DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and itsn2a

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_021324162.1 Gene:itsn2a / 566412 ZFINID:ZDB-GENE-041014-84 Length:1666 Species:Danio rerio


Alignment Length:872 Identity:186/872 - (21%)
Similarity:295/872 - (33%) Gaps:266/872 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 SSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETP------- 244
            ||.|..: .|.||.|||...:......|..|              :...|||..:.|.       
Zfish   945 SSVEEIE-VSDSGLLDEYVALYTYESPESGD--------------LTFSAEDVVLVTEKEGEWWR 994

  Fly   245 -LLSDCQG----SHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAA 304
             .:.|..|    ::|:....|.|...|.|.....:...|.:|.:...|             :|..
Zfish   995 GCIGDQTGLFPSNYVKPKEPDTASSAVPSKKPEIAQVTTVSPATTPEQ-------------LSLT 1046

  Fly   305 PGPP------------MGRLVST---------SSSSSSLLVSESQRLQRA------AAAVYNYRS 342
            ||..            :|.|.:.         .||:..||.:.|.::..|      ..|:|:|::
Zfish  1047 PGQLIVVLHKNSNSWWLGELQARGKKRKKGWFQSSNVRLLEANSGKITPAPQPLCQVIAMYDYKA 1111

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTN----TKEEEVYQ 403
                         :..||..::....:|...|..|:.....:| ..||...||    |.|.:..|
Zfish  1112 -------------ANKDEMSFQKGQLITVLNKDNPDWWKGEVA-GVTGLFPTNYVKMTTECDPSQ 1162

  Fly   404 DLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLER--HLNQDELRLI 466
            ..||   ...|..:..|...:|...|.|||.||.:||:.|......|..|:..  .|.:.|:.:|
Zfish  1163 QWCA---DLLSLDSMCTEERKRQGYIHELIQTEESYLEDLELAVEVFYKPMAESGRLTEAEISMI 1224

  Fly   467 FPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFL----IYGEFCSLLLGAIDYLADV 527
            |...|||:...||.|..||.......:....||..|.....|    .|..|||..|.|...|...
Zfish  1225 FVNWRELIMCSTKLLKALRVRKKTAGERMPVQVVGDILSSELSHMQAYIRFCSCQLNAAALLQQK 1289

  Fly   528 CKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKE 592
            ..|:......::|...:|....:.|...|..|||||.:|.||:..:::.|.|.|.|:.:|:.|.|
Zfish  1290 TDKSLDFKLFLKKIASNYRCKGMPLSSFLLKPMQRITRYPLLIKNILENTPPAHADHSNLQAALE 1354

  Fly   593 AMIDVSQYINEV---KRDSDHLVIIQKVKDSICD---IHLLQNGNGSDLLQYGRLLLDGELHIKA 651
            ...::...:||.   |.:||.|..||  ...:||   .||:.| :.::.|...:||..|:|    
Zfish  1355 QAEELCSQVNEAVREKENSDRLEWIQ--NHVLCDGVIEHLVFN-SLTNCLGPRKLLHSGKL---- 1412

  Fly   652 HEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVE-QSHSRRTIGRDTRFKYQ 715
            |:.:.:|..:|.:|:..|::.           ||.:...:..|.... .|:::..:.:...|..:
Zfish  1413 HKTKSSKELWALLFNDFLLLT-----------YTSKQFSSSPDKLFNPNSNTQYKMYKTPVFLNE 1466

  Fly   716 LLLARKSGKTA-------------FTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYT 767
            :|:...|..::             :||...:.:||..|.:.:..|           :||.:|   
Zfish  1467 VLVKMPSDPSSDDPVFHISHIDRVYTLKTDTINERTTWVQKIKAA-----------SDHFIE--- 1517

  Fly   768 FDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFA 832
                                                  |.:.|                      
Zfish  1518 --------------------------------------TEKLK---------------------- 1522

  Fly   833 GNMDRETA--AHRLENRRIGTYLLRV---------RPQGPSTAH--ETMYALSLKTDDNVIKHMK 884
                ||.|  |...:|..||..|:.|         :|.|.|..:  .||.|              
Zfish  1523 ----REKAYQARSQKNSGIGRLLVTVLEATELKPCKPNGKSNPYCELTMGA-------------- 1569

  Fly   885 INQENSGDSMLYCLSSRRHFKTIVELVSY---YERNDLGENFAGLNQSLQWPYKEVIATALYDYE 946
                       .|.:||....|:....|:   :...||              |::|:...:::.:
Zfish  1570 -----------QCYTSRHQPDTLNPKWSFNCQFFIKDL--------------YQDVLCLTVFERD 1609

  Fly   947 PKAGSNQLQLRTDCQVLVIGKDGDSKG 973
            ..:..:.|. ||:..|..|.||.|.||
Zfish  1610 QFSPDDFLG-RTEVPVATIKKDQDGKG 1635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 54/180 (30%)
PH_Vav 624..753 CDD:269930 26/142 (18%)
PH 641..749 CDD:278594 22/121 (18%)
C1_1 761..804 CDD:278556 2/42 (5%)
SH2_Vav_family 824..934 CDD:198193 22/125 (18%)
SH3 940..993 CDD:302595 10/34 (29%)
itsn2aXP_021324162.1 EH 7..92 CDD:197477
EH 214..293 CDD:197477
SMC_N 453..>727 CDD:330553
SH3_Intersectin2_1 776..832 CDD:212921
SH3 881..932 CDD:327375
SH3_Intersectin_3 960..1011 CDD:212772 10/64 (16%)
SH3_Intersectin2_4 1028..1086 CDD:212927 10/70 (14%)
SH3 1101..1154 CDD:327375 13/66 (20%)
RhoGEF 1181..1364 CDD:238091 55/182 (30%)
PH_13 1383..1523 CDD:318790 33/233 (14%)
C2_Intersectin 1524..1658 CDD:176021 33/152 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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