DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and farp2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009300696.1	Gene:	farp2 / 567490	ZFINID:	ZDB-GENE-030131-2993	Length:	1051	Species:	Danio rerio

Alignment Length:	980	Identity:	194/980 - (19%)
Similarity:	326/980 - (33%)	Gaps:	321/980 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KVIPPDHKAAQPDAEIRILAMTLR----DGVLLCN------LVIHL------DPSSLDPREFNRK 80
            |..|||....|.:....:.::.::    ||.|.|.      |..||      |...|..|||.:.
Zfish   129 KFFPPDPGQLQEEFTRYLFSLQIKRDLLDGRLSCTENTAALLASHLVQSEIGDYDDLADREFLKM 193

  Fly    81 PQMAQFLCSKNIKLFLDVCHNN----------------------FGIRDADLFEPT--------- 114
            .::..  |.::::..:...|..                      ||:|    |.|.
Zfish   194 NKLLP--CQEHVQEKIMELHRRHTGQTPAESDFQVLEIARKLEMFGVR----FHPAADREGTKIN 252

  Fly   115 -----MLYDLTNFHRVLIT-----LSKLSQCRK--VQQLHPDLIGFNLQLSPTERSHSD------ 161
                 |...:...|..:.|     :.|||..||  :.:|||::.|          .|.|
Zfish   253 LAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPEVHG----------PHQDTLEFLM 307

  Fly   162 ------EAIYKDL---HS----TDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGT 213
                  :..:|:.   ||    .|....|:.:|..|..||..|..||.
Zfish   308 GSRDQCKIFWKNCVEHHSFFRLLDQPQPKSKAIFFSRGSSFRYSGRTQ----------------- 355

  Fly   214 EDIDDYIEDSLSNMCDSTIDNDAEDAGV-ETPLLSDCQGSHVRELSFDLALDVVS---STTDGAS 274
            :.:.:|:.||                |: .||.  ..:.|.:|..:..||.||..   |..|...
Zfish   356 KQLVEYVRDS----------------GLRRTPY--QRRNSKIRMSTRSLASDVPKQNLSFNDSLR 402

  Fly   275 NAVTPTPESYARQSQSPLAAAAPSVPVSA------------------APGPPMGRLVSTSSSSSS 321
            ..:.|:..:.:.||     ..||||.:.|                  ||.|.....:.|:|.|:
Zfish   403 THIPPSSITASFQS-----LHAPSVSMRAETPNQLLHLHQTQHQPLRAPSPMKQDPIKTNSQST- 461

  Fly   322 LLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIAC 386
                            |.:..|:|....:.:....:....:.......|.....:......:...
Zfish   462 ----------------YAFPDSIAIDSPQLSPFNDKGPLCLSPSFQMSTLSLPGQAPSPLQSPIL 510

  Fly   387 NGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFM 451
            |..|....:..||         .|..|..|      ::..::.:|::.||..||..|..:...|.
Zfish   511 NEVGTARLDEDEE---------GRRKRYPT------DKAYFIAKEILTTERTYLKDLEVITVWFR 560

  Fly   452 GPL--ERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLT-----PNAKVK-----MAQVFLDFR 504
            ..:  |..:.:..:.|:|..|..:.:.|..||.::.:.|.     .||.||     :..|.|
Zfish   561 SAVIKENAMPEGLMTLLFSNIDPIYEFHRGFLKEIDQRLALWEGRSNAHVKGDYQRIGDVML--- 622

  Fly   505 EPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL------VQKCERDYNVGKLQ------LRDILS 557
                  ...|||.    ::...:.|.::::.:|      |:|.|..|...:||      |...|.
Zfish   623 ------RNMCSLK----EFTGYLQKHDEVLTELEKATKRVKKLETVYKEFELQKVCYLPLNTFLL 677

  Fly   558 VPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSIC 622
            .|:||::.|.|:|::|.|..||.|.||   :..|||:.:|::...:::.....|...||:.:...
Zfish   678 KPIQRLMHYKLILERLCKHYSPQHRDY---DDCKEALKEVAEIATQLQSSLIRLENFQKLTELQR 739

  Fly   623 DIHLLQN--GNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVF-DKILIMVKALHIKTGDMQY 684
            |:..::|  ..|.:.::.|.|.   :|..|..:.     |..|:| |.:|...|.:   |...|:
Zfish   740 DLIGIENLTAPGREFIREGCLY---KLTKKGLQQ-----RMFFLFSDMLLYTSKGV---TATNQF 793

  Fly   685 TYRDS---HNL----ADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLY---------LKS 733
            .....   |.:    .|..||:|.:..::..                 .||:|         ..|
Zfish   794 KVHGQLPLHGMILIVLDAPVEESENEWSVPH-----------------CFTIYSAQRTIVVAASS 841

  Fly   734 EHERDKWRKALTEAMES-----------LEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQ 787
            :.|.:||.:.|..|:|.           |:|..|..::...:..:.:..:.....|.
Zfish   842 KVEMNKWIEDLNMAIEMSKKCQEKSDVLLDPSLCDRSNRSSDEVSLEQESEDDMNSS-------- 898

  Fly   788 GYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRL--ENRRIG 850
              ||.:.:.|.|:             .:....||        |.. |.....:.|.|  ||:..|
Zfish   899 --RCSLDKQSHHR-------------ANTTMHVC--------WHR-NTSVSMSDHSLAVENQLSG 939

  Fly   851 TYLLR 855
             ||||
Zfish   940 -YLLR 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	27/156 (17%)
		RhoGEF	428..603	CDD:279015	51/198 (26%)
		PH_Vav	624..753	CDD:269930	30/158 (19%)
		PH	641..749	CDD:278594	25/124 (20%)
		C1_1	761..804	CDD:278556	5/42 (12%)
		SH2_Vav_family	824..934	CDD:198193	11/34 (32%)
		SH3	940..993	CDD:302595
farp2	XP_009300696.1	B41	53..241	CDD:214604	22/117 (19%)
		FERM_N	55..118	CDD:286467
		FERM_M	138..241	CDD:278785	18/108 (17%)
		FERM_C_FARP1-like	228..348	CDD:270014	27/133 (20%)
		FA	341..382	CDD:285894	14/75 (19%)
		RhoGEF	537..720	CDD:279015	51/198 (26%)
		PH1_FARP1-like	747..861	CDD:269928	28/141 (20%)
		PH	755..857	CDD:278594	26/129 (20%)
		PH2_FARP1-like	933..1030	CDD:270055	7/12 (58%)
		PH	938..1031	CDD:278594	5/7 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910