DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and TRIO

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_009049.2	Gene:	TRIO / 7204	HGNCID:	12303	Length:	3097	Species:	Homo sapiens

Alignment Length:	686	Identity:	142/686 - (20%)
Similarity:	263/686 - (38%)	Gaps:	160/686 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSK--LSQCRKVQQLHPDLIGFNLQLSPTERS 158
            |.:.|:...:....:|.          |:..:::|.  .|....|..|.|.:||  .|.||..:.
Human  1716 LCIAHSRSSMEMEGIFN----------HKDSLSVSSNDASPPASVASLQPHMIG--AQSSPGPKR 1768

  Fly   159 HSDEAIYKDLHSTDLNMRK--TSSIDASASSSAEYY-----DRTSQSGSLDENSDITIENGTEDI 216
            ..:            .:||  ||.:...:|..|:.:     .:..:|..:.:::|.    |::..
Human  1769 PGN------------TLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSREVRKSADA----GSQKD 1817

  Fly   217 DDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNA-VTPT 280
            .|   ||.:...|.|::....:.|:.:..||....|.::....:          :|...| ..|.
Human  1818 SD---DSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEE----------EGEEGADAVPL 1869

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345
            |...|.|..|.|   .|......|....:.|..|:.:.|::.|||..:.|         .:|.||
Human  1870 PPPMAIQQHSLL---QPDSQDDKASSRLLVRPTSSETPSAAELVSAIEEL---------VKSKMA 1922

  Fly   346 STEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVT-TDN-IACNGTGYDHTNTKEEEVYQDLCAL 408
            ..:...:.:..:.|              .:.|... :|| :..:.:..|....::
Human  1923 LEDRPSSLLVDQGD--------------SSSPSFNPSDNSLLSSSSPIDEMEERK---------- 1963

  Fly   409 HRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDEL----RLIFPR 469
                      |:|.::|.||::||::||.:|:..|..:...:|..::.....|::    :::|..
Human  1964 ----------SSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGN 2018

  Fly   470 IRELVDIHTK-FLDKLRESL-TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQ 532
            |.::.|.|.. ||.:|.:.| .|.   |:..:|:.......:|          |.|..:..|...
Human  2019 IHQIYDWHRDFFLGELEKCLEDPE---KLGSLFVKHERRLHMY----------IAYCQNKPKSEH 2070

  Fly   533 IIDQLVQKCERD--YNVG-KLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAM 594
            |:.:.:.....|  ..:| :|||.|:|..|:|||:||.|||...:|.:.....|...||||.|.|
Human  2071 IVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVM 2135

  Fly   595 IDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKL 659
            ..|.:..|:                 :.::..||..:|..:.| |:|||.....:   .||...|
Human  2136 CIVPRRCND-----------------MMNVGRLQGFDGKIVAQ-GKLLLQDTFLV---TDQDAGL 2179

  Fly   660 ------RYAFVFDKILIMVKALHIKTGDMQ--YTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQL 716
                  |..|:|::|:|..:.|..|.|...  :.:::|..::...:|::     :..|   ..:.
Human  2180 LPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEEN-----VEND---PCKF 2236

  Fly   717 LLARKSGKT--AFTLYLKSEHERDKWRKALTEAMES 750
            .|..::|..  .|.|:..|...|..|...:.:.:|:
Human  2237 ALTSRTGDVVETFILHSSSPSVRQTWIHEINQILEN 2272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	5/37 (14%)
		RhoGEF	428..603	CDD:279015	50/183 (27%)
		PH_Vav	624..753	CDD:269930	30/137 (22%)
		PH	641..749	CDD:278594	24/117 (21%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786	1/1 (100%)
		SH3-RhoG_link	1715..1972	CDD:293215	60/342 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1779..1906		27/146 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1965		5/71 (7%)
		RhoGEF	1970..2143	CDD:238091	52/185 (28%)
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061	30/137 (22%)
		PH	2175..2271	CDD:278594	20/103 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2287..2552
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:254352
		Ig	2699..2776	CDD:299845
		STKc_Trio_C	2788..3050	CDD:271015
		S_TKc	2796..3050	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910