DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Cnn2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006241100.2	Gene:	Cnn2 / 690976	RGDID:	1589807	Length:	306	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	65/289 - (22%)
Similarity:	116/289 - (40%)	Gaps:	52/289 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QPDAEIR--ILAMT-----------LRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIK 93
            |.:||:|  |..:|           |:|||:||.|:..|.|.|:.  :.||..|....|  :|:.
  Rat    29 QKEAELRSWIEGLTGLSIGPDFQKGLKDGVILCTLMNKLQPGSVP--KINRSMQNWHQL--ENLS 89

  Fly    94 LFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERS 158
            .|:... .::|:...||||...|::..|..:|.::|..|:...|.:.|... :...::.|..:..
  Rat    90 NFIKAM-VSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSG-VDIGVKYSEKQER 152

  Fly   159 HSDEAIYKDLHSTDLNMRKTSSIDASASSSAEY------YDRTSQSGSLDENSDITIENGTEDID 217
            :.|:|..| .....:.::..::..||.|....|      ||..:......::..|:::.||....
  Rat   153 NFDDATMK-AGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHCTISLQMGTNKCA 216

  Fly   218 DYI----EDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVV-------SSTTD 271
            ..:    ..:..::.|:.:..|..|....:..:...||::.....|.|...:.       .|..|
  Rat   217 SQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGSAVD 281

  Fly   272 GASNAVTPT--------PE--SYARQSQS 290
            ||     ||        ||  ||.::..|
  Rat   282 GA-----PTGGDGQGEAPEYLSYCQEEAS 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	31/102 (30%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Cnn2	XP_006241100.2	CH_CNN2	27..135	CDD:409132	33/110 (30%)
		Calponin	166..190	CDD:395325	4/23 (17%)
		Calponin	206..230	CDD:395325	3/23 (13%)
		Calponin	245..268	CDD:395325	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910