DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and itsn2a

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021324162.1	Gene:	itsn2a / 566412	ZFINID:	ZDB-GENE-041014-84	Length:	1666	Species:	Danio rerio

Alignment Length:	872	Identity:	186/872 - (21%)
Similarity:	295/872 - (33%)	Gaps:	266/872 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETP------- 244
            ||.|..: .|.||.|||...:......|..|              :...|||..:.|.
Zfish   945 SSVEEIE-VSDSGLLDEYVALYTYESPESGD--------------LTFSAEDVVLVTEKEGEWWR 994

  Fly   245 -LLSDCQG----SHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAA 304
             .:.|..|    ::|:....|.|...|.|.....:...|.:|.:...|             :|..
Zfish   995 GCIGDQTGLFPSNYVKPKEPDTASSAVPSKKPEIAQVTTVSPATTPEQ-------------LSLT 1046

  Fly   305 PGPP------------MGRLVST---------SSSSSSLLVSESQRLQRA------AAAVYNYRS 342
            ||..            :|.|.:.         .||:..||.:.|.::..|      ..|:|:|::
Zfish  1047 PGQLIVVLHKNSNSWWLGELQARGKKRKKGWFQSSNVRLLEANSGKITPAPQPLCQVIAMYDYKA 1111

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTN----TKEEEVYQ 403
                         :..||..::....:|...|..|:.....:| ..||...||    |.|.:..|
Zfish  1112 -------------ANKDEMSFQKGQLITVLNKDNPDWWKGEVA-GVTGLFPTNYVKMTTECDPSQ 1162

  Fly   404 DLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLER--HLNQDELRLI 466
            ..||   ...|..:..|...:|...|.|||.||.:||:.|......|..|:..  .|.:.|:.:|
Zfish  1163 QWCA---DLLSLDSMCTEERKRQGYIHELIQTEESYLEDLELAVEVFYKPMAESGRLTEAEISMI 1224

  Fly   467 FPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFL----IYGEFCSLLLGAIDYLADV 527
            |...|||:...||.|..||.......:....||..|.....|    .|..|||..|.|...|...
Zfish  1225 FVNWRELIMCSTKLLKALRVRKKTAGERMPVQVVGDILSSELSHMQAYIRFCSCQLNAAALLQQK 1289

  Fly   528 CKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKE 592
            ..|:......::|...:|....:.|...|..|||||.:|.||:..:::.|.|.|.|:.:|:.|.|
Zfish  1290 TDKSLDFKLFLKKIASNYRCKGMPLSSFLLKPMQRITRYPLLIKNILENTPPAHADHSNLQAALE 1354

  Fly   593 AMIDVSQYINEV---KRDSDHLVIIQKVKDSICD---IHLLQNGNGSDLLQYGRLLLDGELHIKA 651
            ...::...:||.   |.:||.|..||  ...:||   .||:.| :.::.|...:||..|:|
Zfish  1355 QAEELCSQVNEAVREKENSDRLEWIQ--NHVLCDGVIEHLVFN-SLTNCLGPRKLLHSGKL---- 1412

  Fly   652 HEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVE-QSHSRRTIGRDTRFKYQ 715
            |:.:.:|..:|.:|:..|::.           ||.:...:..|.... .|:::..:.:...|..:
Zfish  1413 HKTKSSKELWALLFNDFLLLT-----------YTSKQFSSSPDKLFNPNSNTQYKMYKTPVFLNE 1466

  Fly   716 LLLARKSGKTA-------------FTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYT 767
            :|:...|..::             :||...:.:||..|.:.:..|           :||.:|
Zfish  1467 VLVKMPSDPSSDDPVFHISHIDRVYTLKTDTINERTTWVQKIKAA-----------SDHFIE--- 1517

  Fly   768 FDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFA 832
                                                  |.:.|
Zfish  1518 --------------------------------------TEKLK---------------------- 1522

  Fly   833 GNMDRETA--AHRLENRRIGTYLLRV---------RPQGPSTAH--ETMYALSLKTDDNVIKHMK 884
                ||.|  |...:|..||..|:.|         :|.|.|..:  .||.|
Zfish  1523 ----REKAYQARSQKNSGIGRLLVTVLEATELKPCKPNGKSNPYCELTMGA-------------- 1569

  Fly   885 INQENSGDSMLYCLSSRRHFKTIVELVSY---YERNDLGENFAGLNQSLQWPYKEVIATALYDYE 946
                       .|.:||....|:....|:   :...||              |::|:...:::.:
Zfish  1570 -----------QCYTSRHQPDTLNPKWSFNCQFFIKDL--------------YQDVLCLTVFERD 1609

  Fly   947 PKAGSNQLQLRTDCQVLVIGKDGDSKG 973
            ..:..:.|. ||:..|..|.||.|.||
Zfish  1610 QFSPDDFLG-RTEVPVATIKKDQDGKG 1635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	54/180 (30%)
		PH_Vav	624..753	CDD:269930	26/142 (18%)
		PH	641..749	CDD:278594	22/121 (18%)
		C1_1	761..804	CDD:278556	2/42 (5%)
		SH2_Vav_family	824..934	CDD:198193	22/125 (18%)
		SH3	940..993	CDD:302595	10/34 (29%)
itsn2a	XP_021324162.1	EH	7..92	CDD:197477
		EH	214..293	CDD:197477
		SMC_N	453..>727	CDD:330553
		SH3_Intersectin2_1	776..832	CDD:212921
		SH3	881..932	CDD:327375
		SH3_Intersectin_3	960..1011	CDD:212772	10/64 (16%)
		SH3_Intersectin2_4	1028..1086	CDD:212927	10/70 (14%)
		SH3	1101..1154	CDD:327375	13/66 (20%)
		RhoGEF	1181..1364	CDD:238091	55/182 (30%)
		PH_13	1383..1523	CDD:318790	33/233 (14%)
		C2_Intersectin	1524..1658	CDD:176021	33/152 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910