DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and tagln

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021337144.1	Gene:	tagln / 751758	ZFINID:	ZDB-GENE-070912-1	Length:	206	Species:	Danio rerio

Alignment Length:	180	Identity:	41/180 - (22%)
Similarity:	68/180 - (37%)	Gaps:	33/180 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VAWL-TRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHL---------DPSSLDPREFNR 79
            |.|| .:|     .....:|||........|:||.:||.|:..|         ..||:   .|.:
Zfish    38 VEWLVAQC-----GSAVGRPDAGKLGFQAWLKDGCVLCELINSLSKEKPVKKIQSSSM---AFKQ 94

  Fly    80 KPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLY---DLTNFHRVLITLSKLSQCRKVQQL 141
            ..|::|||.:.          ..:|:...|:|:...|:   ||....|.|:.|..::..::....
Zfish    95 MEQVSQFLNAA----------EQYGVAKTDIFQTVDLWEGKDLAAVQRTLMALGSIAVTKEDGAF 149

  Fly   142 HPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEY 191
            ..|...|..:.....|..||:.:.:..:...|.|  .|:..||.:....|
Zfish   150 RGDPNWFFKKAQENRRDFSDDQMKEGKNVIGLQM--GSNRGASQAGMTGY 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	30/119 (25%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
tagln	XP_021337144.1	Calponin	21..193	CDD:332521	40/174 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910