| Sequence 1: | NP_001097030.1 | Gene: | Vav / 32920 | FlyBaseID: | FBgn0040068 | Length: | 1001 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001340617.1 | Gene: | TIAM1 / 7074 | HGNCID: | 11805 | Length: | 1591 | Species: | Homo sapiens |
| Alignment Length: | 731 | Identity: | 156/731 - (21%) |
|---|---|---|---|
| Similarity: | 258/731 - (35%) | Gaps: | 257/731 - (35%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 145 LIGFNLQL---SPTERSHSDEAIYKDLHSTDLNMRKTSSIDASAS-SSAEYYDRTSQSGSLD--- 202
Fly 203 -------ENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFD 260
Fly 261 LALDVVSSTTDGASNAVTP--TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLL 323
Fly 324 VSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNG 388
Fly 389 TGYDHTNTKEEEVYQDLCALHRTSRS------------QTASSTSFEQRD---YVIRELIDTESN 438
Fly 439 YLDVLTALKTKFMGPLERH--LNQDELRLIFPRIRELVDIHTKFLDKLRES--LTPNAKVKMAQV 499
Fly 500 -------------FLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ-------KCERD 544
Fly 545 YNVGKLQ----LRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVK 605
Fly 606 RDS-------DHLVIIQK-VKDSICDIHLLQNGNGSDLLQY------------GRLLLDGELHIK 650
Fly 651 AHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRD----------SHNLADYR--------- 696
Fly 697 ----------------------VEQSHSR-RTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHE-- 736
Fly 737 RDKWRKAL--TEAMES 750 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Vav | NP_001097030.1 | CH | 20..132 | CDD:278723 | |
| RhoGEF | 428..603 | CDD:279015 | 57/202 (28%) | ||
| PH_Vav | 624..753 | CDD:269930 | 35/185 (19%) | ||
| PH | 641..749 | CDD:278594 | 30/153 (20%) | ||
| C1_1 | 761..804 | CDD:278556 | |||
| SH2_Vav_family | 824..934 | CDD:198193 | |||
| SH3 | 940..993 | CDD:302595 | |||
| TIAM1 | NP_001340617.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..78 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 298..379 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 393..422 | ||||
| PH1_Tiam1_2 | 432..558 | CDD:269937 | |||
| TIAM1_RBD | 766..841 | CDD:176413 | 9/33 (27%) | ||
| PDZ_signaling | 846..925 | CDD:238492 | 18/93 (19%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 939..1034 | 26/156 (17%) | |||
| RhoGEF | 1044..1233 | CDD:214619 | 57/202 (28%) | ||
| PH2_Tiam1_2 | 1235..1406 | CDD:269957 | 37/206 (18%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1456..1482 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||