DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and tiam1

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_002938487.1 Gene:tiam1 / 734013 XenbaseID:XB-GENE-1006478 Length:1590 Species:Xenopus tropicalis


Alignment Length:1060 Identity:204/1060 - (19%)
Similarity:363/1060 - (34%) Gaps:360/1060 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 LYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRK--- 177
            ::.:::||.::...:..|..|:..|.        :..|.::|    .:.:..|...|.:.:|   
 Frog   655 IFSVSSFHALVAARTGESGVRRRTQA--------MSRSASKR----RSRFSSLWGLDTSSKKKQG 707

  Fly   178 TSSIDASASSSAEYYDRTSQSGSLDENSD----------ITIENGTEDIDDYIEDSL--SNMC-- 228
            .:|:....|..:|.. :.|..|..||...          .|:.....|.|.::.|.|  |.:|  
 Frog   708 RTSVTQVFSDGSESV-KKSLEGIFDETMSEEKKEKEVALSTVHPHNPDTDIWVHDYLTPSWVCLP 771

  Fly   229 -DSTI------DNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYAR 286
             |..:      |:.|:||     |...|:...:...|:.|.|..:   .|..:....|.||....
 Frog   772 NDQPVLIVIHPDDMAKDA-----LEIICKTHQLDYTSYYLRLKFL---MDNQTQIYIPKPEEEIY 828

  Fly   287 QSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHE- 350
            :.........|.                         |::..:|::...|..::..:::|.|.: 
 Frog   829 ELLYKEIEICPK-------------------------VTKHIQLEKGGGASESFGFALSSVEEDG 868

  Fly   351 --YAYIYSEDDE--------KVYEDLCYVTFQAKAKP--EVTTD---NIACNGTGY--------- 391
              :.|:.:..:.        ||.:::    .:..|||  |:.:.   ||.|..:.|         
 Frog   869 RHHLYVNNVKESGLAYKKGLKVGDEV----MEINAKPARELNSSVLKNILCKSSLYLTVRTCPDA 929

  Fly   392 ---------------------------------DHTNTKEEEVYQD--------------LCALH 409
                                             ..|..:|.||..|              :.||.
 Frog   930 GDCPLEALPRRSDTDCNDFLLLSNRDCSETDSCSETAPEEIEVQLDAPEEADSINKSTEQVAALR 994

  Fly   410 RTSRSQTASSTSFEQRDY-------------------VIRELIDTESNYLDVLTALKTKFMGPLE 455
            |:.....:..:.....::                   ||.||::||..|:..|..|..:::.||:
 Frog   995 RSPHEMNSPDSCLSPSEFAGPALATMRQLTDADKLRKVICELLETERTYVKDLNCLMERYLKPLQ 1059

  Fly   456 RH--LNQDELRLIFPRIRELVDIHTKFLDKLRES--LTPNAKVKMAQV-------------FLDF 503
            :.  |.||||.::|..:.|:|:...:||..|.:.  |.|:.: |:.:|             ||.:
 Frog  1060 KEPFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLE-KLEKVEQFKKVLFSLGGSFLYY 1123

  Fly   504 REPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNV--------GKLQ----LRDIL 556
            .:.|.:|..||:              .:..:.:::.|.:.|.|.        .|.|    |...|
 Frog  1124 ADRFKLYSAFCA--------------SHTKVPKVLVKAKTDSNFKAFLDAQNPKQQHSSTLESYL 1174

  Fly   557 SVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDS-------DHLVII 614
            ..|:||||||.|||.:|...|....:::..|:.|.:.|..|:.:|||:::..       |.|:..
 Frog  1175 IKPIQRILKYPLLLKELYSLTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEYGAVFDQLISE 1239

  Fly   615 Q--KVKDSICDIHLLQNGNGSDLLQY------------GRLLLDGELH--------IKAHED--- 654
            |  :||: :.|:.:      .|||.:            |:...|.||.        :..::|   
 Frog  1240 QSGEVKE-VADLSM------GDLLLHNTVTWLNPPASLGKWKKDPELATFVFKTAVVLVYKDSSK 1297

  Fly   655 QKTKL-----------RYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGR 708
            ||.||           |..|.| :.:|..:||.::|  |..:..:::::.:....:|.|.   ||
 Frog  1298 QKKKLGGSHRASMFEDRDPFRF-RHMIPTEALQVRT--MTTSDAETNSVCEIVHVKSESE---GR 1356

  Fly   709 DTRFKYQLLLARKSGKTAFTLYLKSEHE--RDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAP 771
            ..| .:.|..:....|..|   |::.|.  |||.|:.|.:.         :|..:..:...|...
 Frog  1357 PER-AFHLCCSNPGRKKEF---LRAVHSILRDKHRRQLLKT---------ESLPNSQQYVPFGGK 1408

  Fly   772 TTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMD 836
            ..|.     |||......|.    :|.....::...|..:|..::     |......|....:.|
 Frog  1409 RLCA-----LKGARPTMNRA----VSAPSRSLARRRRLVRNRFTI-----DSDSIFSNDPEKDSD 1459

  Fly   837 RETAAHRLENRRIGTYLLRVRPQGPSTAHET------MYALS-------------LKTDDNVIKH 882
            :||...              .||..|.:.:|      .:.|:             |.:||...:.
 Frog  1460 QETEPS--------------PPQQSSNSGDTDRWVEEQFDLAQYEEQDDVKETDILSSDDEYCES 1510

  Fly   883 MKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGEN--------------------FAGLN 927
            :|      |.||...||.:      :|..| ...|.:|..                    |:|:|
 Frog  1511 IK------GGSMEKDLSEQ------LEATS-LSSNPMGTKVQNTMNTHASRMAQLKKQTAFSGMN 1562

  Fly   928 QSLQWPYKEVIATALYDYEP 947
            .|::....|||.....|:.|
 Frog  1563 GSIESNTDEVIWVKREDFVP 1582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 2/15 (13%)
RhoGEF 428..603 CDD:279015 56/203 (28%)
PH_Vav 624..753 CDD:269930 35/164 (21%)
PH 641..749 CDD:278594 31/131 (24%)
C1_1 761..804 CDD:278556 7/42 (17%)
SH2_Vav_family 824..934 CDD:198193 26/148 (18%)
SH3 940..993 CDD:302595 2/8 (25%)
tiam1XP_002938487.1 PH1_Tiam1_2 431..557 CDD:269937
Tiam_CC_Ex 571..668 CDD:375811 2/12 (17%)
RBD 765..834 CDD:366972 16/76 (21%)
PDZ_signaling 842..924 CDD:238492 15/85 (18%)
RhoGEF 1032..1221 CDD:214619 56/203 (28%)
PH2_Tiam1_2 1223..1394 CDD:269957 41/196 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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