DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and RhoGAP1A

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster

Alignment Length:	868	Identity:	178/868 - (20%)
Similarity:	311/868 - (35%)	Gaps:	270/868 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IPPDHKAAQPDAEIRIL-AMTLRDGVLLC------NLVIHLDPS---------SLDPR-EFNRK- 80
            ||....::.|..|..:: .|.......||      :|..::.||         :||.: ...||
  Fly   319 IPSQQLSSSPKRETYMINTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKT 383

  Fly    81 -PQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKV------ 138
             |::::|:...|.:|..::....  :..||..|.|...|           |..|.|..:
  Fly   384 TPELSKFVNVNNPELMEELGRKM--VSKADSLEQTRRND-----------SSPSGCGSLGRTSST 435

  Fly   139 --QQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSL 201
              :.|.|...|  :..|||.                 ::.||..:..:.|||....:|.|...::
  Fly   436 PGRSLTPGRTG--VGASPTG-----------------SLSKTGKLAMADSSSTSSLERRSCLQAV 481

  Fly   202 DENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQG-SHVRELSFDLALDV 265
            |  :||    |||.     .:|.:|.         ...|.:..|.|  || |.|:..|:    :.
  Fly   482 D--ADI----GTES-----RESGANQ---------RSVGSKESLTS--QGISEVQIKSY----ES 520

  Fly   266 VSSTTDGASNAVTPTPESYARQSQS---PLAAAAP---SVPVSAAPGPPM----GRLVSTSS--- 317
            |||.:..::.||.      ::||.:   .||...|   |||:....|..:    ||..|:||
  Fly   521 VSSLSSESAKAVA------SQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDD 579

  Fly   318 ---SSSSLLVSESQRLQRAAAAVYNY-------------RSSMASTEHEY-----AYIYSEDDEK 361
               ..||:|...:.....:.....||             |||...::.||     ....|.||:
  Fly   580 LSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDDQ- 643

  Fly   362 VYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDL------CALHRTSRSQTASST 420
                              ||            |.|....:.::|      |...|.::.::
  Fly   644 ------------------TT------------TQTTPGAIRKNLVSAILVCGNARGAKIRS---- 674

  Fly   421 SFEQRDYVIRELIDTESNYLDVLTAL---KTKFMGPL---ERHLNQDELRLIFPRIRELVDIHTK 479
                   ::..:|.:|:.|::.|..:   |......|   :..:.::|...||.:|.||.|:||.
  Fly   675 -------ILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTG 732

  Fly   480 FLDKLRESLT-PNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKN-----QIIDQLV 538
            ||..|:..:: ....|.:.:.|....|.|.:|..|......||:.:.. |..|     :|:..:|
  Fly   733 FLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKK-CSANNPQFKKIVSTIV 796

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE 603
            ...:.:.:   |.|.|:|..|:.|:....|:.:.|::||...|.|::.|.:|::.   :..::|:
  Fly   797 LNLQTEQS---LTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKI---IQMFLNQ 855

  Fly   604 VKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRL--LLDGELHIKAHEDQKTKLRYAFVFD 666
            ..      |:.|:       :.:..|.|...:::...:  |:||.          .|||:.|:|:
  Fly   856 FN------VVNQR-------LPIESNRNLRRMVRNSFIVELVDGH----------RKLRHLFLFN 897

  Fly   667 KILIMVKALHIKTGDMQYTYR--------DSHNLADYRVEQSHSR----RTIGRDTRF------- 712
            .::...|...:....:.|..:        ..:..||..||...|.    ..:.|:.|.
  Fly   898 DVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAM 962

  Fly   713 --------------KY---------QLLLA---------RKSGKTAFTLYLKSEHERDKWRKALT 745
                          ||         ||:||         .|:.....|.:|.|:.||.:|..::.
  Fly   963 EVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSIL 1027

  Fly   746 EAMESLEPPGCQSTDHKMEIYTF 768
            ...:....||. :|.:.:|:..|
  Fly  1028 SLKQKCNLPGA-NTINSLEVTAF 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	24/116 (21%)
		RhoGEF	428..603	CDD:279015	44/186 (24%)
		PH_Vav	624..753	CDD:269930	32/181 (18%)
		PH	641..749	CDD:278594	30/160 (19%)
		C1_1	761..804	CDD:278556	2/8 (25%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	45/188 (24%)
		PH_BCR_arthropod	851..1037	CDD:270174	35/208 (17%)
		C2	1079..1187	CDD:301316
		RhoGAP	1203..1398	CDD:295372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910