DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and SOS2

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_008870.2 Gene:SOS2 / 6655 HGNCID:11188 Length:1332 Species:Homo sapiens


Alignment Length:688 Identity:131/688 - (19%)
Similarity:225/688 - (32%) Gaps:247/688 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 LSQCRKVQ-QLHPDLIGFNLQLSPTERS--HSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYD 193
            :|..|||| |:||       .||..|.|  :.:|.|::.|:...:...:|               
Human    24 VSALRKVQEQVHP-------TLSANEESLYYIEELIFQLLNKLCMAQPRT--------------- 66

  Fly   194 RTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELS 258
                               .:|:::.::.:..:..|.....||:.| :|                
Human    67 -------------------VQDVEERVQKTFPHPIDKWAIADAQSA-IE---------------- 95

  Fly   259 FDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLL 323
                                      .|:.::||......:..|..  ..:|..|....|...:.
Human    96 --------------------------KRKRRNPLLLPVDKIHPSLK--EVLGYKVDYHVSLYIVA 132

  Fly   324 VSE---SQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDD-------EKVYEDLCYVTFQAKAKPE 378
            |.|   :..|:.|...|:|.|.          |..|:.|       :||..|:            
Human   133 VLEYISADILKLAGNYVFNIRH----------YEISQQDIKVSMCADKVLMDM------------ 175

  Fly   379 VTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVL 443
            ...|:|.......|..::..|..|.||.      |::.|     |:|.| :|||     |.  ::
Human   176 FDQDDIGLVSLCEDEPSSSGELNYYDLV------RTEIA-----EERQY-LREL-----NM--II 221

  Fly   444 TALKTKFMGPLERHL-NQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPF 507
            ...:..|:.  :|.| ...::..||..|.::.::..|.|..:.::      |:|.    |...|.
Human   222 KVFREAFLS--DRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDT------VEMT----DESSPH 274

  Fly   508 LIYGEFCSLLLGAIDYLADVCKKN-----QIIDQLVQKCERDYNVGKLQLRD------------- 554
            .:.|. |         ..|:.::.     :.:.|.:...|...:..||..|.             
Human   275 PLAGS-C---------FEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGF 329

  Fly   555 ----------ILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRD-- 607
                      ::.||:.....|..|| |.:|..|...:|...|.:|..|::::...::.:.:.  
Human   330 KEAVRYVLPRLMLVPVYHCWHYFELL-KQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYS 393

  Fly   608 ------------------SDHLVI-----IQKVKDSICDIHLLQNGNGSDLLQ-YGRLLLDGEL- 647
                              |.||.|     |||..|         ...|.|:.| ....:::|.| 
Human   394 PRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNID---------GWEGKDIGQCCNEFIMEGPLT 449

  Fly   648 HIKA-HEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTI----G 707
            .|.| ||      |:.|:||.::|..|..|      ..|....::.|:||:::....|.|    .
Human   450 RIGAKHE------RHIFLFDGLMISCKPNH------GQTRLPGYSSAEYRLKEKFVMRKIQICDK 502

  Fly   708 RDT-RFKYQLLLARKSGKTAFTLYLKSEHERDKWRKAL 744
            .|| ..|:...|..|. :.:.....||..|::.|..||
Human   503 EDTCEHKHAFELVSKD-ENSIIFAAKSAEEKNNWMAAL 539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 131/688 (19%)
RhoGEF 428..603 CDD:279015 36/203 (18%)
PH_Vav 624..753 CDD:269930 33/129 (26%)
PH 641..749 CDD:278594 30/111 (27%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
SOS2NP_008870.2 Histone 63..169 CDD:329110 24/194 (12%)
RhoGEF 199..386 CDD:238091 44/228 (19%)
PH_SOS 437..543 CDD:269963 31/116 (27%)
RasGEFN 595..739 CDD:214571
RasGEF 774..1013 CDD:238087
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1061
NupH_GANP <1023..>1142 CDD:318883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1076..1096
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1142..1332
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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