Protein Alignment Vav and PLEKHG1

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001316727.1
• Gene: PLEKHG1 / 57480
• HGNCID: 20884
• Length: 1444
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 136/551 - (24%)
• Similarity: 237/551 - (43%)
• Gaps: 126/551 - (22%)

  Fly   268 STTDG------ASNAVT--PTPESYAR----QSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSS 320
            |.|||      ..:|||  |.|::.||    |....:..:....|||..         |||||:|
Human    24 SITDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFG---------STSSSAS 79

  Fly   321 SLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIA 385
            |          |.:...:..|.::.|..|  ..::::|.|.....|..:..:..:..|:..||.|
Human    80 S----------RDSHGSFGSRMTLVSNSH--MGLFNQDKEVGAIKLELIPARPFSSSELQRDNPA 132

  Fly   386 CNGTGYDHTNTKEEEVYQDLCALHRTSRSQ--------------TASSTSFEQRDYVIRELIDTE 436
               ||..:.:...|          |..|:|              :|:|......|.|::|:::||
Human   133 ---TGQQNADEGSE----------RPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETE 184

  Fly   437 SNYLDVLTALKTKFMGPLERH----LNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMA 497
            ..|:..|.::...::..:...    |..:|...:|..|:::...:::.|..|..  ..|..|.:|
Human   185 RTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLEN--CENDPVAIA 247

  Fly   498 QVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNV-GKLQLRDILSVPMQ 561
            :.|:...|.|.||.::|:....::..|.: |.:|:|:.:..:  ||...: ..|.|...|..|:|
Human   248 ECFVSKSEEFHIYTQYCTNYPRSVAVLTE-CMRNKILAKFFR--ERQETLKHSLPLGSYLLKPVQ 309

  Fly   562 RILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHL 626
            |||||||||.::........:.|..:..|.:.|..|:.:||::||..:|.|.:|:::.      |
Human   310 RILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQS------L 368

  Fly   627 LQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHN 691
            |.|..|.||..||.|:|:|...|:..::::|    .|:|||:|::.     |..|..:||: :|.
Human   369 LTNWKGPDLTSYGELVLEGTFRIQRAKNERT----LFLFDKLLLIT-----KKRDDTFTYK-AHI 423

  Fly   692 LAD--YRVEQSHSRRTIGRD----TRFKYQLLLARKSGKTAFTLYLKSEHERDKW---------- 740
            |..  ..||      .|.::    :.|.|      |:.|...|:..||:.::..|
Human   424 LCGNLMLVE------VIPKEPLSFSVFHY------KNPKLQHTVQAKSQQDKRLWVLHLKRLILE 476

  Fly   741 ----------RKALTEAMESLEPPG-CQSTD 760
                      ::|:.| |:::..|| |.|.:
Human   477 NHAAKIPAKAKQAILE-MDAIHHPGFCYSPE 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050
		RhoGEF	428..602	CDD:459876	45/178 (25%)
		PH_Vav	624..753	CDD:269930	38/154 (25%)
		C1_VAV	759..810	CDD:410360	0/2 (0%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055
PLEKHG1	NP_001316727.1	RhoGEF	176..350	CDD:459876	45/178 (25%)
		PH_PLEKHG1_G2_G3	332..477	CDD:270063	46/172 (27%)