DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and Sptan1

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_008759895.1 Gene:Sptan1 / 64159 RGDID:621714 Length:2498 Species:Rattus norvegicus


Alignment Length:1138 Identity:202/1138 - (17%)
Similarity:357/1138 - (31%) Gaps:380/1138 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 LTNFHRV--LITL--SKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTS 179
            |..:||.  |.||  .||....:.|....|.......:....:..|||. |||..:....::|..
  Rat    23 LDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDEN-YKDPTNLQGKLQKHQ 86

  Fly   180 SIDASASSSAEYYDRTSQSGS---LDENSDITIENG----------------------------- 212
            :.:|...::         ||:   |||..::.|..|                             
  Rat    87 AFEAEVQAN---------SGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142

  Fly   213 ---------------TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQ---GSH---VRE 256
                           .||:.|:|.|..:.:....:..|.|...|......:.|   .:|   |.|
  Rat   143 IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNE 207

  Fly   257 LS-FDLAL-------DVVSSTTDGASNAVTPTPESYARQSQSPLAAAA----------------- 296
            :: |...|       :.:..|.....||.....:..|.|.|..|..||                 
  Rat   208 VNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIK 272

  Fly   297 ---------------PSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQR----AAAAVYNYRS 342
                           .||.........:.|.::........|.:|:.|||:    :|..:...|.
  Rat   273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSANQIQVKRE 337

  Fly   343 SMASTEHEYAYIYSEDDEKV------------YEDLCYVTFQAKAKPEVTTDNIACNGTGYD--- 392
            .:.:...:...:.:|...::            :.||  .::..:.|..:..|.:|.:..|.:   
  Rat   338 ELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDL--TSWVTEMKALINADELANDVAGAEALL 400

  Fly   393 --HTNTKEE-EVYQD------------LCALHRT-----------SRSQTASSTSFEQRDYVIRE 431
              |...|.| :.::|            |.|.|..           |..:.|....:|.|.....:
  Rat   401 DRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLSILSEERAALLELWELRRQQYEQ 465

  Fly   432 LIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKM 496
            .:|.:..|.|  |.....:|...|..|..::|......:..|:..|..|    .:||:       
  Rat   466 CMDLQLFYRD--TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLS------- 517

  Fly   497 AQVFLDFREPFLIYGEFCSLLLGAIDY-LADVC--------KKNQIIDQLVQKCERDYNVGKLQL 552
            ||     .|......||.:.|:....| :.||.        ::|.:.::.:.:        :.||
  Rat   518 AQ-----EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHR--------RAQL 569

  Fly   553 RDILSVPMQRIL------------KYHLLLDKLVKETSPL------HDDYR-----------SLE 588
            .|  |..:|:..            |.....|:..|:.|.|      |..:.           :||
  Rat   570 AD--SFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALE 632

  Fly   589 RAKEAMIDVSQY--------INEV-----------------KRDSDHLVIIQKVKDSICDI---- 624
            :|.:.:|||:.|        :|||                 .|:::..   |:...::.||    
  Rat   633 KAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQ---QQFNRNVEDIELWL 694

  Fly   625 -----HLLQNGNGSDL-----LQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK----AL 675
                 ||..:..|.||     ||....||:.:  :.||:|:         .|.|.|..:    |.
  Rat   695 YEVEGHLASDDYGKDLTNVQNLQKKHALLEAD--VAAHQDR---------IDGITIQARQFQDAG 748

  Fly   676 HIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYL----KSEHE 736
            |.          |:.|:      :......:.|....| :.::|||. |.|.:|.|    :...:
  Rat   749 HF----------DAENI------KKKQEALVARYEALK-EPMVARKQ-KLADSLRLQQLFRDVED 795

  Fly   737 RDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKG 801
            .:.|.:.        :.|...||:...::.         .....||.  ||..:.::........
  Rat   796 EETWIRE--------KEPIAASTNRGKDLI---------GVQNLLKK--HQALQAEIAGHEPRIK 841

  Fly   802 CISSTGRCKQNPVSVPPPVCDRQLSEFN--WFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTA 864
            .::..|................:|||.|  |       |....:...||             ...
  Rat   842 AVTQKGNAMVEEGHFAAEDVKAKLSELNQKW-------EALKAKASQRR-------------QDL 886

  Fly   865 HETMYALSLKTDDNVIKH-MKINQ-----------ENSGDSMLYCLSSRRHFKTIVELVSYYERN 917
            .:::.|.....|.|..:. |:..:           |:|.:::|     ::|...:.:|.:|    
  Rat   887 EDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALL-----KKHEALMSDLSAY---- 942

  Fly   918 DLGENFAGLNQSLQWPYKEV----------IATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSK 972
              |.:...|.:..|...::|          :..|||||:.|:.......:.|...|:   :..:|
  Rat   943 --GSSIQALREQAQSCRQQVAPMDDETGKELVLALYDYQEKSPREVTMKKGDILTLL---NSTNK 1002

  Fly   973 GWWRGKIGDTVGYFPKEYVQE----QKLASEEL 1001
            .||:.::.|..|:.|..||::    |..:.|.|
  Rat  1003 DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 6/16 (38%)
RhoGEF 428..603 CDD:279015 41/220 (19%)
PH_Vav 624..753 CDD:269930 30/150 (20%)
PH 641..749 CDD:278594 22/115 (19%)
C1_1 761..804 CDD:278556 4/42 (10%)
SH2_Vav_family 824..934 CDD:198193 21/123 (17%)
SH3 940..993 CDD:302595 16/52 (31%)
Sptan1XP_008759895.1 Spectrin 44..147 CDD:278843 17/112 (15%)
SPEC 150..361 CDD:238103 34/210 (16%)
SPEC 362..572 CDD:238103 43/239 (18%)
SPEC 468..678 CDD:238103 45/237 (19%)
SPEC 679..890 CDD:238103 48/281 (17%)
Spectrin 890..>958 CDD:278843 13/78 (17%)
SH3_Alpha_Spectrin 971..1023 CDD:212742 16/54 (30%)
SPEC 1092..1339 CDD:238103
SPEC 1234..1445 CDD:238103
SPEC 1446..1663 CDD:238103
Spectrin 1663..1767 CDD:278843
SPEC 1770..1979 CDD:238103
SPEC 1876..2087 CDD:238103
SPEC 1983..2201 CDD:238103
SPEC 2101..2338 CDD:238103
EFh 2353..2421 CDD:238008
EF-hand_7 2356..2421 CDD:290234
EFhand_Ca_insen 2428..2496 CDD:285885
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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