Protein Alignment Vav and mcf2lb

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_068079741.1
• Gene: mcf2lb / 569231
• ZFINID: ZDB-GENE-081104-416
• Length: 1104
• Species: Danio rerio
• Alignment Length: 790
• Identity: 171/790 - (21%)
• Similarity: 285/790 - (36%)
• Gaps: 239/790 - (30%)

  Fly   106 RDAD-LFEPTMLYDLTNFHRVLITL---------------SKLSQCRKV-------QQLHPDL-- 145
            ||.| ...|..|.:|...||:|..|               :||..|.||       |||..:|
Zfish   278 RDPDSSLNPDQLENLATVHRLLSQLNESSTAFDEFWIQHQNKLELCLKVCQFEHNFQQLRTELDR 342

  Fly   146 ----------IGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGS 200
                      :|    :||.:..|    :.::|  |:...:....:|...|..||.......|..
Zfish   343 ATETLNAFSAVG----ISPAQTEH----LLQEL--TNHEKKVCEVLDRVRSLVAEGQGLIDSSQI 397

  Fly   201 LDEN-----SDI--TIENGTEDIDD--------------------YIEDSLSNMCDSTIDNDAED 238
            ||::     |::  ..||.|:::.|                    :.:|.:..:....:|.....
Zfish   398 LDDSIAAKCSELEKASENLTQELKDKQTKLTQAMDLHKRLDMMCKWCDDGIYMLASQPLDKCQSQ 462

  Fly   239 AGVETPLLS-DCQGSHVRELSFDLALDVVSSTTDGASN-----AVTPTPESYA---------RQS 288
            .|.|:.|.. :|......|.. ...:..|....|...|     .||...|..|         |.|
Zfish   463 EGAESALSELECYLETANEKQ-KWEISTVWQEYDNILNNELREQVTRAFEKKASLQEMFDRRRVS 526

  Fly   289 QSPLAA--AAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEY 351
            ...|||  ..|..||  ||.|            .||                   ||.|..:||.
Zfish   527 LKKLAAKQTRPVQPV--APSP------------ESL-------------------SSPAHRDHES 558

  Fly   352 AYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQT 416
            ..| |||.:.          :...| ::.:|.:..:..   :.:..|||  :.|..|.|
Zfish   559 ICI-SEDSDS----------RGSCK-QINSDQVDRSSR---NASVSEEE--ETLAVLRR------ 600

  Fly   417 ASSTSFEQRDYVIRELIDTESNYLDVLTALKTKF--------MGPLERHLNQDELRLIFPRIREL 473
                      :|:.||::||..|::.|..:...:        |.||.....|::..::|..::|:
Zfish   601 ----------HVMNELLETERAYVEELMCVLQGYAAEMDNPSMAPLIPAALQNKKDVLFGNMQEI 655

  Fly   474 VDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFC-------SLLLGAIDYLADVCKKN 531
            .:.|.:...:..|:.|...:: :.:.|||:.....||.::|       ||.....|     |
Zfish   656 YNFHKRIFLRELETYTDYPEL-VGRCFLDWMGELQIYEKYCHNKPRSESLWRQCSD-----C--- 711

  Fly   532 QIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMID 596
                ...|:|::... .||.|...|..|:|||.||.||:.:::|.:....... .|:.|..:::.
Zfish   712 ----AFFQECQKKLE-HKLGLDSYLLKPVQRITKYQLLIKEMIKYSKGCEGSV-ELQAALSSILG 770

  Fly   597 VSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGEL---------HIKAH 652
            :.:.:|    ||.||:.|..           .:||..||   ||||:.|..         |:|..
Zfish   771 ILKAVN----DSMHLIAITG-----------YDGNLGDL---GRLLMQGSFSVWAEHKRGHVKVM 817

  Fly   653 EDQKTK--LRYAFVFDKILIMVKALHIKTGD-----MQYTYRDSHNLADYRVEQSHSRRTIGRDT 710
            |..:.|  .|:.|:.:|.|:..|... ::|:     ..|:::...::|...:.: |::   |...
Zfish   818 ELARFKPMQRHLFLHEKALLFCKRRE-ESGEGYEKAPSYSFKQELSMAAIGITE-HAK---GDSK 877

  Fly   711 RFKYQLLLARKSGKTAFTLYLKSEHERDKW----RKALTEAMESL------EPPGCQSTDHKMEI 765
            :|:    :...|....:|:...||..:..|    ||.||..:|:.      ||....|.....|.
Zfish   878 KFE----IWSSSRDEVYTIQAASEEVKTIWVTEIRKLLTGQLEACKERIFEEPKNEASQQRAPEQ 938

  Fly   766 YTFDAPTTCR 775
            :|.::.:|.|
Zfish   939 FTSESSSTNR 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	12/44 (27%)
		RhoGEF	428..602	CDD:459876	43/188 (23%)
		PH_Vav	624..753	CDD:269930	34/154 (22%)
		C1_VAV	759..810	CDD:410360	4/17 (24%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055
mcf2lb	XP_068079741.1	CRAL_TRIO_2	66..197	CDD:463965
		SPEC	328..>473	CDD:413338	27/154 (18%)
		RhoGEF	599..776	CDD:238091	44/207 (21%)
		PH-like	783..914	CDD:473070	34/153 (22%)