DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and VAV1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_005419.2	Gene:	VAV1 / 7409	HGNCID:	12657	Length:	845	Species:	Homo sapiens

Alignment Length:	1082	Identity:	292/1082 - (26%)
Similarity:	449/1082 - (41%)	Gaps:	351/1082 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||:|..||.:|:|:||.|:.....|::..||..||||||||.|:.:|.|.:::.||.|.:|||
Human     2 ELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQM 66

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            :||||.|||:.||..|...||::.::|||...|:|:.:|.:|:.|||.||.....|  :..::.|
Human    67 SQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQ--NRGIMPF 129

  Fly   149 NLQLSPT-ERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENG 212
                 || |.|..||.||..|
Human   130 -----PTEEESVGDEDIYSGL-------------------------------------------- 145

  Fly   213 TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAV 277
            ::.|||.:|:          |.|          |.||
Human   146 SDQIDDTVEE----------DED----------LYDC---------------------------- 162

  Fly   278 TPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRS 342

Human   163 ----------------------------------------------------------------- 162

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
                .|:|.|    |.|| :||||                             .:.|.|
Human   163 ----VENEEA----EGDE-IYEDL-----------------------------MRSEPV------ 183

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRE 472
                  |.....|.:::|...:||:..||..|.|.|.:::..|:.||:|.|...::.:||..|.:
Human   184 ------SMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIED 242

  Fly   473 LVDIHTKFLDKLRESL-TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
            |:.:||.||.:::|:| ||.| ..:.|||:.::|.||:||.:||.:..|..:|..|....:.:..
Human   243 LLRVHTHFLKEMKEALGTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQM 306

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYI 601
            .:::|.:..|.|:..|||:|.|||||:|||||||.:|||.|....:. .:|..|.:||.|::|.:
Human   307 KLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEK-ENLRLALDAMRDLAQCV 370

  Fly   602 NEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFD 666
            ||||||::.|..|...:.||.::       ...|..|||..:||||.|.:.|.:....||||:.|
Human   371 NEVKRDNETLRQITNFQLSIENL-------DQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLD 428

  Fly   667 KILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT-RFKYQLLLARKSGKTAFTLY 730
            |.|::.|    :.|| .|..:|..||..::|....|.   .||. ::.:..||....|...:.|:
Human   429 KALLICK----RRGD-SYDLKDFVNLHSFQVRDDSSG---DRDNKKWSHMFLLIEDQGAQGYELF 485

  Fly   731 LKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQ 795
            .|:...:.||.:....|:.::.|....:..|..::::|:..|:|:.|...|:|..:|||||..|:
Human   486 FKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR 550

  Fly   796 ISVHKGCISSTGRC-----------------------KQNPVSV-------------PPP----- 819
            .|.||.|:.....|                       |:|.:.:             |||
Human   551 ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGP 615

  Fly   820 -----------------------------------VCDR----------QLSEFNWFAGNMDRET 839
                                               .|:|          .||...|:||.|:|..
Human   616 FLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAG 680

  Fly   840 AAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNV-IKHMKINQENSGDSMLYCLSSRRH 903
            |...|.||..||:|:|.|.:..:.     :|:|:|.  || :||:||.....    ||.::.::.
Human   681 AESILANRSDGTFLVRQRVKDAAE-----FAISIKY--NVEVKHIKIMTAEG----LYRITEKKA 734

  Fly   904 FKTIVELVSYYERNDLGENFAGLNQSLQWPYKEV-----------------IATALYDYEPKAGS 951
            |:.:.|||.:|::|.|.:.|..|:.:||:|:||.                 .|.|.||:..:..|
Human   735 FRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRS 799

  Fly   952 NQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
             :|.|:....:.::.|.| .:|||||:|...||:||..||:|
Human   800 -ELSLKEGDIIKILNKKG-QQGWWRGEIYGRVGWFPANYVEE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	53/111 (48%)
		RhoGEF	428..603	CDD:279015	67/175 (38%)
		PH_Vav	624..753	CDD:269930	36/129 (28%)
		PH	641..749	CDD:278594	32/108 (30%)
		C1_1	761..804	CDD:278556	17/42 (40%)
		SH2_Vav_family	824..934	CDD:198193	38/110 (35%)
		SH3	940..993	CDD:302595	20/52 (38%)
VAV1	NP_005419.2	CH_VAV1	2..121	CDD:409111	55/118 (47%)
		RhoGEF	195..371	CDD:238091	68/177 (38%)
		PH_Vav	385..508	CDD:269930	38/137 (28%)
		C1_VAV1	510..566	CDD:410417	18/55 (33%)
		SH3_VAV1_1	596..658	CDD:212912	5/61 (8%)
		SH2_Vav1	665..767	CDD:198268	39/112 (35%)
		SH3_VAV1_2	786..839	CDD:212909	21/54 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5144
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3961
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1723
Isobase	1	0.950	-	0	Normalized mean entropy	S4299
OMA	1	1.010	-	-		QHG52258
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm41007
orthoMCL	1	0.900	-	-		OOG6_103071
Panther	1	1.100	-	-	LDO	PTHR45818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820