DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and mcf2lb

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009303050.1	Gene:	mcf2lb / 569231	ZFINID:	ZDB-GENE-081104-416	Length:	1097	Species:	Danio rerio

Alignment Length:	790	Identity:	171/790 - (21%)
Similarity:	285/790 - (36%)	Gaps:	239/790 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 RDAD-LFEPTMLYDLTNFHRVLITL---------------SKLSQCRKV-------QQLHPDL-- 145
            ||.| ...|..|.:|...||:|..|               :||..|.||       |||..:|
Zfish   278 RDPDSSLNPDQLENLATVHRLLSQLNESSTAFDEFWIQHQNKLELCLKVCQFEHNFQQLRTELDR 342

  Fly   146 ----------IGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGS 200
                      :|    :||.:..|    :.::|  |:...:....:|...|..||.......|..
Zfish   343 ATETLNAFSAVG----ISPAQTEH----LLQEL--TNHEKKVCEVLDRVRSLVAEGQGLIDSSQI 397

  Fly   201 LDEN-----SDI--TIENGTEDIDD--------------------YIEDSLSNMCDSTIDNDAED 238
            ||::     |::  ..||.|:::.|                    :.:|.:..:....:|.....
Zfish   398 LDDSIAAKCSELEKASENLTQELKDKQTKLTQAMDLHKRLDMMCKWCDDGIYMLASQPLDKCQSQ 462

  Fly   239 AGVETPLLS-DCQGSHVRELSFDLALDVVSSTTDGASN-----AVTPTPESYA---------RQS 288
            .|.|:.|.. :|......|.. ...:..|....|...|     .||...|..|         |.|
Zfish   463 EGAESALSELECYLETANEKQ-KWEISTVWQEYDNILNNELREQVTRAFEKKASLQEMFDRRRVS 526

  Fly   289 QSPLAA--AAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEY 351
            ...|||  ..|..||  ||.|            .||                   ||.|..:||.
Zfish   527 LKKLAAKQTRPVQPV--APSP------------ESL-------------------SSPAHRDHES 558

  Fly   352 AYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQT 416
            ..| |||.:.          :...| ::.:|.:..:..   :.:..|||  :.|..|.|
Zfish   559 ICI-SEDSDS----------RGSCK-QINSDQVDRSSR---NASVSEEE--ETLAVLRR------ 600

  Fly   417 ASSTSFEQRDYVIRELIDTESNYLDVLTALKTKF--------MGPLERHLNQDELRLIFPRIREL 473
                      :|:.||::||..|::.|..:...:        |.||.....|::..::|..::|:
Zfish   601 ----------HVMNELLETERAYVEELMCVLQGYAAEMDNPSMAPLIPAALQNKKDVLFGNMQEI 655

  Fly   474 VDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFC-------SLLLGAIDYLADVCKKN 531
            .:.|.:...:..|:.|...:: :.:.|||:.....||.::|       ||.....|     |
Zfish   656 YNFHKRIFLRELETYTDYPEL-VGRCFLDWMGELQIYEKYCHNKPRSESLWRQCSD-----C--- 711

  Fly   532 QIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMID 596
                ...|:|::... .||.|...|..|:|||.||.||:.:::|.:....... .|:.|..:::.
Zfish   712 ----AFFQECQKKLE-HKLGLDSYLLKPVQRITKYQLLIKEMIKYSKGCEGSV-ELQAALSSILG 770

  Fly   597 VSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGEL---------HIKAH 652
            :.:.:|    ||.||:.|..           .:||..||   ||||:.|..         |:|..
Zfish   771 ILKAVN----DSMHLIAITG-----------YDGNLGDL---GRLLMQGSFSVWAEHKRGHVKVM 817

  Fly   653 EDQKTK--LRYAFVFDKILIMVKALHIKTGD-----MQYTYRDSHNLADYRVEQSHSRRTIGRDT 710
            |..:.|  .|:.|:.:|.|:..|... ::|:     ..|:::...::|...:.: |::   |...
Zfish   818 ELARFKPMQRHLFLHEKALLFCKRRE-ESGEGYEKAPSYSFKQELSMAAIGITE-HAK---GDSK 877

  Fly   711 RFKYQLLLARKSGKTAFTLYLKSEHERDKW----RKALTEAMESL------EPPGCQSTDHKMEI 765
            :|:    :...|....:|:...||..:..|    ||.||..:|:.      ||....|.....|.
Zfish   878 KFE----IWSSSRDEVYTIQAASEEVKTIWVTEIRKLLTGQLEACKERIFEEPKNEASQQRAPEQ 938

  Fly   766 YTFDAPTTCR 775
            :|.::.:|.|
Zfish   939 FTSESSSTNR 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	10/41 (24%)
		RhoGEF	428..603	CDD:279015	43/189 (23%)
		PH_Vav	624..753	CDD:269930	34/154 (22%)
		PH	641..749	CDD:278594	27/127 (21%)
		C1_1	761..804	CDD:278556	4/15 (27%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
mcf2lb	XP_009303050.1	SEC14	50..193	CDD:214706
		SPEC	328..>473	CDD:321951	27/154 (18%)
		RhoGEF	599..776	CDD:238091	44/207 (21%)
		PH-like	783..914	CDD:327399	34/153 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910