Protein Alignment Vav and TIAM1

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_003244.2
• Gene: TIAM1 / 7074
• HGNCID: 11805
• Length: 1591
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 156/731 - (21%)
• Similarity: 258/731 - (35%)
• Gaps: 257/731 - (35%)

  Fly   145 LIGFNLQL---SPTERSHSDEAIYKDLHSTDLNMRKTSSIDASAS-SSAEYYDRTSQSGSLD--- 202
            ||...:||   .|.|..:  |.:||::   ::..:.|.||....| ::|:.|..:..|...|
Human   812 LIENKMQLYVPQPEEDIY--ELLYKEI---EICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIR 871

  Fly   203 -------ENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFD 260
                   :.:.:..:.|.:..|:.:|          |:|.|.|| :.:.:|.|    .:.:.|..
Human   872 RLYVNSVKETGLASKKGLKAGDEILE----------INNRAADA-LNSSMLKD----FLSQPSLG 921

  Fly   261 LALDVVSSTTDGASNAVTP--TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLL 323
            |.:.......:|.....:|  ..:..|...:||||.      :::.||   ..|.|...||
Human   922 LLVRTYPELEEGVELLESPPHRVDGPADLGESPLAF------LTSNPG---HSLCSEQGSS---- 973

  Fly   324 VSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNG 388
                              :..|..|.|...:.|.|:.
Human   974 ------------------AETAPEETEGPDLESSDET---------------------------- 992

  Fly   389 TGYDHTNTKEEEVYQDLCALHRTSRS------------QTASSTSFEQRD---YVIRELIDTESN 438
               ||::...|:|.....:||..:.|            |.|:.......|   .||.||::||..
Human   993 ---DHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERT 1054

  Fly   439 YLDVLTALKTKFMGPLERH--LNQDELRLIFPRIRELVDIHTKFLDKLRES--LTPNAKVKMAQV 499
            |:..|..|..:::.||::.  |.||||.::|..:.|:|:...:||..|.:.  |.|:.: |:.:|
Human  1055 YVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLE-KLEKV 1118

  Fly   500 -------------FLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ-------KCERD 544
                         ||.:.:.|.:|..||:             ...::...||:       |...|
Human  1119 DQFKKVLFSLGGSFLYYADRFKLYSAFCA-------------SHTKVPKVLVKAKTDTAFKAFLD 1170

  Fly   545 YNVGKLQ----LRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVK 605
            ....|.|    |...|..|:||||||.|||.:|...|....:::..|:.|.:.|..|:.:|||::
Human  1171 AQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQ 1235

  Fly   606 RDS-------DHLVIIQK-VKDSICDIHLLQNGNGSDLLQY------------GRLLLDGELHIK 650
            :..       |.|:..|. .|..:.|:.:      .|||.:            |:...:.||
Human  1236 KIHEEFGAVFDQLIAEQTGEKKEVADLSM------GDLLLHTTVIWLNPPASLGKWKKEPEL--- 1291

  Fly   651 AHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRD----------SHNLADYR--------- 696
                      .||||...:::|             |:|          ||.|:.|.
Human  1292 ----------AAFVFKTAVVLV-------------YKDGSKQKKKLVGSHRLSIYEDWDPFRFRH 1333

  Fly   697 ----------------------VEQSHSR-RTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHE-- 736
                                  .|..|.: .:.||..|..:....:.:|.|.    :||:.|.
Human  1334 MIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKD----FLKAVHSIL 1394

  Fly   737 RDKWRKAL--TEAMES 750
            |||.|:.|  ||::.|
Human  1395 RDKHRRQLLKTESLPS 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050
		RhoGEF	428..602	CDD:459876	56/201 (28%)
		PH_Vav	624..753	CDD:269930	35/185 (19%)
		C1_VAV	759..810	CDD:410360
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055
TIAM1	NP_003244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..379
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..422
		PH1_Tiam1_2	432..558	CDD:269937
		Tiam_CC_Ex	572..669	CDD:408184
		Ubl1_cv_Nsp3_N-like	766..832	CDD:475130	7/21 (33%)
		PDZ	858..>901	CDD:214570	7/52 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..1034		26/156 (17%)
		RhoGEF	1044..1233	CDD:214619	57/202 (28%)
		PH2_Tiam1_2	1235..1406	CDD:269957	37/206 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1482