DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and spata13

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_005162798.1	Gene:	spata13 / 568426	ZFINID:	ZDB-GENE-091116-25	Length:	1251	Species:	Danio rerio

Alignment Length:	932	Identity:	187/932 - (20%)
Similarity:	321/932 - (34%)	Gaps:	229/932 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CKVIPPDHKAAQPDAEIRILAMTLRDGV--------LLCNLV--------IHLDPSSLDPREFNR 79
            |:.||..|.|....|   :....|.|.:        |:.:.|        :|:..|:..|.::..
Zfish   387 CQTIPILHPAPSCPA---VFISDLDDSLEPPSKTTALISDYVQMAVSSSELHIGDSACPPEKYCE 448

  Fly    80 KPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPD 144
            ..:                ||.| |:.|               |...|.....|.|     |.|.
Zfish   449 PME----------------CHQN-GLND---------------HYSQIPQQCSSPC-----LKPT 476

  Fly   145 LIG--FNLQLSPTERSHSDEAIYKD--------LHSTDLNMRKTSSIDASASSSAEYYDRTSQSG 199
            :.|  .|||...||...:|:.....        |.|.:.:....|.|..|..|.:.....|:.:.
Zfish   477 VNGNDVNLQCLWTEERETDDLEASSDNRITRAFLKSDEASTPAASPITNSCCSESPLGTPTTPNS 541

  Fly   200 SLDENSDITI--------ENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHV-- 254
            ....::..|.        .:....:.||.:.:.|..|....|.:.|:....:.......||::
Zfish   542 PAFVSASPTSVVPRKRAGRSKPRPVSDYGQLASSKFCILEEDRELENMDYTSQKDYISNGSYIES 606

  Fly   255 -----------------RELSFDLALDVVSS-------TTDGASNAV--TPTPESYARQSQSPLA 293
                             |.:|....:|:.||       .|:...:.|  .|.|.......::..|
Zfish   607 SRPENGHVCTQKESRKRRPISVIGGVDLYSSQPAEQKDDTESLPSPVCRPPVPSHRVPPYRAVSA 671

  Fly   294 AAAPSVPVSAAP------GPPMGRLVSTSSSSSSLL---VSE----------------------- 326
            ...|.|...:.|      |...||.|.:..||..:|   |||
Zfish   672 RLRPCVFSQSTPIGLDRMGRRKGRRVLSDGSSDPMLEDSVSEEDGSFEELTEGTPYLQPEVDLFT 736

  Fly   327 -SQRLQ--RA--AAAVYNYRSSMASTEHEYAY----------IYSED-------DEKVYEDLCYV 369
             :|.::  ||  |.|::::   :...|.|.|:          :..:|       |.:.:....:|
Zfish   737 LNQHIESGRAVYAEALWDH---VTMEEQELAFKAGEVIRVLDVQEQDWWWGMVGDREAWFPSSFV 798

  Fly   370 TFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELID 434
            ..:.. :.:.:::::       :.|...||.:..|....:...|.|        .|..|::|::|
Zfish   799 RVRVN-QEDSSSESV-------ESTPDTEEPIPSDSHKQNPEHRKQ--------MRANVVKEIMD 847

  Fly   435 TESNYLDVLTALKTKFMGPLERH---LNQDELRLIFPRIRELVDIHTKFLDKLRESLTP-NAKV- 494
            ||..|:..|..:...::....:|   ....:|:.||..|.::.....|||..|.....| |..:
Zfish   848 TERVYIKHLKDICEGYIRQCRKHPGMFTDTQLKTIFSNIEDIYRFQRKFLKDLERKYNPENPHLS 912

  Fly   495 KMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVP 559
            ::...||...|.|.||.|:|:....|...|..:.|::: .....:.|.....:..:.:...|..|
Zfish   913 EIGSCFLQQEEGFSIYSEYCNTHPVACAELQRLMKQSR-YKHFFEACRLLQQMIDISIAGFLLTP 976

  Fly   560 MQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDI 624
            :|:|.||.|.|.:|:|.|...|.|:..:..|.:||.:|:..|||.||..:.:..|...:.:|  :
Zfish   977 VQKICKYPLQLGELLKYTPKEHSDFAGVCAAHKAMKNVASLINERKRRLESIDTIAHWQVAI--L 1039

  Fly   625 HLLQNGNGSDLL-QYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK-------ALHIKTGD 681
            |..    |.|:| :...|:..||| .:.....||:.|..|:||..|:..|       .||.: |.
Zfish  1040 HWA----GEDVLARSSELIHSGEL-TRIVRPGKTQQRSYFLFDHQLVFCKKDVLRRDLLHYR-GR 1098

  Fly   682 MQYTYRDSHNLADYRVEQSHSRRTIGRDTR---FKYQLLLARKSGKTAF-TLYLKSEHERDKWRK 742
            |.....:..:|.|            ||.|.   .|...||......... .|..|...::.:|.:
Zfish  1099 MDTDLLEPSDLPD------------GRHTELGLLKNAFLLRHAENLNVLCVLCCKKSQDKQRWLQ 1151

  Fly   743 ALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRI----HQGYRCKVCQISVHKGCI 803
            |.....:.::    :..:..|||..........:..|...|::    :.|:........:|.
Zfish  1152 AFARERKRVQ----EDQEMGMEITEAQRKQAVHNARKSKHGKMKNMNYSGHPAPPHHQPLHP--- 1209

  Fly   804 SSTGRCKQNPVSVPPPVCDRQL 825
                 ..|..|:||..|..:|:
Zfish  1210 -----LHQRHVTVPTSVPQQQV 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	20/116 (17%)
		RhoGEF	428..603	CDD:279015	48/179 (27%)
		PH_Vav	624..753	CDD:269930	32/140 (23%)
		PH	641..749	CDD:278594	28/118 (24%)
		C1_1	761..804	CDD:278556	7/46 (15%)
		SH2_Vav_family	824..934	CDD:198193	1/2 (50%)
		SH3	940..993	CDD:302595
spata13	XP_005162798.1	SH3	747..800	CDD:327375	8/55 (15%)
		RhoGEF	841..1020	CDD:214619	48/179 (27%)
		PH_Collybistin_ASEF	1025..1163	CDD:269931	34/161 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940