTHILQASNPETKHAWTSDIAKILWQ------QATRNKEIRMQEMVSMGVGNKPFLDIKPS 1728

  Fly   769 DAPTTCRHCSKFLKGR 784
            ||....|.....:|||
 Frog  1729 DAAINNRAVDYIMKGR 1744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	12/70 (17%)
		RhoGEF	428..602	CDD:459876	50/185 (27%)
		PH_Vav	624..753	CDD:269930	20/128 (16%)
		C1_VAV	759..810	CDD:410360	9/43 (21%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055
plekhg4	NP_001128280.3	SEC14	726..857	CDD:469559
		SPEC	989..1193	CDD:413338	18/126 (14%)
		RhoGEF	1406..1568	CDD:459876	49/177 (28%)
		PH_puratrophin-1	1570..1705	CDD:270062	27/165 (16%)