Protein Alignment Vav and vav2

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_031746376.1
• Gene: vav2 / 733982
• XenbaseID: XB-GENE-6067166
• Length: 914
• Species: Xenopus tropicalis
• Alignment Length: 1162
• Identity: 279/1162 - (24%)
• Similarity: 445/1162 - (38%)
• Gaps: 443/1162 - (38%)

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            ||:|..||..|||:|.||:...|.|.:..||..||||||||.|:.:|.|.|:|.::.|.:|||:|
 Frog     5 WRQCGRWLIDCKVLPVDHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQ 69

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||.|||:.||:|:.|||:|..|:|:.:|.:|:..|||:|
 Frog    70 FLCLKNIRTFLKVCHDKFGLRNCDLFDPFDLFDVRDFGKVIAALSKVS----------------- 117

  Fly   151 QLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTED 215
                                                    |::.....|.....|:.|.||
 Frog   118 ----------------------------------------YHNIAQTKGIRPFPSEDTAEN---- 138

  Fly   216 IDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
             ||.|..||..:.|
 Frog   139 -DDDIYRSLEELAD--------------------------------------------------- 151

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345
                                                                             
 Frog   152 ----------------------------------------------------------------- 151

  Fly   346 STEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHR 410
              ||:    ..|:|                     |.::.|          :|:::|:|:..:..
 Frog   152 --EHD----LGEND---------------------TYDVPC----------EEDDIYEDIIKVEN 179

  Fly   411 TS----RSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIR 471
            ..    ..|....|..::|:..:.|:.:||..|...|..:||.:|.||::.|:..|:..||..:.
 Frog   180 QQPMIRYMQKMGMTEDDKRNCCLLEIRETEDRYYRTLEDIKTYYMIPLKQILSVQEISTIFINLE 244

  Fly   472 ELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
            ||:.:|..||..:..|:...... :.|||||::|..|||||:||    .|:|      ..:.:||
 Frog   245 ELIKVHFNFLRTIELSVMSGGST-IGQVFLDYKEKLLIYGEYCS----HIEY------SQKTLDQ 298

  Fly   537 LV----------QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKET--SPLHDDYRSLER 589
            |:          ::|......||.:|:|:|.:||||:|||||||.:|:..|  ||   :.::|:.
 Frog   299 LIATREDVRTKLEECSLKVQEGKFKLQDLLVIPMQRVLKYHLLLKELLSHTADSP---ERQTLKE 360

  Fly   590 AKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHED 654
            |.:||.|::.||||||||.:.|..|.:.::||.::.:       :|.::||..:||||.:::..:
 Frog   361 ALDAMQDLAMYINEVKRDKETLKKISEFQNSIENLQV-------NLEEFGRPKIDGELKVRSMVN 418

  Fly   655 QKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDS-------HNLADYRVEQSHSRRTIGRDTRF 712
            |..:.||.|:|||::|:.|    :.|   |.|...       |.::|..:.....:::.|:  .:
 Frog   419 QAKQDRYLFLFDKVVIVCK----RRG---YNYELKEIIELLCHKMSDDPMNNKDVKKSHGK--MW 474

  Fly   713 KYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHC 777
            .|...|....||..|..:.|:|..:.||.:....||.:::|....:..|..:::|||..|.|:.|
 Frog   475 SYGFFLIHLQGKQGFQFFCKTEEMKRKWMEQFEMAMSNIKPDKANANHHNFQMFTFDKTTNCKAC 539

  Fly   778 SKFLKGRIHQGYRCKVCQISVHKGCISSTGRCK-------------------------------- 810
            ..||:|..:|||.|..|.:.|||.|:.:...||
 Frog   540 KMFLRGTFYQGYFCSRCGVGVHKECLETIHACKIGGSTDDVDSLITVSGGRTLPCRTQQKMRSAV 604

  Fly   811 -----------------------------QN---------------------------------- 812
                                         ||
 Frog   605 TNDFSGLLRNSSCNLINLKCYQGPKMVAVQNYFGNPAPPGKPVLTFQKDDVIELLRGDPNSQWWE 669

  Fly   813 ------------------PVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQ 859
                              |..|.|.|.....|::.|||||::|..|.:.|:....||||:|.||
 Frog   670 GRLLLTKKSGYFPSSSVEPCPVEPLVIRSDYSKYPWFAGNVERPQADNLLKGHVSGTYLIRERP- 733

  Fly   860 GPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFA 924
                |....:|:|:|.:|.| ||:|:.::|:    ...::..:.|::::|||.||:.:.|.|:|.
 Frog   734 ----AEAERFAISIKFNDEV-KHIKVVEKNN----WIHITEAKKFESLLELVEYYQTHSLKESFK 789

  Fly   925 GLNQSLQWPYK---------------------------------------------------EVI 938
            .|:.:|::|||                                                   ..:
 Frog   790 QLDTTLKYPYKSRTGRSSSSSSSNTPRAPASCASYNFSFLSPQGLNFPCQNPSTPFWSVFTPRPV 854

  Fly   939 ATALYDYEPKA-GSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQ 994
            .||:..|...| ...:|.||....|.:..:.|..:|||:|:....:|:||..||:|:
 Frog   855 GTAIARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	57/110 (52%)
		RhoGEF	428..603	CDD:279015	66/186 (35%)
		PH_Vav	624..753	CDD:269930	33/135 (24%)
		PH	641..749	CDD:278594	29/114 (25%)
		C1_1	761..804	CDD:278556	19/42 (45%)
		SH2_Vav_family	824..934	CDD:198193	37/109 (34%)
		SH3	940..993	CDD:302595	18/53 (34%)
vav2	XP_031746376.1	CH_VAV2	3..121	CDD:409112	60/172 (35%)
		RhoGEF	201..373	CDD:395496	65/185 (35%)
		PH_Vav	388..515	CDD:269930	35/142 (25%)
		C1_VAV2	518..575	CDD:410418	21/56 (38%)
		SH3_VAV2_1	629..688	CDD:212913	2/58 (3%)
		SH2_Vav2	699..801	CDD:198269	39/111 (35%)
		SH3_VAV2_2	855..912	CDD:212910	19/57 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5504
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1566
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm48207
Panther	1	1.100	-	-	O	PTHR45818
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190