DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and rasgrf1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009291904.1	Gene:	rasgrf1 / 568885	ZFINID:	ZDB-GENE-090311-28	Length:	1263	Species:	Danio rerio

Alignment Length:	429	Identity:	95/429 - (22%)
Similarity:	185/429 - (43%)	Gaps:	74/429 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 SFEQRDYVIRELIDTESNYLDVLTALKTKFMGPL-------ERHLNQDELRLIFPRIRELVDIHT 478
            |..:|:.|:..:::.|:.|:..|..|...|:.||       :..:..|::..||.....::.:|.
Zfish   237 SMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQ 301

  Fly   479 KFLDKLRESLTPNAKVKMAQVFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCE 542
            .|...|:..:.....:.:|.:| |...|.| ||.||......::..||. ||:|:..|:|:::.|
Zfish   302 IFYQGLKARIASWPTLVLADLF-DILLPMLNIYQEFVRNHQYSLQILAH-CKQNRDFDKLLKQYE 364

  Fly   543 RDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRD 607
            ...:..:..|...|:.||.:|.:|.|.|.:|:..|...|.:..||:.||..:.::|:.:::...:
Zfish   365 AKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSE 429

  Fly   608 SDHL---VIIQKVKDSICDIHL------LQNGNGSDLLQY----------GRLLLDGELHIKAHE 653
            ::::   :.|:::....|:|.|      ::.|:   |:|.          |||   |.|.:|
Zfish   430 TENIRKNLAIERMIVEGCEILLDTSQTFVRQGS---LIQVPMSEKGKITRGRL---GSLSLK--- 485

  Fly   654 DQKTKLRYAFVFDKILIMVK-----ALHIKTGDMQYTYRDSHNLADYRV--------EQSHSRRT 705
              |...|..|:|.|.||:..     .||:.............:|.|..:        ::|.|.::
Zfish   486 --KEGERQCFLFSKHLIICTRGSGGKLHLTKVKPHTVQNGVVSLIDCTLIEEPEGTDDESKSEKS 548

  Fly   706 IGRD-TRFKYQLLLARKSGKT-AFTLYLKSEHERDKWRKALTEAMESLEPPGCQ----STDHKM- 763
             |:| ....:::::..|..:: .|.|...|..|:..|...:::.::::...|..    ..:.|:
Zfish   549 -GQDMEHLDFKIVVEPKDSQSFTFILVASSRQEKSAWTSDISQCIDNIRCNGLMMNAFEENSKVT 612

  Fly   764 --EIYTFDAPTTCR----HCSKFLKGRIHQGYRCKVCQI 796
              ::...||...|.    ..||.:..       |||.||
Zfish   613 VPQMIKSDASLYCDDVDIRFSKMMNS-------CKVLQI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	47/182 (26%)
		PH_Vav	624..753	CDD:269930	32/159 (20%)
		PH	641..749	CDD:278594	25/122 (20%)
		C1_1	761..804	CDD:278556	11/43 (26%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
rasgrf1	XP_009291904.1	PH_RasGRF1_2	19..154	CDD:270081
		PH	24..129	CDD:278594
		RhoGEF	244..425	CDD:214619	47/182 (26%)
		PH-like	474..596	CDD:302622	27/130 (21%)
		PH	489..592	CDD:278594	20/103 (19%)
		RasGEF_N	643..>691	CDD:279012	2/2 (100%)
		REM	<928..997	CDD:295342
		RasGEF	1024..1261	CDD:214539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910