DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and arhgef3.1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001027503.1	Gene:	arhgef3.1 / 613095	XenbaseID:	XB-GENE-5940983	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	403	Identity:	87/403 - (21%)
Similarity:	158/403 - (39%)	Gaps:	77/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 ALHRTSR--SQTASSTSFE------QRDYVIRELIDTESNYLDVLTALKTKFMGPLER--HLNQD 461
            |..|:|:  .:|..|...|      :|..||.||:..|...::.|..::..:..|:.:  .|:::
Frog   134 AKRRSSKLWRETFDSAGEELSAREIKRQEVIFELMQGEHTLIEDLNLVRKNYYEPMLKLEILSRE 198

  Fly   462 ELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLI--------YGEFCSLLL 518
            ||..||..:..|..:|...|::|       .|:::....|:...|.::        |..:|...:
Frog   199 ELEQIFGILDSLAPLHQDLLERL-------LKLRLEDGTLEVIGPTMLEWLPCLHAYKTYCCNQV 256

  Fly   519 GAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDD 583
            .| ..|.|..::...:...::.|:......||.:...|.:|..|::||.|||.:|:|.|.|.|.|
Frog   257 AA-KSLLDHKRRCAAVQNFLRLCQESAFSRKLDVWSFLDLPRSRLVKYPLLLKELLKHTGPEHPD 320

  Fly   584 YRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIH-----LLQNGNGSDLLQYGRLL- 642
            |..|..|...:..:...||            .|..::.|:.:     .|........:...|||
Frog   321 YTPLGEAVCMIQTIVSLIN------------SKTGEAECEYYRRRLTYLYESQEEGAVTSSRLLH 373

  Fly   643 LDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQY-TYRDS--------HNLADYRVE 698
            ..|||  |.::.|:.::   |:|:..|::.:.: .:...:|: .||..        .:|.|..|.
Frog   374 CHGEL--KNNKGQRLQV---FLFEAALVLTRPI-TQNHQLQFQVYRQPIPLQELVLEDLPDGEVR 432

  Fly   699 QSHSRR-----TIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMES-------- 750
            ...|.|     ...|...| :::....:|...:.||.......:.:|...:.:|..:
Frog   433 VGGSIRGAFTPATERAKNF-FRVSFQDRSRGQSHTLQANDSFNKQQWVSCIRQAKAANQRGSTSP 496

  Fly   751 ---LEPPGCQSTD 760
               .||| |...|
Frog   497 GGPPEPP-CTLVD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	45/184 (24%)
		PH_Vav	624..753	CDD:269930	27/159 (17%)
		PH	641..749	CDD:278594	25/122 (20%)
		C1_1	761..804	CDD:278556	87/403 (22%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
arhgef3.1	NP_001027503.1	RhoGEF	163..339	CDD:214619	44/183 (24%)
arhgef3.1	NP_001027503.1	PH_RhoGEF3_XPLN	353..486	CDD:269976	26/139 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910