Protein Alignment Vav and VAV1

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_005419.2
• Gene: VAV1 / 7409
• HGNCID: 12657
• Length: 845
• Species: Homo sapiens
• Alignment Length: 1082
• Identity: 292/1082 - (26%)
• Similarity: 449/1082 - (41%)
• Gaps: 351/1082 - (32%)

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||:|..||.:|:|:||.|:.....|::..||..||||||||.|:.:|.|.:::.||.|.:|||
Human     2 ELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQM 66

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            :||||.|||:.||..|...||::.::|||...|:|:.:|.:|:.|||.||.....|  :..::.|
Human    67 SQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQ--NRGIMPF 129

  Fly   149 NLQLSPT-ERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENG 212
                 || |.|..||.||..|
Human   130 -----PTEEESVGDEDIYSGL-------------------------------------------- 145

  Fly   213 TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAV 277
            ::.|||.:|:          |.|          |.||
Human   146 SDQIDDTVEE----------DED----------LYDC---------------------------- 162

  Fly   278 TPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRS 342
                                                                             
Human   163 ----------------------------------------------------------------- 162

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
                .|:|.|    |.|| :||||                             .:.|.|
Human   163 ----VENEEA----EGDE-IYEDL-----------------------------MRSEPV------ 183

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRE 472
                  |.....|.:::|...:||:..||..|.|.|.:::..|:.||:|.|...::.:||..|.:
Human   184 ------SMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIED 242

  Fly   473 LVDIHTKFLDKLRESL-TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
            |:.:||.||.:::|:| ||.| ..:.|||:.::|.||:||.:||.:..|..:|..|....:.:..
Human   243 LLRVHTHFLKEMKEALGTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQM 306

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYI 601
            .:::|.:..|.|:..|||:|.|||||:|||||||.:|||.|....:. .:|..|.:||.|::|.:
Human   307 KLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEK-ENLRLALDAMRDLAQCV 370

  Fly   602 NEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFD 666
            ||||||::.|..|...:.||.::       ...|..|||..:||||.|.:.|.:....||||:.|
Human   371 NEVKRDNETLRQITNFQLSIENL-------DQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLD 428

  Fly   667 KILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT-RFKYQLLLARKSGKTAFTLY 730
            |.|::.|    :.|| .|..:|..||..::|....|.   .||. ::.:..||....|...:.|:
Human   429 KALLICK----RRGD-SYDLKDFVNLHSFQVRDDSSG---DRDNKKWSHMFLLIEDQGAQGYELF 485

  Fly   731 LKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQ 795
            .|:...:.||.:....|:.::.|....:..|..::::|:..|:|:.|...|:|..:|||||..|:
Human   486 FKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCR 550

  Fly   796 ISVHKGCISSTGRC-----------------------KQNPVSV-------------PPP----- 819
            .|.||.|:.....|                       |:|.:.:             |||
Human   551 ASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGP 615

  Fly   820 -----------------------------------VCDR----------QLSEFNWFAGNMDRET 839
                                               .|:|          .||...|:||.|:|..
Human   616 FLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAG 680

  Fly   840 AAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNV-IKHMKINQENSGDSMLYCLSSRRH 903
            |...|.||..||:|:|.|.:..:.     :|:|:|.  || :||:||.....    ||.::.::.
Human   681 AESILANRSDGTFLVRQRVKDAAE-----FAISIKY--NVEVKHIKIMTAEG----LYRITEKKA 734

  Fly   904 FKTIVELVSYYERNDLGENFAGLNQSLQWPYKEV-----------------IATALYDYEPKAGS 951
            |:.:.|||.:|::|.|.:.|..|:.:||:|:||.                 .|.|.||:..:..|
Human   735 FRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRS 799

  Fly   952 NQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
             :|.|:....:.::.|.| .:|||||:|...||:||..||:|
Human   800 -ELSLKEGDIIKILNKKG-QQGWWRGEIYGRVGWFPANYVEE 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	55/115 (48%)
		RhoGEF	428..602	CDD:459876	67/174 (39%)
		PH_Vav	624..753	CDD:269930	36/129 (28%)
		C1_VAV	759..810	CDD:410360	18/73 (25%)
		SH2_Vav_family	824..934	CDD:198193	38/110 (35%)
		SH3	940..993	CDD:473055	20/52 (38%)
VAV1	NP_005419.2	CH_VAV1	2..121	CDD:409111	55/118 (47%)
		RhoGEF	195..371	CDD:238091	68/177 (38%)
		PH_Vav	385..508	CDD:269930	38/137 (28%)
		C1_VAV1	510..566	CDD:410417	18/55 (33%)
		SH3_VAV1_1	596..658	CDD:212912	5/61 (8%)
		SH2_Vav1	665..767	CDD:198268	39/112 (35%)
		SH3_VAV1_2	786..839	CDD:212909	21/54 (39%)