DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and SPTAN1

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001362247.1 Gene:SPTAN1 / 6709 HGNCID:11273 Length:2510 Species:Homo sapiens


Alignment Length:1139 Identity:208/1139 - (18%)
Similarity:366/1139 - (32%) Gaps:382/1139 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 LTNFHRV--LITL--SKLSQCRKVQQLHPDL------IGFNLQLSPTERSHSDEAIYKDLHSTDL 173
            |..:||.  |.||  .||....:.|....|.      |...||::      |||. |||..:...
Human    35 LDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA------SDEN-YKDPTNLQG 92

  Fly   174 NMRKTSSIDASASSSAEYYDRTSQSGS---LDENSDITIENG----------------------- 212
            .::|..:.:|...::         ||:   |||..::.|..|                       
Human    93 KLQKHQAFEAEVQAN---------SGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLE 148

  Fly   213 ---------------------TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQ---GSH 253
                                 .||:.|:|.|..:.:....:..|.|...|......:.|   .:|
Human   149 KMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAH 213

  Fly   254 ---VRELS-FDLAL-------DVVSSTTDGASNAVTPTPESYARQSQSPLAAAA----------- 296
               |.|:: |...|       :.:..|.....||.....:..|.|.|..|..||           
Human   214 EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDE 278

  Fly   297 ---------------------PSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQR----AAAA 336
                                 .||.........:.|.::........|.:|:.|||:    :|..
Human   279 TISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ 343

  Fly   337 VYNYRSSMASTEHEYAYIYSEDDEKV------------YEDLCYVTFQAKAKPEVTTDNIACNGT 389
            :...|..:.:...:...:.:|...::            :.||  .::..:.|..:..|.:|.:..
Human   344 IQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL--TSWVTEMKALINADELASDVA 406

  Fly   390 GYD-----HTNTKEE-EVYQD------------LCALHRT-----------SRSQTASSTSFEQR 425
            |.:     |...|.| :.::|            |.|.|..           |..:.|....:|.|
Human   407 GAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELR 471

  Fly   426 DYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTP 490
            .....:.:|.:..|.|  |.....:|...|..|..::|......:..|:..|..|    .:||: 
Human   472 RQQYEQCMDLQLFYRD--TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLS- 529

  Fly   491 NAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDY-LADVC--------KKNQIIDQLVQKCERDYN 546
                  ||     .|......||.:.|:....| :.||.        ::|.:.::.:::      
Human   530 ------AQ-----EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRR------ 577

  Fly   547 VGKLQLRDILSVPMQRIL------------KYHLLLDKLVKETSPL------HDDYR-------- 585
              :.||.|  |..:|:..            |.....|:..|:.|.|      |..:.        
Human   578 --RAQLAD--SFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQS 638

  Fly   586 ---SLERAKEAMIDVSQYI-NEVKRDSDHLVII---------------------QKVKDSICDI- 624
               :||:|.:.:|||:.|. :||....:.::.:                     |:...::.|| 
Human   639 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIE 703

  Fly   625 --------HLLQNGNGSDL-----LQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK--- 673
                    ||..:..|.||     ||....||:.:  :.||:|:         .|.|.|..:   
Human   704 LWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD--VAAHQDR---------IDGITIQARQFQ 757

  Fly   674 -ALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYL----KS 733
             |.|.          |:.|:      :......:.|....| :.::|||. |.|.:|.|    :.
Human   758 DAGHF----------DAENI------KKKQEALVARYEALK-EPMVARKQ-KLADSLRLQQLFRD 804

  Fly   734 EHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISV 798
            ..:.:.|.:.        :.|...||:...::.         .....||.  ||..:   .:|:.
Human   805 VEDEETWIRE--------KEPIAASTNRGKDLI---------GVQNLLKK--HQALQ---AEIAG 847

  Fly   799 HKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPST 863
            |:..|.:..: |.|           .:.|...||.. |.:...|.|..:  ...|.....|....
Human   848 HEPRIKAVTQ-KGN-----------AMVEEGHFAAE-DVKAKLHELNQK--WEALKAKASQRRQD 897

  Fly   864 AHETMYALSLKTDDNVIKH-MKINQ-----------ENSGDSMLYCLSSRRHFKTIVELVSYYER 916
            ..:::.|.....|.|..:. |:..:           |:|.:::|     ::|...:.:|.:|   
Human   898 LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALL-----KKHEALMSDLSAY--- 954

  Fly   917 NDLGENFAGLNQSLQWPYKEVIAT----------ALYDYEPKAGSNQLQLRTDCQVLVIGKDGDS 971
               |.:...|.:..|...::|..|          |||||:.|:.......:.|...|:   :..:
Human   955 ---GSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLL---NSTN 1013

  Fly   972 KGWWRGKIGDTVGYFPKEYVQE----QKLASEEL 1001
            |.||:.::.|..|:.|..||::    |..:.|.|
Human  1014 KDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 6/16 (38%)
RhoGEF 428..603 CDD:279015 41/213 (19%)
PH_Vav 624..753 CDD:269930 30/150 (20%)
PH 641..749 CDD:278594 22/115 (19%)
C1_1 761..804 CDD:278556 6/42 (14%)
SH2_Vav_family 824..934 CDD:198193 21/121 (17%)
SH3 940..993 CDD:302595 17/62 (27%)
SPTAN1NP_001362247.1 Spectrin 56..158 CDD:334073 20/117 (17%)
SPEC 162..373 CDD:238103 34/210 (16%)
SPEC 374..584 CDD:238103 43/239 (18%)
SPEC 480..690 CDD:238103 43/237 (18%)
SPEC 691..902 CDD:238103 52/276 (19%)
Spectrin 902..>983 CDD:334073 15/91 (16%)
SH3_Alpha_Spectrin 983..1035 CDD:212742 16/54 (30%)
SPEC 1104..1351 CDD:238103
SPEC 1246..1457 CDD:238103
SPEC 1458..1675 CDD:238103
Spectrin 1675..1777 CDD:334073
SPEC 1782..1991 CDD:238103
SPEC 1888..2099 CDD:238103
SPEC 1995..2213 CDD:238103
SPEC 2113..2350 CDD:238103
EFh 2365..2433 CDD:238008
EFhand_Ca_insen 2440..2508 CDD:312305
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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